ZFYVE16

ZFYVE16
Identifiers
Aliases	ZFYVE16 , PPP1R69, zinc finger FYVE-type containing 16
External IDs	OMIM: 608880; MGI: 2145181; GeneCards: ZFYVE16
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3T7L
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q14.1 Start 80,408,013 bp [1] End 80,483,379 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13|13 C3 Start 92,623,616 bp [2] End 92,667,376 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum endothelial cell inferior ganglion of vagus nerve subthalamic nucleus pars reticulata inferior olivary nucleus superior vestibular nucleus C1 segment tibia external globus pallidus Top expressed in spermatocyte genital tubercle tail of embryo spermatid granulocyte choroid plexus of fourth ventricle ventricular zone cumulus cell urethra right kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function 1-phosphatidylinositol binding protein binding phosphatidylinositol-3,4,5-trisphosphate binding metal ion binding Cellular component endosome early endosome early endosome membrane intracellular membrane-bounded organelle membrane cytoplasm cytosol Biological process regulation of endocytosis endosomal transport protein targeting to lysosome BMP signaling pathway signal transduction vesicle organization Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 9765 218441 Ensembl ENSG00000039319 ENSMUSG00000021706 UniProt Q7Z3T8 Q80U44 RefSeq (mRNA) NM_001105251 NM_001284236 NM_001284237 NM_014733 NM_001349434 NM_173392 RefSeq (protein) NP_001098721 NP_001271165 NP_001271166 NP_055548 NP_001336363 NP_775568 Location (UCSC) Chr 5: 80.41 – 80.48 Mb Chr 13: 92.62 – 92.67 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Zinc finger FYVE domain-containing protein 16 is a protein that in humans is encoded by the ZFYVE16 gene. ^{[5] [6]}

The ZFYVE16 gene encodes endofin, an endosomal protein implicated in regulating membrane trafficking. It is characterized by the presence of a phosphatidylinositol 3-phosphate-binding FYVE domain positioned in the middle of the molecule. ^[7]

In melanocytic cells ZFYVE16 gene expression may be regulated by MITF. ^[8]

Interactions

ZFYVE16 has been shown to interact with TOM1. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000039319 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021706 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Seet LF, Hong W (November 2001). "Endofin, an endosomal FYVE domain protein". The Journal of Biological Chemistry. 276 (45): 42445–54. doi: 10.1074/jbc.M105917200 . PMID   11546807.
6. "Entrez Gene: ZFYVE16 zinc finger, FYVE domain containing 16".
7. Seet LF, Liu N, Hanson BJ, Hong W (February 2004). "Endofin recruits TOM1 to endosomes". The Journal of Biological Chemistry. 279 (6): 4670–9. doi: 10.1074/jbc.M311228200 . PMID   14613930.
8. Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, et al. (December 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research. 21 (6): 665–76. doi: 10.1111/j.1755-148X.2008.00505.x . PMID   19067971. S2CID   24698373.

Further reading

• Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, et al. (April 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 4 (2): 141–50. doi: 10.1093/dnares/4.2.141 . PMID   9205841.
• Seet LF, Liu N, Hanson BJ, Hong W (February 2004). "Endofin recruits TOM1 to endosomes". The Journal of Biological Chemistry. 279 (6): 4670–9. doi: 10.1074/jbc.M311228200 . PMID   14613930.
• Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (May 2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Analytical Chemistry. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID   15144186.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, et al. (July 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.
• Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, et al. (January 2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology. 23 (1): 94–101. doi:10.1038/nbt1046. PMID   15592455. S2CID   7200157.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Zhao BM, Hoffmann FM (September 2006). "Inhibition of transforming growth factor-beta1-induced signaling and epithelial-to-mesenchymal transition by the Smad-binding peptide aptamer Trx-SARA". Molecular Biology of the Cell. 17 (9): 3819–31. doi:10.1091/mbc.E05-10-0990. PMC   1556379 . PMID   16775010.
• Chen YG, Wang Z, Ma J, Zhang L, Lu Z (March 2007). "Endofin, a FYVE domain protein, interacts with Smad4 and facilitates transforming growth factor-beta signaling". The Journal of Biological Chemistry. 282 (13): 9688–95. doi: 10.1074/jbc.M611704200 . PMID   17272273.
• Chen Y, Low TY, Choong LY, Ray RS, Tan YL, Toy W, et al. (July 2007). "Phosphoproteomics identified Endofin, DCBLD2, and KIAA0582 as novel tyrosine phosphorylation targets of EGF signaling and Iressa in human cancer cells". Proteomics. 7 (14): 2384–97. doi:10.1002/pmic.200600968. PMID   17570516. S2CID   23944956.