ZMYM2

ZMYM2
Identifiers
Aliases	ZMYM2 , FIM, MYM, RAMP, SCLL, ZNF198, zinc finger MYM-type containing 2, NECRC
External IDs	OMIM: 602221; MGI: 1923257; HomoloGene: 12631; GeneCards: ZMYM2; OMA:ZMYM2 - orthologs
Gene location (Human) Chr. Chromosome 13 (human) [1] Band 13q12.11 Start 19,958,677 bp [1] End 20,091,829 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14|14 C3 Start 57,124,110 bp [2] End 57,200,158 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm oocyte secondary oocyte ganglionic eminence buccal mucosa cell right testis Achilles tendon left testis testicle ventricular zone Top expressed in hand genital tubercle tail of embryo spermatocyte ganglionic eminence ventricular zone medial ganglionic eminence epiblast neural layer of retina abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function zinc ion binding metal ion binding ubiquitin conjugating enzyme binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA binding protein tyrosine kinase activity protein binding Cellular component cytosol nucleus PML body cytoplasm nucleoplasm Biological process regulation of transcription, DNA-templated transcription, DNA-templated cytoskeleton organization regulation of cell morphogenesis multicellular organism development peptidyl-tyrosine phosphorylation regulation of transcription by RNA polymerase II biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7750 76007 Ensembl ENSG00000121741 ENSMUSG00000021945 UniProt Q9UBW7 Q9CU65 RefSeq (mRNA) NM_001190964 NM_001190965 NM_003453 NM_197968 NM_001353157 NM_001353159 NM_001353161 NM_001353162 NM_001353163 NM_001353164 NM_001353165 NM_029498 NM_177627 NM_001360643 RefSeq (protein) NP_001177893 NP_001177894 NP_003444 NP_932072 NP_001340086 NP_001340088 NP_001340090 NP_001340091 NP_001340092 NP_001340093 NP_001340094 NP_083774 NP_001347572 NP_808295 Location (UCSC) Chr 13: 19.96 – 20.09 Mb Chr 14: 57.12 – 57.2 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Zinc finger MYM-type protein 2 is a protein that in humans is encoded by the ZMYM2 gene. ^{[5] [6] [7]}

See also

• Chromosome 13 (human)
• Myeloproliferative neoplasm
• Zinc finger protein

References

1. GRCh38: Ensembl release 89: ENSG00000121741 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021945 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Smedley D, Hamoudi R, Clark J, Warren W, Abdul-Rauf M, Somers G, Venter D, Fagan K, Cooper C, Shipley J (April 1998). "The t(8;13)(p11;q11-12) rearrangement associated with an atypical myeloproliferative disorder fuses the fibroblast growth factor receptor 1 gene to a novel gene RAMP". Human Molecular Genetics. 7 (4): 637–42. doi: 10.1093/hmg/7.4.637 . PMID   9499416.
6. Xiao S, Nalabolu SR, Aster JC, Ma J, Abruzzo L, Jaffe ES, Stone R, Weissman SM, Hudson TJ, Fletcher JA (January 1998). "FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome". Nature Genetics. 18 (1): 84–7. doi:10.1038/ng0198-84. PMID   9425908. S2CID   826758.
7. "Entrez Gene: ZMYM2 zinc finger, MYM-type 2".

Further reading

• Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Popovici C, Adélaïde J, Ollendorff V, Chaffanet M, Guasch G, Jacrot M, Leroux D, Birnbaum D, Pébusque MJ (May 1998). "Fibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloproliferative disorder with t(8;13)". Proceedings of the National Academy of Sciences of the United States of America. 95 (10): 5712–7. doi: 10.1073/pnas.95.10.5712 . PMC   20444 . PMID   9576949.
• Still IH, Cowell JK (August 1998). "The t(8;13) atypical myeloproliferative disorder: further analysis of the ZNF198 gene and lack of evidence for multiple genes disrupted on chromosome 13". Blood. 92 (4): 1456–8. doi:10.1182/blood.V92.4.1456.splL3_1456_1458. PMID   9694738.
• Reiter A, Sohal J, Kulkarni S, Chase A, Macdonald DH, Aguiar RC, Gonçalves C, Hernandez JM, Jennings BA, Goldman JM, Cross NC (September 1998). "Consistent fusion of ZNF198 to the fibroblast growth factor receptor-1 in the t(8;13)(p11;q12) myeloproliferative syndrome". Blood. 92 (5): 1735–42. doi:10.1182/blood.V92.5.1735. PMID   9716603.
• Kulkarni S, Reiter A, Smedley D, Goldman JM, Cross NC (January 1999). "The genomic structure of ZNF198 and location of breakpoints in the t(8;13) myeloproliferative syndrome". Genomics. 55 (1): 118–21. doi:10.1006/geno.1998.5634. PMID   9889006.
• Ollendorff V, Guasch G, Isnardon D, Galindo R, Birnbaum D, Pébusque MJ (September 1999). "Characterization of FIM-FGFR1, the fusion product of the myeloproliferative disorder-associated t(8;13) translocation". The Journal of Biological Chemistry. 274 (38): 26922–30. doi: 10.1074/jbc.274.38.26922 . PMID   10480903.
• Matsumoto K, Morita K, Takada S, Sakura T, Shiozaki H, Murakami H, Miyawaki S (December 1999). "A chronic myelogenous leukemia-like myeloproliferative disorder accompanied by T-cell lymphoblastic lymphoma with chromosome translocation t(8;13)(p11;q12): a Japanese case". International Journal of Hematology. 70 (4): 278–82. PMID   10643154.
• Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (September 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R (February 2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes". The Journal of Biological Chemistry. 278 (9): 7234–9. doi: 10.1074/jbc.M208992200 . PMID   12493763.
• Baumann H, Kunapuli P, Tracy E, Cowell JK (May 2003). "The oncogenic fusion protein-tyrosine kinase ZNF198/fibroblast growth factor receptor-1 has signaling function comparable with interleukin-6 cytokine receptors". The Journal of Biological Chemistry. 278 (18): 16198–208. doi: 10.1074/jbc.M300018200 . PMID   12594223.
• Kunapuli P, Somerville R, Still IH, Cowell JK (May 2003). "ZNF198 protein, involved in rearrangement in myeloproliferative disease, forms complexes with the DNA repair-associated HHR6A/6B and RAD18 proteins". Oncogene. 22 (22): 3417–23. doi:10.1038/sj.onc.1206408. PMID   12776193. S2CID   21536204.
• Warner DR, Roberts EA, Greene RM, Pisano MM (December 2003). "Identification of novel Smad binding proteins". Biochemical and Biophysical Research Communications. 312 (4): 1185–90. doi:10.1016/j.bbrc.2003.11.049. PMID   14651998.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (July 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.