ZHX3

ZHX3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DA5, 2DN0
Identifiers
Aliases	ZHX3 , TIX1, zinc fingers and homeoboxes 3
External IDs	OMIM: 609598 MGI: 2444772 HomoloGene: 9000 GeneCards: ZHX3
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20q12 Start 41,178,448 bp [1] End 41,317,672 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 H2 Start 160,590,628 bp [2] End 160,714,918 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve gastric mucosa Achilles tendon corpus callosum stromal cell of endometrium popliteal artery internal globus pallidus nucleus accumbens caudate nucleus renal medulla Top expressed in otolith organ utricle secondary oocyte spermatid seminiferous tubule ascending aorta aortic valve left lobe of liver ciliary body kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding protein binding protein homodimerization activity transcription corepressor activity metal ion binding protein heterodimerization activity nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm Biological process cell differentiation positive regulation of osteoblast differentiation negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23051 320799 Ensembl ENSG00000174306 ENSMUSG00000035877 UniProt Q9H4I2 Q8C0Q2 RefSeq (mRNA) NM_015035 NM_177263 RefSeq (protein) NP_055850 NP_796237 Location (UCSC) Chr 20: 41.18 – 41.32 Mb Chr 2: 160.59 – 160.71 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Zinc fingers and homeoboxes protein 3 is a protein that in humans is encoded by the ZHX3 gene. ^{[5] [6]}

This gene encodes a member of the zinc fingers and homeoboxes (ZHX) gene family. The encoded Protein contains two C2H2-type zinc fingers and five Homeodomains and forms a Dimer with itself or with Zinc fingers and homeoboxes family member 1. In the Nucleus, the dimerized protein interacts with the A subunit of the ubiquitous transcription factor nuclear factor-Y and may function as a transcriptional repressor. ^[6] fx

References

1. GRCh38: Ensembl release 89: ENSG00000174306 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035877 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi: 10.1093/dnares/4.5.307 . PMID   9455477.
6. "Entrez Gene: ZHX3 zinc fingers and homeoboxes 3".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi: 10.1093/dnares/9.3.99 . PMID   12168954.
• Liu G, Clement LC, Kanwar YS, et al. (2007). "ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome". J. Biol. Chem. 281 (51): 39681–92. doi: 10.1074/jbc.M606664200 . PMID   17056598.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569. S2CID   13709685.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Kawata H, Yamada K, Shou Z, et al. (2004). "The mouse zinc-fingers and homeoboxes (ZHX) family; ZHX2 forms a heterodimer with ZHX3". Gene. 323: 133–40. doi:10.1016/j.gene.2003.09.013. PMID   14659886.
• Yamada K, Kawata H, Shou Z, et al. (2003). "Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3". Biochem. J. 373 (Pt 1): 167–78. doi:10.1042/BJ20021866. PMC   1223464 . PMID   12659632.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Jia L, Young MF, Powell J, et al. (2002). "Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis". Genomics. 79 (1): 7–17. doi:10.1006/geno.2001.6683. PMID   11827452.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.