ZNF160

ZNF160
Identifiers
Aliases	ZNF160 , F11, HKr18, HZF5, KR18, zinc finger protein 160
External IDs	OMIM: 600398 HomoloGene: 131121 GeneCards: ZNF160
Gene location (Human)
Chr.	Chromosome 19 (human)
End	53,103,434 bp
RNA expression pattern
	Top expressed in
	renal medulla; ; endothelial cell; ; pylorus; ; nipple; ; ventral tegmental area; ; visceral pleura; ; cardia; ; sperm; ; superior surface of tongue; ; trigeminal ganglion;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding ; metal ion binding ; nucleic acid binding ; DNA-binding transcription factor activity, RNA polymerase II-specific ;
Cellular component	intracellular anatomical structure ; nucleus ;
Biological process	regulation of transcription, DNA-templated ; transcription, DNA-templated ; regulation of transcription by RNA polymerase II ; hemopoiesis ;
	Sources:Amigo / QuickGO
Orthologs
	90338
	n/a
	ENSG00000170949
	n/a
	Q9HCG1
	n/a
NM_001102603 ; NM_033288 ; NM_198893 ; NM_001322125 ; NM_001322126 ;
	NM_001322128 ; NM_001322129 ; NM_001322130 ; NM_001322131 ; NM_001322132 ; NM_001322133 ; NM_001322134 ; NM_001322135 ; NM_001322136 ; NM_001322137 ; NM_001322138 ; NM_001322139
	n/a
NP_001096073 ; NP_001309054 ; NP_001309055 ; NP_001309057 ; NP_001309058 ;
	NP_001309059 ; NP_001309060 ; NP_001309061 ; NP_001309062 ; NP_001309063 ; NP_001309064 ; NP_001309065 ; NP_001309066 ; NP_001309067 ; NP_001309068 ; NP_150630 ; NP_942596
	n/a
	Wikidata
View/Edit Human

Last updated September 30, 2022

Zinc finger protein 160 is a protein that, in humans, is encoded by the ZNF160 gene.^[3]^[4]^[5]

The protein encoded by this gene is a Krüppel-related zinc finger protein which is characterized by the presence of an N-terminal repressor domain, the Kruppel-associated box (KRAB). The KRAB domain is a potent repressor of transcription; thus this protein may function in transcription regulation. Two alternative transcripts encoding the same isoform have been described.^[5]

Related Research Articles

The Krüppel associated box (KRAB) domain is a category of transcriptional repression domains present in approximately 400 human zinc finger protein-based transcription factors. The KRAB domain typically consists of about 75 amino acid residues, while the minimal repression module is approximately 45 amino acid residues. It is predicted to function through protein-protein interactions via two amphipathic helices. The most prominent interacting protein is called TRIM28 initially visualized as SMP1, cloned as KAP1 and TIF1-beta. Substitutions for the conserved residues abolish repression.

Zinc fingers and homeoboxes protein 3 is a protein that in humans is encoded by the ZHX3 gene.

Zinc finger protein 10 is a protein that in humans is encoded by the ZNF10 gene.

Zinc finger protein 274 is a protein that in humans is encoded by the ZNF274 gene.

Zinc finger protein 219 is a protein that in humans is encoded by the ZNF219 gene.

Zinc finger protein with KRAB and SCAN domains 1 is a protein that in humans is encoded by the ZKSCAN1 gene.

Zinc finger protein 267 is a protein that in humans is encoded by the ZNF267 gene.

Zinc finger protein 41 is a protein that in humans is encoded by the ZNF41 gene.

Zinc finger protein 268 is a protein that in humans is encoded by the ZNF268 gene.

Zinc finger protein 423 is a protein that in humans is encoded by the ZNF423 gene.

Zinc finger protein 331 is a protein that in humans is encoded by the ZNF331 gene.

Zinc finger protein 83 is a protein that in humans is encoded by the ZNF83 gene.

Zinc finger protein 23 is a protein that in humans is encoded by the ZNF23 gene.

Zinc finger protein 133 is a protein that in humans is encoded by the ZNF133 gene.

Zinc finger protein 224 is a protein that in humans is encoded by the ZNF224 gene.

Zinc finger protein 436 is a protein that in humans is encoded by the ZNF436 gene.

Zinc finger protein 264 is a protein that in humans is encoded by the ZNF264 gene.

Zinc finger protein 184, also known as ZNF184, is a protein that in humans is encoded by the ZNF184 gene on chromosome 6. It was first identified by Goldwurm et al. in 1996.

Zinc finger protein 266 is a protein that in humans is encoded by the ZNF266 gene.

Zinc Finger Protein 548 (ZNF548) is a human protein encoded by the ZNF548 gene which is located on chromosome 19. It is found in the nucleus and is hypothesized to play a role in the regulation of transcription by RNA Polymerase II. It belongs to the Krüppel C2H2-type zinc-finger protein family as it contains many zinc-finger repeats.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000170949 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Halford S, Mattei MG, Daw S, Scambler PJ (Jul 1995). "A novel C2H2 zinc-finger protein gene (ZNF160) maps to human chromosome 19q13.3-q13.4". Genomics. 25 (1): 322–3. doi:10.1016/0888-7543(95)80149-G. PMID 7774943.
↑ Abrink M, Aveskogh M, Hellman L (Mar 1995). "Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937". DNA Cell Biol. 14 (2): 125–36. doi:10.1089/dna.1995.14.125. PMID 7865130.
1 2 "Entrez Gene: ZNF160 zinc finger protein 160".

Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Mark C, Looman C, Abrink M, Hellman L (2001). "Molecular cloning and preliminary functional analysis of two novel human KRAB zinc finger proteins, HKr18 and HKr19". DNA Cell Biol. 20 (5): 275–86. doi:10.1089/104454901750232472. PMID 11410164.
Hattori A, Okumura K, Nagase T, et al. (2001). "Characterization of long cDNA clones from human adult spleen". DNA Res. 7 (6): 357–66. doi: 10.1093/dnares/7.6.357 . PMID 11214971.
Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi: 10.1093/dnares/7.4.271 . PMID 10997877.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000170949 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7774943-3] Halford S, Mattei MG, Daw S, Scambler PJ (Jul 1995). "A novel C2H2 zinc-finger protein gene (ZNF160) maps to human chromosome 19q13.3-q13.4". Genomics. 25 (1): 322–3. doi:10.1016/0888-7543(95)80149-G. PMID 7774943.

[pmid7865130-4] Abrink M, Aveskogh M, Hellman L (Mar 1995). "Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937". DNA Cell Biol. 14 (2): 125–36. doi:10.1089/dna.1995.14.125. PMID 7865130.

[entrez-5] 1 2 "Entrez Gene: ZNF160 zinc finger protein 160".

[1]

[2]

[3]

[4]

[5]

ZNF160

Related Research Articles

References

Further reading