ZRSR2

ZRSR2
Identifiers
Aliases	ZRSR2 , U2AF1-RS2, U2AF1L2, U2AF1RS2, URP, ZC3H22, zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2
External IDs	OMIM: 300028; MGI: 103287; HomoloGene: 21061; GeneCards: ZRSR2; OMA:ZRSR2 - orthologs
Gene location (Human) Chr. X chromosome (human) [1] Band Xp22.2 Start 15,790,156 bp [1] End 15,830,694 bp [1]
Gene location (Mouse) Chr. X chromosome (mouse) [2] Band X F5|X 75.99 cM Start 162,718,439 bp [2] End 162,741,657 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve granulocyte monocyte tendon of biceps brachii external globus pallidus tibial arteries spleen gastric mucosa Descending thoracic aorta lymph node Top expressed in genital tubercle tail of embryo yolk sac retinal pigment epithelium zygote primitive streak embryo Epithelium of choroid plexus granulocyte muscle of thigh More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding nucleic acid binding pre-mRNA 3'-splice site binding RNA binding protein binding Cellular component nucleus spliceosomal complex U12-type spliceosomal complex nucleoplasm U2AF complex Biological process mRNA processing spliceosomal complex assembly RNA splicing mRNA splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8233 22184 Ensembl ENSG00000169249 ENSMUSG00000031370 UniProt Q15696 Q62377 RefSeq (mRNA) NM_005089 NM_009453 NM_178794 RefSeq (protein) NP_005080 n/a Location (UCSC) Chr X: 15.79 – 15.83 Mb Chr X: 162.72 – 162.74 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 is a protein that in humans is encoded by the ZRSR2 gene. ^{[5] [6] [7] [8]}

This gene encodes an essential splicing factor. The encoded protein associates with the U2 auxiliary factor heterodimer, which is required for the recognition of a functional 3' splice site in pre-mRNA splicing, and may play a role in network interactions during spliceosome assembly. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000169249 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031370 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kitagawa K, Wang X, Hatada I, Yamaoka T, Nojima H, Inazawa J, Abe T, Mitsuya K, Oshimura M, Murata A, et al. (Mar 1996). "Isolation and mapping of human homologues of an imprinted mouse gene U2af1-rs1". Genomics. 30 (2): 257–63. doi:10.1006/geno.1995.9879. PMID   8586425.
6. Tronchere H, Wang J, Fu XD (Aug 1997). "A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA". Nature. 388 (6640): 397–400. Bibcode:1997Natur.388..397T. doi: 10.1038/41137 . PMID   9237760. S2CID   4386808.
7. Will CL, Schneider C, Hossbach M, Urlaub H, Rauhut R, Elbashir S, Tuschl T, Luhrmann R (May 2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome". RNA. 10 (6): 929–41. doi:10.1261/rna.7320604. PMC   1370585 . PMID   15146077.
8. "Entrez Gene: ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2".

Further reading

• Brunner B, Todt T, Lenzner S, et al. (1999). "Genomic structure and comparative analysis of nine Fugu genes: conservation of synteny with human chromosome Xp22.2-p22.1". Genome Res. 9 (5): 437–48. doi:10.1101/gr.9.5.437. PMC   310778 . PMID   10330123.
• Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID   10508479. S2CID   21839750.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.