ZRSR2

ZRSR2
Identifiers
Aliases	ZRSR2 , U2AF1-RS2, U2AF1L2, U2AF1RS2, URP, ZC3H22, zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2
External IDs	OMIM: 300028 MGI: 103287 HomoloGene: 21061 GeneCards: ZRSR2
Gene location (Human)
Chr.	X chromosome (human)
End	15,830,694 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	162,741,657 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; monocyte; ; external globus pallidus; ; spleen; ; gastric mucosa; ; lymph node; ; anterior pituitary; ; ascending aorta; ; Region I of hippocampus proper; ; cardia;
	Top expressed in
	yolk sac; ; retinal pigment epithelium; ; primitive streak; ; secondary oocyte; ; supraoptic nucleus; ; superior frontal gyrus; ; neural tube; ; facial motor nucleus; ; amygdala; ; paraventricular nucleus of hypothalamus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	metal ion binding ; nucleic acid binding ; pre-mRNA 3'-splice site binding ; RNA binding ; protein binding ;
Cellular component	nucleus ; spliceosomal complex ; U12-type spliceosomal complex ; nucleoplasm ; U2AF complex ;
Biological process	mRNA processing ; spliceosomal complex assembly ; RNA splicing ; mRNA splicing, via spliceosome ;
	Sources:Amigo / QuickGO
Orthologs
	8233
	22184
	ENSG00000169249
	ENSMUSG00000031370
	Q15696
	Q62377
	NM_005089
	NM_009453 ; NM_178794
	NP_005080
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 05, 2022

U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 is a protein that in humans is encoded by the ZRSR2 gene.^[5]^[6]^[7]^[8]

This gene encodes an essential splicing factor. The encoded protein associates with the U2 auxiliary factor heterodimer, which is required for the recognition of a functional 3' splice site in pre-mRNA splicing, and may play a role in network interactions during spliceosome assembly.^[8]

Related Research Articles

Splicing factor U2AF 65 kDa subunit is a protein that in humans is encoded by the U2AF2 gene.

Splicing factor 3 subunit 1 is a protein that in humans is encoded by the SF3A1 gene.

Splicing factor 1 also known as zinc finger protein 162 (ZFM162) is a protein that in humans is encoded by the SF1 gene.

Splicing factor 3A subunit 3 is a protein that in humans is encoded by the SF3A3 gene.

Aly/REF export factor, also known as THO complex subunit 4 is a protein that in humans is encoded by the ALYREF gene.

Splicing factor 3B subunit 3 is a protein that in humans is encoded by the SF3B3 gene.

Pre-mRNA-processing factor 6 is a protein that in humans is encoded by the PRPF6 gene.

U4/U6 small nuclear ribonucleoprotein Prp4 is a protein that in humans is encoded by the PRPF4 gene. The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors. PRPF4 is 1 of several proteins that associate with U4 and U6 snRNPs.[supplied by OMIM]

Survival of motor neuron-related-splicing factor 30 is a protein that in humans is encoded by the SMNDC1 gene.

Pre-mRNA-processing factor 17 is a protein that in humans is encoded by the CDC40 gene.

Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 is an enzyme that in humans is encoded by the DHX38 gene.

Splicing factor, arginine/serine-rich 12 is a protein that in humans is encoded by the SFRS12 gene.

Retinitis pigmentosa 9 , also known as RP9 or PAP-1, is a protein which in humans is encoded by the RP9 gene.

Splicing factor 45 is a protein that in humans is encoded by the RBM17 gene.

Probable ATP-dependent RNA helicase DDX23 is an enzyme that in humans is encoded by the DDX23 gene.

SFRS2-interacting protein is a protein that in humans is encoded by the SFRS2IP gene.

Splicing factor, arginine/serine-rich 11 is a protein that in humans is encoded by the SFRS11 gene.

Pre-mRNA-splicing factor SLU7 is a protein that in humans is encoded by the SLU7 gene.

Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 is an enzyme that in humans is encoded by the DHX15 gene.

Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 is an enzyme that in humans is encoded by the DHX16 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000169249 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031370 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kitagawa K, Wang X, Hatada I, Yamaoka T, Nojima H, Inazawa J, Abe T, Mitsuya K, Oshimura M, Murata A, et al. (Mar 1996). "Isolation and mapping of human homologues of an imprinted mouse gene U2af1-rs1". Genomics. 30 (2): 257–63. doi:10.1006/geno.1995.9879. PMID 8586425.
↑ Tronchere H, Wang J, Fu XD (Aug 1997). "A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA". Nature. 388 (6640): 397–400. Bibcode:1997Natur.388..397T. doi: 10.1038/41137 . PMID 9237760. S2CID 4386808.
↑ Will CL, Schneider C, Hossbach M, Urlaub H, Rauhut R, Elbashir S, Tuschl T, Luhrmann R (May 2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome". RNA. 10 (6): 929–41. doi:10.1261/rna.7320604. PMC 1370585 . PMID 15146077.
1 2 "Entrez Gene: ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2".

Brunner B, Todt T, Lenzner S, et al. (1999). "Genomic structure and comparative analysis of nine Fugu genes: conservation of synteny with human chromosome Xp22.2-p22.1". Genome Res. 9 (5): 437–48. doi:10.1101/gr.9.5.437. PMC 310778 . PMID 10330123.
Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456–64. doi: 10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5 . PMID 10508479.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000169249 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031370 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8586425-5] Kitagawa K, Wang X, Hatada I, Yamaoka T, Nojima H, Inazawa J, Abe T, Mitsuya K, Oshimura M, Murata A, et al. (Mar 1996). "Isolation and mapping of human homologues of an imprinted mouse gene U2af1-rs1". Genomics. 30 (2): 257–63. doi:10.1006/geno.1995.9879. PMID 8586425.

[pmid9237760-6] Tronchere H, Wang J, Fu XD (Aug 1997). "A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA". Nature. 388 (6640): 397–400. Bibcode:1997Natur.388..397T. doi: 10.1038/41137 . PMID 9237760. S2CID 4386808.

[pmid15146077-7] Will CL, Schneider C, Hossbach M, Urlaub H, Rauhut R, Elbashir S, Tuschl T, Luhrmann R (May 2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome". RNA. 10 (6): 929–41. doi:10.1261/rna.7320604. PMC 1370585 . PMID 15146077.

[entrez-8] 1 2 "Entrez Gene: ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2".

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ZRSR2

Related Research Articles

References

Further reading