 | |
| Names | |
|---|---|
| Preferred IUPAC name N-[4-({6-Methoxy-7-[3-(morpholin-4-yl)propoxy]quinazolin-4-yl}amino)phenyl]benzamide | |
| Identifiers | |
3D model (JSmol) | |
| ChEBI | |
| ChemSpider | |
PubChem CID | |
| UNII | |
CompTox Dashboard (EPA) | |
| |
| |
| Properties | |
| C29H31N5O4 | |
| Molar mass | 513.598 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
ZM447439 is an aurora inhibitor. [1]
The Lancia 1Z and the Lancia 1ZM were two variations of an Italian armoured car built during World War I and which saw limited service during that war, the interwar period, and during World War II. The name is often misspelled as Lancia IZM.
ZM is a New Zealand contemporary hit radio network owned by New Zealand Media and Entertainment. It broadcasts 19 markets throughout mainland New Zealand via terrestrial FM, and worldwide via the Internet. The network targets the 15–39 demographic specialises in a chart-music playlist of pop, rock, hip hop and dance music. It reaches approximately 486,800 listeners weekly, making it the fifth largest commercial radio station in New Zealand.
.zm is the Internet country code top-level domain (ccTLD) for Zambia. Registrants of .zm domains must "have a presence in Zambia".
Aurora kinases are serine/threonine kinases that are essential for cell proliferation. They are phosphotransferase enzymes that help the dividing cell dispense its genetic materials to its daughter cells. More specifically, Aurora kinases play a crucial role in cellular division by controlling chromatid segregation. Defects in this segregation can cause genetic instability, a condition which is highly associated with tumorigenesis. The first aurora kinases were identified in Drosophila melanogaster, where mutations led to failure of centrosome separation with the monopolar spindles reminiscent of the North Pole, suggesting the name aurora.
MS Arcadia is a cruise ship in the P&O Cruises fleet. The ship was built by Fincantieri at their shipyard in Marghera, Italy. At over 84,000 gross tonnage (GT), Arcadia is the second smallest of seven ships currently in service with P&O Cruises. The ship officially entered service with the company in April 2005 and was named by Dame Kelly Holmes.
Cyclacel Pharmaceuticals Inc. is a biotechnology firm based in Berkeley Heights, New Jersey and Dundee, Scotland, developing cancer treatments. Cyclacel was founded in 1996 by David Lane, PhD.
Trilostane, sold under the brand names Modrenal and Vetoryl among others, is a medication which has been used in the treatment of Cushing's syndrome, Conn's syndrome, and postmenopausal breast cancer in humans. It was withdrawn for use in humans in the United States in the 1990s but was subsequently approved for use in veterinary medicine in the 2000s to treat Cushing's syndrome in dogs. It is taken by mouth.
Aurora kinase A also known as serine/threonine-protein kinase 6 is an enzyme that in humans is encoded by the AURKA gene.
Zymomonas mobilis is a Gram negative, facultative anaerobic, non-sporulating, polarly-flagellated, rod-shaped bacterium. It is the only species found in the genus Zymomonas. It has notable bioethanol-producing capabilities, which surpass yeast in some aspects. It was originally isolated from alcoholic beverages like the African palm wine, the Mexican pulque, and also as a contaminant of cider and beer in European countries.
Aurora kinase B is a protein that functions in the attachment of the mitotic spindle to the centromere.
Aurora kinase inhibitors are a putative drug class for treating cancer. The Aurora kinase enzymes could be potential targets for novel small-molecule enzyme inhibitors.
ISO 3166-2:ZM is the entry for Zambia in ISO 3166-2, part of the ISO 3166 standard published by the International Organization for Standardization (ISO), which defines codes for the names of the principal subdivisions of all countries coded in ISO 3166-1.
ZM-241,385 is a high affinity antagonist ligand selective for the adenosine A2A receptor.
MRS-1706 is a selective inverse agonist for the adenosine A2B receptor. It inhibits release of interleukins and has an antiinflammatory effect.
SU6656 is a Src family kinase inhibitor developed by the biotechnology company SUGEN Inc in 2000. SU6656 was initially identified as a Src kinase inhibitor by virtue of its ability to reverse an effect that an activated mutant form of Src has on the actin cytoskeleton, namely the formation of podosome rosettes, otherwise known as invadopodia. SU6656 was initially published as a Src family kinase inhibitor with selectivity relative to Platelet-derived growth factor receptor Tyrosine kinase. Subsequent studies have confirmed that SU6656 is relatively selective for Src family kinases, but some additional biochemical activities have been identified including: BRSK2, AMPK, Aurora C, Aurora B, CaMKKβ. The inhibition of these kinases in biochemical reactions in vitro does not necessarily indicate that these kinases are targets of SU6656 in cells.
BI 811283 is a small molecule inhibitor of the Aurora B kinase protein being developed by Boehringer Ingelheim for use as an anti-cancer agent. BI 811283 is currently in the early stages of clinical development and is undergoing first in human trials in patients with solid tumors and acute myeloid leukemia.
Hesperadin is an aurora kinase inhibitor.
The African Youth Athletics Championships is a biennial continental athletics competition for African athletes, organised by the Confederation of African Athletics. First held in 2013, it is a youth category event open to athletes aged fifteen to seventeen in the year of competition.
Alisertib (MLN8237) is an orally available selective aurora A kinase inhibitor developed by Takeda. It was investigated as a treatment for relapsed or refractory peripheral T-cell lymphoma. Development was abandoned in 2015 due to poor clinical trial results.
ZM-182345 is a nonsteroidal progestin that was never marketed. It was derived from structural modification of the nonsteroidal antiandrogen hydroxyflutamide. ZM-182345 was found to be at least as potent as progesterone as a progestogen in animals but to also possess androgenic activity.
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