Caulimovirus

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Caulimovirus
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TEM micrograph of CaMV virions
bar scale equals 100 nm
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(unranked): Virus
Realm: Riboviria
Kingdom: Pararnavirae
Phylum: Artverviricota
Class: Revtraviricetes
Order: Ortervirales
Family: Caulimoviridae
Genus:Caulimovirus

Caulimovirus is a genus of viruses, in the family Caulimoviridae order Ortervirales . They are para-retroviruses with dsDNA and plants as their host. There are 12 species in this genus. Diseases associated with this genus include: vein-clearing or banding mosaic. [1] [2]

Taxonomy

The genus contains the following species: [2]

Structure

Viruses in Caulimovirus are non-enveloped, with icosahedral geometries, and T=7, T=7 symmetry. The diameter is around 50 nm. Genomes are circular and non-segmented. The genome codes for 6 to 7 proteins. [1]

GenusStructureSymmetryCapsidGenomic arrangementGenomic segmentation
CaulimovirusIcosahedralT=7Non-envelopedCircularMonopartite

Life cycle

Caulimovirus Life Cycle.png

Caulimoviruses achieve entry into plant cells via damaged tissues, transmission via an animal vector (aphid insects) and seeds passed down to generations. Plant cells do not possess receptors like animal cells that would allow the virus to enter and since plant cells are thick, viruses achieve entry as aforementioned. Once inside the plant, the virus spreads using plasmodesmata, a membrane channel found in plants connecting one plant cell to another. Caulimoviruses are para-retroviruses with a DNA genome; thus, part of their viral replication takes place in the nucleus, where the host replication machinery is utilized. The rest of its life cycle takes place in the cytoplasm. Replication follows, where initially the dsDNA enters the nucleus and is transcribed into RNA using the host RNA polymerase. Then, the RNA is reverse transcribed to viral DNA using the host reverse transcriptase [3] in the cytoplasm. The viral product is made and assembled in the cytoplasm, which then spreads to other parts of the plant cell using plasmodesmata. Translation takes place by ribosomal shunting. For most Caulimoviruses, their genome is not integrated into the host cell; however, some viruses, such as Dahlia mosaic virus (genus Caulimovirus), have been identified as having integrated their genome into the host. Transmission routes are mechanical. [1]

GenusHost detailsTissue tropismEntry detailsRelease detailsReplication siteAssembly siteTransmission
CaulimovirusPlantsNoneViral movement; mechanical inoculationViral movementNucleusCytoplasmMechanical inoculation: aphids

Application: Plant Biotechnology

The Caulimovirus mosaic 35S promoter [4] has become a valuable tool for fine-tuning gene expression in plants and altering the phenotypes of transgenic plants. It can be used as modular cassette to control gene activity. Moreover, Caulimoviruses have also been investigated as possible vectors for introducing foreign genes into plants since these viruses have dsDNA. Since Caulimoviruses have regulatory promoter [5] elements, they play a role in developing plant modifications to increase resistance to disease and infections.

Related Research Articles

A provirus is a virus genome that is integrated into the DNA of a host cell. In the case of bacterial viruses (bacteriophages), proviruses are often referred to as prophages. However, proviruses are distinctly different from prophages and these terms should not be used interchangeably. Unlike prophages, proviruses do not excise themselves from the host genome when the host cell is stressed.

<span class="mw-page-title-main">Retrovirus</span> Family of viruses

A retrovirus is a type of virus that inserts a DNA copy of its RNA genome into the DNA of a host cell that it invades, thus changing the genome of that cell. After invading a host cell's cytoplasm, the virus uses its own reverse transcriptase enzyme to produce DNA from its RNA genome, the reverse of the usual pattern, thus retro (backwards). The new DNA is then incorporated into the host cell genome by an integrase enzyme, at which point the retroviral DNA is referred to as a provirus. The host cell then treats the viral DNA as part of its own genome, transcribing and translating the viral genes along with the cell's own genes, producing the proteins required to assemble new copies of the virus. Many retroviruses cause serious diseases in humans, other mammals, and birds.

Virus classification is the process of naming viruses and placing them into a taxonomic system similar to the classification systems used for cellular organisms.

<i>Hepadnaviridae</i> Family of viruses

Hepadnaviridae is a family of viruses. Humans, apes, and birds serve as natural hosts. There are currently 18 species in this family, divided among 5 genera. Its best-known member is hepatitis B virus. Diseases associated with this family include: liver infections, such as hepatitis, hepatocellular carcinomas, and cirrhosis. It is the sole accepted family in the order Blubervirales.

Cauliflower mosaic virus (CaMV) is a member of the genus Caulimovirus, one of the six genera in the family Caulimoviridae, which are pararetroviruses that infect plants. Pararetroviruses replicate through reverse transcription just like retroviruses, but the viral particles contain DNA instead of RNA.

<i>Geminiviridae</i> Family of viruses

Geminiviridae is a family of plant viruses that encode their genetic information on a circular genome of single-stranded (ss) DNA. There are 520 species in this family, assigned to 14 genera. Diseases associated with this family include: bright yellow mosaic, yellow mosaic, yellow mottle, leaf curling, stunting, streaks, reduced yields. They have single-stranded circular DNA genomes encoding genes that diverge in both directions from a virion strand origin of replication. According to the Baltimore classification they are considered class II viruses. It is the largest known family of single stranded DNA viruses.

Metaviridae is a family of viruses which exist as Ty3-gypsy LTR retrotransposons in a eukaryotic host's genome. They are closely related to retroviruses: members of the family Metaviridae share many genomic elements with retroviruses, including length, organization, and genes themselves. This includes genes that encode reverse transcriptase, integrase, and capsid proteins. The reverse transcriptase and integrase proteins are needed for the retrotransposon activity of the virus. In some cases, virus-like particles can be formed from capsid proteins.

Pseudoviridae is a family of viruses, which includes three genera.

Caulimoviridae is a family of viruses infecting plants. There are 94 species in this family, assigned to 11 genera. Viruses belonging to the family Caulimoviridae are termed double-stranded DNA (dsDNA) reverse-transcribing viruses i.e. viruses that contain a reverse transcription stage in their replication cycle. This family contains all plant viruses with a dsDNA genome that have a reverse transcribing phase in their lifecycle.

<span class="mw-page-title-main">Viral replication</span> Formation of biological viruses during the infection process

Viral replication is the formation of biological viruses during the infection process in the target host cells. Viruses must first get into the cell before viral replication can occur. Through the generation of abundant copies of its genome and packaging these copies, the virus continues infecting new hosts. Replication between viruses is greatly varied and depends on the type of genes involved in them. Most DNA viruses assemble in the nucleus while most RNA viruses develop solely in cytoplasm.

<i>Tobamovirus</i> Genus of viruses

Tobamovirus is a genus of positive-strand RNA viruses in the family Virgaviridae. Many plants, including tobacco, potato, tomato, and squash, serve as natural hosts. Diseases associated with this genus include: necrotic lesions on leaves. The name Tobamovirus comes from the host and symptoms of the first virus discovered.

<i>Gammaretrovirus</i> Genus of viruses

Gammaretrovirus is a genus in the Retroviridae family. Example species are the murine leukemia virus and the feline leukemia virus. They cause various sarcomas, leukemias and immune deficiencies in mammals, reptiles and birds.

Baltimore classification is a system used to classify viruses based on their manner of messenger RNA (mRNA) synthesis. By organizing viruses based on their manner of mRNA production, it is possible to study viruses that behave similarly as a distinct group. Seven Baltimore groups are described that take into consideration whether the viral genome is made of deoxyribonucleic acid (DNA) or ribonucleic acid (RNA), whether the genome is single- or double-stranded, and whether the sense of a single-stranded RNA genome is positive or negative.

<i>Potyvirus</i> Genus of positive-strand RNA viruses in the family Potyviridae

Potyvirus is a genus of positive-strand RNA viruses in the family Potyviridae. Plants serve as natural hosts. Like begomoviruses, members of this genus may cause significant losses in agricultural, pastoral, horticultural, and ornamental crops. More than 200 species of aphids spread potyviruses, and most are from the subfamily Aphidinae. The genus contains 190 species and potyviruses account for about thirty percent of all currently known plant viruses.

The murine leukemia viruses are retroviruses named for their ability to cause cancer in murine (mouse) hosts. Some MLVs may infect other vertebrates. MLVs include both exogenous and endogenous viruses. Replicating MLVs have a positive sense, single-stranded RNA (ssRNA) genome that replicates through a DNA intermediate via the process of reverse transcription.

<i>Cowpea chlorotic mottle virus</i> Species of virus

Cowpea chlorotic mottle virus, known by the abbreviation CCMV, is a virus that specifically infects the cowpea plant, or black-eyed pea. The leaves of infected plants develop yellow spots, hence the name "chlorotic". Similar to its "brother" virus, Cowpea mosaic virus (CPMV), CCMV is produced in high yield in plants. In the natural host, viral particles can be produced at 1–2 mg per gram of infected leaf tissue. Belonging to the bromovirus genus, cowpea chlorotic mottle virus (CCMV) is a small spherical plant virus. Other members of this genus include the brome mosaic virus (BMV) and the broad bean mottle virus (BBMV).

Mason-Pfizer monkey virus (M-PMV), formerly Simian retrovirus (SRV), is a species of retroviruses that usually infect and cause a fatal immune deficiency in Asian macaques. The ssRNA virus appears sporadically in mammary carcinoma of captive macaques at breeding facilities which expected as the natural host, but the prevalence of this virus in feral macaques remains unknown. M-PMV was transmitted naturally by virus-containing body fluids, via biting, scratching, grooming, and fighting. Cross contaminated instruments or equipment (fomite) can also spread this virus among animals.

<i>Badnavirus</i> Genus of viruses

Badnavirus is a genus of viruses, in the family Caulimoviridae order Ortervirales. Plants serve as natural hosts. There are 67 species in this genus. Diseases associated with this genus include: CSSV: leaf chlorosis, root necrosis, red vein banding in young leaves, small mottled pods, and stem/root swelling followed by die-back. Infection decreases yield by 25% within one year, 50% within two years and usually kills trees within 3–4 years.

<i>Ortervirales</i> Order of viruses

Ortervirales is an order that contains all accepted species of single-stranded RNA viruses that replicate through a DNA intermediate and all accepted species of double-stranded DNA viruses that replicate through an RNA intermediate . The name is derived from the reverse of retro.

<i>Riboviria</i> Realm of viruses

Riboviria is a realm of viruses that includes all viruses that use a homologous RNA-dependent polymerase for replication. It includes RNA viruses that encode an RNA-dependent RNA polymerase, as well as reverse-transcribing viruses that encode an RNA-dependent DNA polymerase. RNA-dependent RNA polymerase (RdRp), also called RNA replicase, produces RNA from RNA. RNA-dependent DNA polymerase (RdDp), also called reverse transcriptase (RT), produces DNA from RNA. These enzymes are essential for replicating the viral genome and transcribing viral genes into messenger RNA (mRNA) for translation of viral proteins.

References

  1. 1 2 3 "Viral Zone". ExPASy. Retrieved 15 June 2015.
  2. 1 2 "Virus Taxonomy: 2020 Release". International Committee on Taxonomy of Viruses (ICTV). March 2021. Retrieved 21 May 2021.
  3. "Reverse transcriptase | Enzyme Function & Applications | Britannica". www.britannica.com. 13 March 2024. Retrieved 10 April 2024.
  4. Bak, Aurélie; Emerson, Joanne B. (2020). "Cauliflower mosaic virus (CaMV) Biology, Management, and Relevance to GM Plant Detection for Sustainable Organic Agriculture". Frontiers in Sustainable Food Systems. 4. doi: 10.3389/fsufs.2020.00021 . ISSN   2571-581X.
  5. Nasim, Noohi; Dey, Nrisingha (1 March 2022). "Pararetroviruses: Plant Infecting dsDNA Viruses". Plant Molecular Biology Reporter. 40 (1): 106–118. doi:10.1007/s11105-021-01294-7. ISSN   1572-9818.