ZNF160

ZNF160
Identifiers
Aliases	ZNF160 , F11, HKr18, HZF5, KR18, zinc finger protein 160
External IDs	OMIM: 600398; HomoloGene: 131121; GeneCards: ZNF160; OMA:ZNF160 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.41-q13.42 Start 53,066,606 bp [1] End 53,103,434 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla endothelial cell pylorus nipple ventral tegmental area visceral pleura cardia sperm superior surface of tongue trigeminal ganglion n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component intracellular anatomical structure nucleus Biological process regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II hemopoiesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 90338 n/a Ensembl ENSG00000170949 n/a UniProt Q9HCG1 n/a RefSeq (mRNA) NM_001102603 NM_033288 NM_198893 NM_001322125 NM_001322126 NM_001322128 NM_001322129 NM_001322130 NM_001322131 NM_001322132 NM_001322133 NM_001322134 NM_001322135 NM_001322136 NM_001322137 NM_001322138 NM_001322139 n/a RefSeq (protein) NP_001096073 NP_001309054 NP_001309055 NP_001309057 NP_001309058 NP_001309059 NP_001309060 NP_001309061 NP_001309062 NP_001309063 NP_001309064 NP_001309065 NP_001309066 NP_001309067 NP_001309068 NP_150630 NP_942596 n/a Location (UCSC) Chr 19: 53.07 – 53.1 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Zinc finger protein 160 is a protein that, in humans, is encoded by the ZNF160 gene. ^{[3] [4] [5]}

The protein encoded by this gene is a Krüppel-related zinc finger protein which is characterized by the presence of an N-terminal repressor domain, the Kruppel-associated box (KRAB). The KRAB domain is a potent repressor of transcription; thus this protein may function in transcription regulation. Two alternative transcripts encoding the same isoform have been described. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000170949 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Halford S, Mattei MG, Daw S, Scambler PJ (Jul 1995). "A novel C2H2 zinc-finger protein gene (ZNF160) maps to human chromosome 19q13.3-q13.4". Genomics. 25 (1): 322–3. doi:10.1016/0888-7543(95)80149-G. PMID   7774943.
4. Abrink M, Aveskogh M, Hellman L (Mar 1995). "Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937". DNA Cell Biol. 14 (2): 125–36. doi:10.1089/dna.1995.14.125. PMID   7865130.
5. "Entrez Gene: ZNF160 zinc finger protein 160".

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Mark C, Looman C, Abrink M, Hellman L (2001). "Molecular cloning and preliminary functional analysis of two novel human KRAB zinc finger proteins, HKr18 and HKr19". DNA Cell Biol. 20 (5): 275–86. doi:10.1089/104454901750232472. PMID   11410164.
• Hattori A, Okumura K, Nagase T, et al. (2001). "Characterization of long cDNA clones from human adult spleen". DNA Res. 7 (6): 357–66. doi: 10.1093/dnares/7.6.357 . PMID   11214971.
• Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi: 10.1093/dnares/7.4.271 . PMID   10997877.