ZFYVE16

Last updated
ZFYVE16
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ZFYVE16 , PPP1R69, zinc finger FYVE-type containing 16
External IDs OMIM: 608880; MGI: 2145181; HomoloGene: 8826; GeneCards: ZFYVE16; OMA:ZFYVE16 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001105251
NM_001284236
NM_001284237
NM_014733
NM_001349434

Contents

NM_173392

RefSeq (protein)

NP_001098721
NP_001271165
NP_001271166
NP_055548
NP_001336363

NP_775568

Location (UCSC) Chr 5: 80.41 – 80.48 Mb Chr 13: 92.62 – 92.67 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Zinc finger FYVE domain-containing protein 16 is a protein that in humans is encoded by the ZFYVE16 gene. [5] [6]

The ZFYVE16 gene encodes endofin, an endosomal protein implicated in regulating membrane trafficking. It is characterized by the presence of a phosphatidylinositol 3-phosphate-binding FYVE domain positioned in the middle of the molecule. [7]

In melanocytic cells ZFYVE16 gene expression may be regulated by MITF. [8]

Interactions

ZFYVE16 has been shown to interact with TOM1. [7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000039319 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021706 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Seet LF, Hong W (November 2001). "Endofin, an endosomal FYVE domain protein". The Journal of Biological Chemistry. 276 (45): 42445–54. doi: 10.1074/jbc.M105917200 . PMID   11546807.
  6. "Entrez Gene: ZFYVE16 zinc finger, FYVE domain containing 16".
  7. 1 2 Seet LF, Liu N, Hanson BJ, Hong W (February 2004). "Endofin recruits TOM1 to endosomes". The Journal of Biological Chemistry. 279 (6): 4670–9. doi: 10.1074/jbc.M311228200 . PMID   14613930.
  8. Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, et al. (December 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research. 21 (6): 665–76. doi: 10.1111/j.1755-148X.2008.00505.x . PMID   19067971. S2CID   24698373.

Further reading