ARL6

Last updated
ARL6
Protein ARL6 PDB 2h57.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ARL6 , BBS3, RP55, ADP-ribosylation factor-like 6, ADP ribosylation factor like GTPase 6
External IDs OMIM: 608845 MGI: 1927136 HomoloGene: 12960 GeneCards: ARL6
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001278293
NM_032146
NM_177976
NM_001323513
NM_001323514

Contents

NM_019665
NM_001347244

RefSeq (protein)

NP_001265222
NP_001310442
NP_001310443
NP_115522
NP_816931

NP_001334173
NP_062639

Location (UCSC) Chr 3: 97.76 – 97.8 Mb Chr 16: 59.43 – 59.46 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

ADP-ribosylation factor-like protein 6 is a protein that in humans is encoded by the ARL6 gene. [5] [6] [7]

The protein encoded by this gene belongs to the ARF family of GTP-binding proteins. ARF proteins are important regulators of cellular traffic and are the founding members of an expanding family of homologous proteins and genomic sequences. They depart from other small GTP-binding proteins by a unique structural device that implements front-back communication from the N-terminus to the nucleotide-binding site. Studies of the mouse ortholog of this protein suggest an involvement in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been described. [7]

Related Research Articles

<span class="mw-page-title-main">ARF1</span> Protein-coding gene in the species Homo sapiens

ADP-ribosylation factor 1 is a protein that in humans is encoded by the ARF1 gene.

<span class="mw-page-title-main">ARF5</span> Protein-coding gene in the species Homo sapiens

ADP-ribosylation factor 5 is a protein that in humans is encoded by the ARF5 gene.

<span class="mw-page-title-main">ARL3</span> Protein-coding gene in the species Homo sapiens

ADP-ribosylation factor-like protein 3 is a protein that in humans is encoded by the ARL3 gene.

<span class="mw-page-title-main">MKKS</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">ARL1</span> Protein-coding gene in humans

ADP-ribosylation factor-like protein 1 is a protein that in humans is encoded by the ARL1 gene.

<span class="mw-page-title-main">BBS1</span> Protein

Bardet–Biedl syndrome 1 protein is a protein that in humans is encoded by the BBS1 gene. BBS1 is part of the BBSome complex, which required for ciliogenesis. Mutations in this gene have been observed in patients with the major form of Bardet–Biedl syndrome.

<span class="mw-page-title-main">BBS5</span> Protein-coding gene in the species Homo sapiens

Bardet–Biedl syndrome 5 protein is a protein that in humans is encoded by the BBS5 gene.

<span class="mw-page-title-main">DDEF2</span> Protein-coding gene in the species Homo sapiens

Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the ASAP2 gene.

<span class="mw-page-title-main">BBS2</span> Protein-coding gene in the species Homo sapiens

Bardet–Biedl syndrome 2 protein is a protein that in humans is encoded by the BBS2 gene.

<span class="mw-page-title-main">ARFRP1</span> Protein-coding gene in the species Homo sapiens

ADP-ribosylation factor-related protein 1 is a protein that in humans is encoded by the ARFRP1 gene.

<span class="mw-page-title-main">ARL4D</span> Protein-coding gene in the species Homo sapiens

ADP-ribosylation factor-like protein 4D is a protein that in humans is encoded by the ARL4D gene.

<span class="mw-page-title-main">ARFGAP3</span> Protein-coding gene in the species Homo sapiens

ADP-ribosylation factor GTPase-activating protein 3 is a protein that in humans is encoded by the ARFGAP3 gene.

<span class="mw-page-title-main">ARFIP1</span> Protein-coding gene in the species Homo sapiens

Arfaptin-1 is a protein that in humans is encoded by the ARFIP1 gene.

<span class="mw-page-title-main">CCDC28B</span> Protein found in humans

Coiled-coil domain-containing protein 28B is a protein that in humans is encoded by the CCDC28B gene.

<span class="mw-page-title-main">IQSEC1</span> Protein-coding gene in the species Homo sapiens

IQ motif and SEC7 domain-containing protein 1 also known as ARF-GEP100 (ADP-Ribosylation Factor - Guanine nucleotide-Exchange Protein - 100-kDa) is a protein that in humans is encoded by the IQSEC1 gene.

<span class="mw-page-title-main">TTC8</span> Protein-coding gene in the species Homo sapiens

Tetratricopeptide repeat domain 8 (TTC8) also known as Bardet–Biedl syndrome 8 is a protein that in humans is encoded by the TTC8 gene.

<span class="mw-page-title-main">BBS7</span> Protein-coding gene in the species Homo sapiens

Bardet–Biedl syndrome 7 is a protein that in humans is encoded by the BBS7 gene.

<span class="mw-page-title-main">BBS9</span> Gene of the species Homo sapiens

Bardet–Biedl syndrome 9 is a protein that in humans is encoded by the BBS9 gene.

<span class="mw-page-title-main">BBS10</span> Gene

Bardet–Biedl syndrome 10, also known as BBS10 is a human gene.

<span class="mw-page-title-main">ARL13B</span> Protein-coding gene in the species Homo sapiens

ADP-ribosylation factor-like protein 13B (ARL13B), also known as ADP-ribosylation factor-like protein 2-like 1, is a protein that in humans is encoded by the ARL13B gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000113966 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022722 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Chiang AP, Nishimura D, Searby C, Elbedour K, Carmi R, Ferguson AL, Secrist J, Braun T, Casavant T, Stone EM, Sheffield VC (Jul 2004). "Comparative genomic analysis identifies an ADP-ribosylation factor-like gene as the cause of Bardet-Biedl syndrome (BBS3)". Am J Hum Genet. 75 (3): 475–84. doi:10.1086/423903. PMC   1182025 . PMID   15258860.
  6. Fan Y, Esmail MA, Ansley SJ, Blacque OE, Boroevich K, Ross AJ, Moore SJ, Badano JL, May-Simera H, Compton DS, Green JS, Lewis RA, van Haelst MM, Parfrey PS, Baillie DL, Beales PL, Katsanis N, Davidson WS, Leroux MR (Sep 2004). "Mutations in a member of the Ras superfamily of small GTP-binding proteins causes Bardet-Biedl syndrome". Nat Genet. 36 (9): 989–93. doi: 10.1038/ng1414 . PMID   15314642.
  7. 1 2 "Entrez Gene: ARL6 ADP-ribosylation factor-like 6".

Further reading