ADP-ribosylation factor 6 (ARF6) is a member of the ADP ribosylation factor family of GTP-binding proteins. ARF6 has a variety of cellular functions that are frequently involved in trafficking of biological membranes and transmembrane protein cargo. ARF6 has specifically been implicated in endocytosis of plasma membrane proteins and also, to a lesser extent, plasma membrane protein recycling.
This gene encodes a member of the human ARF gene family, which is part of the Ras superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7. [5]
ARF6 has been shown to interact with:
ADP-ribosylation factor 1 is a protein that in humans is encoded by the ARF1 gene.
ADP-ribosylation factor-binding protein GGA1 is a protein that in humans is encoded by the GGA1 gene.
Cytohesin-2 is a protein that in humans is encoded by the CYTH2 gene.
Cytohesin-1 formerly known as Pleckstrin homology, Sec7 and coiled/coil domains 1 (PSCD1) is a protein that in humans is encoded by the CYTH1 gene.
ADP-ribosylation factor 3 is a protein that in humans is encoded by the ARF3 gene.
Brefeldin A-inhibited guanine nucleotide-exchange protein 2 is a protein that in humans is encoded by the ARFGEF2 gene.
Golgin subfamily A member 4 is a protein that in humans is encoded by the GOLGA4 gene.
ADP-ribosylation factor 5 is a protein that in humans is encoded by the ARF5 gene.
ADP-ribosylation factor-like protein 4A is a protein that in humans is encoded by the ARL4A gene.
ADP-ribosylation factor 4 is a protein that in humans is encoded by the ARF4 gene.
ADP-ribosylation factor-like protein 3 is a protein that in humans is encoded by the ARL3 gene.
ADP-ribosylation factor-like protein 1 is a protein that in humans is encoded by the ARL1 gene.
ADP-ribosylation factor-like protein 2 is a protein that in humans is encoded by the ARL2 gene.
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the ASAP2 gene.
ADP-ribosylation factor-related protein 1 is a protein that in humans is encoded by the ARFRP1 gene.
GTP-binding protein ARD-1 is a protein that in humans is encoded by the TRIM23 gene.
Cytohesin-3 is a protein that in humans is encoded by the CYTH3 gene.
Arfaptin-2 is a protein that in humans is encoded by the ARFIP2 gene.
Arfaptin-1 is a protein that in humans is encoded by the ARFIP1 gene.
Cytohesin-4 is a protein that in humans is encoded by the CYTH4 gene.