ZNF224

ZNF224
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2ELY, 2ELZ, 2EM0, 2EM6, 2EM7, 2EM8, 2EM9, 2EN1, 2EN8, 2ENA, 2ENC, 2EOQ, 2EOR, 2EQ4, 2YSP, 2YTH
Identifiers
Aliases	ZNF224 , BMZF-2, BMZF2, KOX22, ZNF255, ZNF27, ZNF233, zinc finger protein 224
External IDs	OMIM: 194555 HomoloGene: 130663 GeneCards: ZNF224
Gene location (Human)
Chr.	Chromosome 19 (human)
End	44,109,886 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; rectum; ; gastric mucosa; ; right uterine tube; ; spleen; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; right lung; ; lymph node; ; sural nerve;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; nucleic acid binding ; DNA-binding transcription factor activity ; metal ion binding ; DNA binding ; DNA-binding transcription repressor activity, RNA polymerase II-specific ; sequence-specific DNA binding ; DNA-binding transcription factor activity, RNA polymerase II-specific ;
Cellular component	nucleus ; intracellular anatomical structure ; nuclear membrane ; transcription repressor complex ;
Biological process	negative regulation of transcription, DNA-templated ; regulation of transcription, DNA-templated ; transcription, DNA-templated ; negative regulation of transcription by RNA polymerase II ;
	Sources:Amigo / QuickGO
Orthologs
	7767
	n/a
	ENSG00000267680
	n/a
	Q9NZL3
	n/a
	NM_013398 ; NM_001321645
	n/a
	NP_001308574 ; NP_037530
	n/a
	Wikidata
View/Edit Human

Last updated September 30, 2022

Zinc finger protein 224 is a protein that in humans is encoded by the ZNF224 gene.^[3]

Related Research Articles

The Krüppel associated box (KRAB) domain is a category of transcriptional repression domains present in approximately 400 human zinc finger protein-based transcription factors. The KRAB domain typically consists of about 75 amino acid residues, while the minimal repression module is approximately 45 amino acid residues. It is predicted to function through protein-protein interactions via two amphipathic helices. The most prominent interacting protein is called TRIM28 initially visualized as SMP1, cloned as KAP1 and TIF1-beta. Substitutions for the conserved residues abolish repression.

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000267680 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: ZNF224 zinc finger protein 224".

Medugno L, Florio F, Cesaro E, et al. (2007). "Differential expression and cellular localization of ZNF224 and ZNF255, two isoforms of the Krüppel-like zinc-finger protein family". Gene. 403 (1–2): 125–131. doi:10.1016/j.gene.2007.07.036. PMID 17900823.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–12135. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935.
Shannon M, Hamilton AT, Gordon L, et al. (2003). "Differential Expansion of Zinc-Finger Transcription Factor Loci in Homologous Human and Mouse Gene Clusters". Genome Res. 13 (6A): 1097–1110. doi:10.1101/gr.963903. PMC 403638 . PMID 12743021.
Medugno L, Costanzo P, Lupo A, et al. (2004). "A novel zinc finger transcriptional repressor, ZNF224, interacts with the negative regulatory element (AldA-NRE) and inhibits gene expression". FEBS Lett. 534 (1–3): 93–100. doi: 10.1016/S0014-5793(02)03783-3 . PMID 12527367. S2CID 3087490.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Lee TH, Lwu S, Kim J, Pelletier J (2003). "Inhibition of Wilms tumor 1 transactivation by bone marrow zinc finger 2, a novel transcriptional repressor". J. Biol. Chem. 277 (47): 44826–44837. doi: 10.1074/jbc.M205667200 . PMID 12239212.
Han ZG, Zhang QH, Ye M, et al. (2000). "Molecular cloning of six novel Krüppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB". J. Biol. Chem. 274 (50): 35741–35748. doi: 10.1074/jbc.274.50.35741 . PMID 10585455.
Thiesen HJ (1991). "Multiple genes encoding zinc finger domains are expressed in human T cells". New Biol. 2 (4): 363–374. PMID 2288909.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000267680 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: ZNF224 zinc finger protein 224".

[1]

[2]

[3]

ZNF224

Related Research Articles

References

Further reading