Zinc finger protein 717

ZNF717
Identifiers
Aliases	ZNF717 , X17, ZNF838, zinc finger protein 717, OB1
External IDs	OMIM: 618405 MGI: 99183 HomoloGene: 69102 GeneCards: ZNF717
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3p12.3 Start 75,678,660 bp [1] End 75,785,583 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 B1.3 Start 58,778,979 bp [2] End 58,795,051 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube body of pancreas anterior pituitary skin of abdomen body of stomach secondary oocyte right lobe of liver left lobe of thyroid gland right lobe of thyroid gland islet of Langerhans Top expressed in spermatid spermatocyte seminiferous tubule cumulus cell sciatic nerve Paneth cell primitive streak proximal tubule ganglionic eminence substantia nigra More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component intracellular anatomical structure nucleus Biological process regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 100131827 22698 Ensembl ENSG00000227124 ENSMUSG00000037001 UniProt Q9BY31 Q02525 RefSeq (mRNA) NM_001128223 NM_001290208 NM_001290209 NM_001290210 NM_001324026 NM_001324027 NM_001324028 NM_011758 RefSeq (protein) NP_001121695 NP_001277137 NP_001277138 NP_001277139 NP_001310955 NP_001310956 NP_001310957 NP_035888 Location (UCSC) Chr 3: 75.68 – 75.79 Mb Chr 11: 58.78 – 58.8 Mb PubMed search [3] [4]
Wikidata
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Zinc finger protein 717 is a protein that in humans is encoded by the ZNF717 gene. ^[5]

Function

This gene encodes a Kruppel-associated box (KRAB) zinc-finger protein, which belongs to a large group of transcriptional regulators in mammals. These proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation and apoptosis, and in regulating viral replication and transcription. A pseudogene of this gene was identified on chromosome 1.

References

1. GRCh38: Ensembl release 89: ENSG00000227124 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037001 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Zinc finger protein 717" . Retrieved 2017-04-01.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.