ZIC1

ZIC1
Identifiers
Aliases	ZIC1 , ZIC, ZNF201, CRS6, Zic family member 1, BAIDCS
External IDs	OMIM: 600470; MGI: 106683; HomoloGene: 2562; GeneCards: ZIC1; OMA:ZIC1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	147,510,293 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	91,247,863 bp
RNA expression pattern
	Top expressed in
	paraflocculus of cerebellum; ; optic nerve; ; right hemisphere of cerebellum; ; pons; ; Epithelium of choroid plexus; ; endothelial cell; ; lateral nuclear group of thalamus; ; dorsal motor nucleus of vagus nerve; ; trigeminal ganglion; ; cerebellar vermis;
	Top expressed in
	habenula; ; cerebellar vermis; ; lobe of cerebellum; ; lateral septal nucleus; ; ciliary body; ; lateral geniculate nucleus; ; medial geniculate nucleus; ; iris; ; medial dorsal nucleus; ; pineal gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding ; DNA-binding transcription factor activity ; DNA-binding transcription activator activity, RNA polymerase II-specific ; metal ion binding ; RNA polymerase II cis-regulatory region sequence-specific DNA binding ; nucleic acid binding ; RNA polymerase II transcription regulatory region sequence-specific DNA binding ; DNA-binding transcription factor activity, RNA polymerase II-specific ;
Cellular component	cytoplasm ; nucleus ;
Biological process	pattern specification process ; cell differentiation ; regulation of transcription, DNA-templated ; transcription by RNA polymerase II ; transcription, DNA-templated ; nervous system development ; positive regulation of transcription, DNA-templated ; multicellular organism development ; regulation of smoothened signaling pathway ; central nervous system development ; brain development ; inner ear morphogenesis ; spinal cord development ; positive regulation of protein import into nucleus ; positive regulation of transcription by RNA polymerase II ; adult walking behavior ;
	Sources:Amigo / QuickGO
Orthologs
	7545
	22771
	ENSG00000152977
	ENSMUSG00000032368
	Q15915
	P46684
	NM_003412
	NM_009573 ; NM_001376941
	NP_003403
	NP_033599 ; NP_001363870
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 16, 2024

ZIC1 is a member of the Zinc finger of the cerebellum (ZIC) protein family.^[5]^[6]

ZIC1 is classified as a ZIC protein due to conservation of the five C2H2 zinc fingers, which enables the protein to interact with DNA and proteins. ZIC1 is found in close genomic configuration in another member of this protein family, ZIC4. Correct function of these proteins is critical for early development, and as such mutations of the genes encoding these proteins is known to result in various congenital defects. For example, if function of both ZIC1 and ZIC4 is lost (which can occur via an interstitial deletion due to their adjacent location) then this may result in the Dandy–Walker malformation.^[7]

Interactions

ZIC1 has been shown to interact with GLI1 ^[8] and GLI3.^[8]

Related Research Articles

Zinc finger protein GLI1 also known as glioma-associated oncogene is a protein that in humans is encoded by the GLI1 gene. It was originally isolated from human glioblastoma cells.

Zinc finger protein GLI3 is a protein that in humans is encoded by the GLI3 gene.

T-cell acute lymphocytic leukemia protein 1 is a protein that in humans is encoded by the TAL1 gene.

Zinc finger protein Gfi-1 is a transcriptional repressor that in humans is encoded by the GFI1 gene. It is important normal hematopoiesis. Gfi1 is a transcriptional repressor that plays a critical role in hematopoiesis and in protecting hematopoietic cells against stress-induced apoptosis. Recent research has shown that Gfi1 upregulates the expression of the nuclear protein Hemgn, which contributes to its anti-apoptotic activity. This upregulation is mediated through a specific 16-bp promoter region and is dependent on Gfi1’s interaction with the histone demethylase LSD1.

Krueppel-like factor 10 is a protein that in humans is encoded by the KLF10 gene.

Suppressor of fused homolog is a protein that in humans is encoded by the SUFU gene. In molecular biology, the protein domain suppressor of fused protein (Sufu) has an important role in the cell. The Sufu is important in negatively regulating an important signalling pathway in the cell, the Hedgehog signalling pathway (HH). This particular pathway is crucial in embryonic development. There are several homologues of Sufu, found in a wide variety of organisms.

ZIC3 is a member of the Zinc finger of the cerebellum (ZIC) protein family.

Zinc finger protein 40 is a protein that in humans is encoded by the HIVEP1 gene.

Zinc finger protein basonuclin-1 is a protein that in humans is encoded by the BNC1 gene.

Krueppel-like factor 12 is a protein that in humans is encoded by the KLF12 gene.

Zinc finger protein ZIC2 is a protein that in humans is encoded by the ZIC2 gene. ZIC2 is a member of the Zinc finger of the cerebellum (ZIC) protein family.

Zinc finger protein OZF is a protein that in humans is encoded by the ZNF146 gene.

Zinc finger protein ZFPM2, i.e. zinc finger protein, FOG family member 2, but also termed Friend of GATA2, Friend of GATA-2, FOG2, or FOG-2, is a protein that in humans is encoded by the ZFPM2 and in mice by the Zfpm2 gene.

Zinc fingers and homeoboxes protein 3 is a protein that in humans is encoded by the ZHX3 gene.

Zinc finger protein 143 is a protein that in humans is encoded by the ZNF143 gene.

Protein Jade-3 is a protein that in humans is encoded by the PHF16 gene.

Zinc finger protein 267 is a protein that in humans is encoded by the ZNF267 gene.

Zinc fingers and homeoboxes protein 2 is a protein that in humans is encoded by the ZHX2 gene.

Zinc finger protein 57 homolog (ZFP57), also known as zinc finger protein 698 (ZNF698), is a protein that in humans is encoded by the ZFP57 gene.

ZIC5 is a member of the Zinc finger of the cerebellum (ZIC) protein family. ZIC5 is located on chromosome 13 in a divergently transcribed gene pair with the closely related gene ZIC2. It has been suggested that this tandem arrangement allows ZIC2 and ZIC5 to share regulatory elements and causes the two genes to have very similar expression patterns.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000152977 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032368 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ali RG, Bellchambers HM, Arkell RM (November 2012). "Zinc finger of the cerebellum (Zic): Transcription factors and co-factors". Int J Biochem Cell Biol. 44 (11): 2065–8. doi:10.1016/j.biocel.2012.08.012. PMID 22964024.
↑ "Entrez Gene: ZIC1 Zic family member 1 (odd-paired homolog, Drosophila)".
↑ Grinberg I, Northrup H, Ardinger H, Prasad C, Dobyns WB, Millen KJ (October 2004). "Heterozygous deletion of the linked genes ZIC1 and ZIC4 is involved in Dandy-Walker malformation". Nat Genet. 36 (10): 1053–5. doi: 10.1038/ng1420 . PMID 15338008.
1 2 Koyabu Y, Nakata K, Mizugishi K, Aruga J, Mikoshiba K (March 2001). "Physical and functional interactions between Zic and Gli proteins". J. Biol. Chem. 276 (10). United States: 6889–92. doi: 10.1074/jbc.C000773200 . ISSN 0021-9258. PMID 11238441.

ZIC1

Contents

Interactions

Related Research Articles

References

Further reading