ZIC1 is a member of the Zinc finger of the cerebellum (ZIC) protein family. [5] [6]
ZIC1 is classified as a ZIC protein due to conservation of the five C2H2 zinc fingers, which enables the protein to interact with DNA and proteins. ZIC1 is found in close genomic configuration in another member of this protein family, ZIC4. Correct function of these proteins is critical for early development, and as such mutations of the genes encoding these proteins is known to result in various congenital defects. For example, if function of both ZIC1 and ZIC4 is lost (which can occur via an interstitial deletion due to their adjacent location) then this may result in the Dandy–Walker malformation. [7]
Zinc finger protein GLI1 also known as glioma-associated oncogene is a protein that in humans is encoded by the GLI1 gene. It was originally isolated from human glioblastoma cells.
Zinc finger protein GLI2 also known as GLI family zinc finger 2 is a protein that in humans is encoded by the GLI2 gene. The protein encoded by this gene is a transcription factor.
Zinc finger protein GLI3 is a protein that in humans is encoded by the GLI3 gene.
Suppressor of fused homolog is a protein that in humans is encoded by the SUFU gene. In molecular biology, the protein domain suppressor of fused protein (Sufu) has an important role in the cell. The Sufu is important in negatively regulating an important signalling pathway in the cell, the Hedgehog signalling pathway (HH). This particular pathway is crucial in embryonic development. There are several homologues of Sufu, found in a wide variety of organisms.
ZIC3 is a member of the Zinc finger of the cerebellum (ZIC) protein family.
Zinc finger protein 40 is a protein that in humans is encoded by the HIVEP1 gene.
Krueppel-like factor 12 is a protein that in humans is encoded by the KLF12 gene.
Zinc finger protein ZIC2 is a protein that in humans is encoded by the ZIC2 gene. ZIC2 is a member of the Zinc finger of the cerebellum (ZIC) protein family.
POZ-, AT hook-, and zinc finger-containing protein 1 is a protein that in humans is encoded by the PATZ1 gene.
Zinc finger protein 143 is a protein that in humans is encoded by the ZNF143 gene.
Zinc finger protein 219 is a protein that in humans is encoded by the ZNF219 gene.
Protein Jade-3 is a protein that in humans is encoded by the PHF16 gene.
Zinc finger protein 267 is a protein that in humans is encoded by the ZNF267 gene.
Zinc fingers and homeoboxes protein 2 is a protein that in humans is encoded by the ZHX2 gene.
Krüppel-like factor 3 is a protein that in humans is encoded by the KLF3 gene.
Zinc finger protein 57 homolog (ZFP57), also known as zinc finger protein 698 (ZNF698), is a protein that in humans is encoded by the ZFP57 gene.
Early growth response protein 4 (EGR-4), also known as AT133, is a protein that in humans is encoded by the EGR4 gene.
Glis1 is gene encoding a Krüppel-like protein of the same name whose locus is found on Chromosome 1p32.3. The gene is enriched in unfertilised eggs and embryos at the one cell stage and it can be used to promote direct reprogramming of somatic cells to induced pluripotent stem cells, also known as iPS cells. Glis1 is a highly promiscuous transcription factor, regulating the expression of numerous genes, either positively or negatively. In organisms, Glis1 does not appear to have any directly important functions. Mice whose Glis1 gene has been removed have no noticeable change to their phenotype.
Zinc finger protein 444 is a protein that in humans is encoded by the ZNF444 gene.
ZIC5 is a member of the Zinc finger of the cerebellum (ZIC) protein family. ZIC5 is located on chromosome 13 in a divergently transcribed gene pair with the closely related gene ZIC2. It has been suggested that this tandem arrangement allows ZIC2 and ZIC5 to share regulatory elements and causes the two genes to have very similar expression patterns.