ZM447439

ZM447439
Names
	Preferred IUPAC name N-[4-({6-Methoxy-7-[3-(morpholin-4-yl)propoxy]quinazolin-4-yl}amino)phenyl]benzamide
Identifiers
CAS Number	331771-20-1 ;
3D model (JSmol)	Interactive image ;
ChEBI	CHEBI:91376 ;
ChemSpider	8090061 ;
PubChem CID	9914412 ;
UNII	RSN3P9776R ;
CompTox Dashboard (EPA)	DTXSID00186833 ;
	InChI InChI=1S/C29H31N5O4/c1-36-26-18-24-25(19-27(26)38-15-5-12-34-13-16-37-17-14-34)30-20-31-28(24)32-22-8-10-23(11-9-22)33-29(35)21-6-3-2-4-7-21/h2-4,6-11,18-20H,5,12-17H2,1H3,(H,33,35)(H,30,31,32) Key: OGNYUTNQZVRGMN-UHFFFAOYSA-N ; InChI=1/C29H31N5O4/c1-36-26-18-24-25(19-27(26)38-15-5-12-34-13-16-37-17-14-34)30-20-31-28(24)32-22-8-10-23(11-9-22)33-29(35)21-6-3-2-4-7-21/h2-4,6-11,18-20H,5,12-17H2,1H3,(H,33,35)(H,30,31,32) Key: OGNYUTNQZVRGMN-UHFFFAOYAS;
	SMILES COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)NC(=O)C4=CC=CC=C4)OCCCN5CCOCC5;
Properties
Chemical formula	C29H31N5O4
Molar mass	513.598 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Last updated September 03, 2025

ZM447439 is an aurora inhibitor.^[1]

References

↑ Georgieva, I.; Koychev, D.; Wang, Y.; Holstein, J.; Hopfenmüller, W.; Zeitz, M.; Grabowski, P. (2010). "ZM447439, a Novel Promising Aurora Kinase Inhibitor, Provokes Antiproliferative and Proapoptotic Effects Alone and in Combination with Bio- and Chemotherapeutic Agents in Gastroenteropancreatic Neuroendocrine Tumor Cell Lines". Neuroendocrinology. 91 (2): 121–130. doi:10.1159/000258705. PMID 19923785. S2CID 1042055.

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[1] Georgieva, I.; Koychev, D.; Wang, Y.; Holstein, J.; Hopfenmüller, W.; Zeitz, M.; Grabowski, P. (2010). "ZM447439, a Novel Promising Aurora Kinase Inhibitor, Provokes Antiproliferative and Proapoptotic Effects Alone and in Combination with Bio- and Chemotherapeutic Agents in Gastroenteropancreatic Neuroendocrine Tumor Cell Lines". Neuroendocrinology. 91 (2): 121–130. doi:10.1159/000258705. PMID 19923785. S2CID 1042055.

[1]

Names

Preferred IUPAC name N-[4-({6-Methoxy-7-[3-(morpholin-4-yl)propoxy]quinazolin-4-yl}amino)phenyl]benzamide
Identifiers
CAS Number	331771-20-1 ^Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:91376
ChemSpider	8090061 ^N
PubChem CID	9914412
UNII	RSN3P9776R ^Y
CompTox Dashboard (EPA)	DTXSID00186833
InChI InChI=1S/C29H31N5O4/c1-36-26-18-24-25(19-27(26)38-15-5-12-34-13-16-37-17-14-34)30-20-31-28(24)32-22-8-10-23(11-9-22)33-29(35)21-6-3-2-4-7-21/h2-4,6-11,18-20H,5,12-17H2,1H3,(H,33,35)(H,30,31,32)^N Key: OGNYUTNQZVRGMN-UHFFFAOYSA-N^N InChI=1/C29H31N5O4/c1-36-26-18-24-25(19-27(26)38-15-5-12-34-13-16-37-17-14-34)30-20-31-28(24)32-22-8-10-23(11-9-22)33-29(35)21-6-3-2-4-7-21/h2-4,6-11,18-20H,5,12-17H2,1H3,(H,33,35)(H,30,31,32) Key: OGNYUTNQZVRGMN-UHFFFAOYAS
SMILES COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)NC(=O)C4=CC=CC=C4)OCCCN5CCOCC5
Properties
Chemical formula	C₂₉H₃₁N₅O₄
Molar mass	513.598 g·mol⁻¹
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is ^YN ?) Infobox references