FUT1

FUT1
Identifiers
Aliases	FUT1 , HH, HSC, fucosyltransferase 1 (H blood group), H
External IDs	OMIM: 211100 MGI: 109375 HomoloGene: 120 GeneCards: FUT1
Gene location (Human)
Chr.	Chromosome 19 (human)
End	48,755,390 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	45,621,059 bp
RNA expression pattern
	Top expressed in
	vagina; ; Body of pancreas; ; pancreas; ; fundus; ; right lung; ; stomach; ; upper lobe of left lung; ; ovary; ; body of stomach; ; squamous epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity ; galactoside 2-alpha-L-fucosyltransferase activity ; fucosyltransferase activity ; glycosyltransferase activity ;
Cellular component	integral component of membrane ; Golgi cisterna membrane ; Golgi apparatus ; integral component of plasma membrane ; membrane ;
Biological process	protein glycosylation ; L-fucose catabolic process ; fucosylation ; carbohydrate metabolic process ;
	Sources:Amigo / QuickGO
Orthologs
	2523
	14343
	ENSG00000174951
	ENSMUSG00000008461
	P19526
	O09160
	NM_000148 ; NM_001329877 ; NM_001384359
	NM_001271981 ; NM_008051
	NP_000139 ; NP_001316806
	NP_001258910 ; NP_032077
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 06, 2021

Galactoside 2-alpha-L-fucosyltransferase 1 is an enzyme that in humans is encoded by the FUT1 gene.^[5]

The enzyme is involved in the synthesis of the H antigen.

Related Research Articles

A fucosyltransferase is an enzyme that transfers an L-fucose sugar from a GDP-fucose donor substrate to an acceptor substrate. The acceptor substrate can be another sugar such as the transfer of a fucose to a core GlcNAc (N-acetylglucosamine) sugar as in the case of N-linked glycosylation, or to a protein, as in the case of O-linked glycosylation produced by O-fucosyltransferase. There are various fucosyltransferases in mammals, the vast majority of which, are located in the Golgi apparatus. The O-fucosyltransferases have recently been shown to localize to the endoplasmic reticulum (ER).

hh, or the Bombay blood group, is a rare blood type. This blood phenotype was first discovered in Bombay by Dr. Y. M. Bhende in 1952. It is mostly found in the Indian sub-continent and parts of the Middle East such as Iran.

The Lewis antigen system is a human blood group system. It is based upon two genes on chromosome 19: FUT3, or Lewis gene; and FUT2, or Secretor gene. Both genes are expressed in glandular epithelia. FUT2 has a dominant allele which codes for an enzyme and a recessive allele which does not produce a functional enzyme. Similarly, FUT3 has a functional dominant allele (Le) and a non-functional recessive allele (le).

Beta-galactoside alpha-2,6-sialyltransferase 1 is an enzyme that in humans is encoded by the ST6GAL1 gene.

Endothelial PAS domain-containing protein 1 is a protein that is encoded by the EPAS1 gene in mammals. It is a type of hypoxia-inducible factor, a group of transcription factors involved in the physiological response to oxygen concentration. The gene is active under hypoxic conditions. It is also important in the development of the heart, and for maintaining the catecholamine balance required for protection of the heart. Mutation often leads to neuroendocrine tumors.

In enzymology, a 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a galactoside 2-alpha-L-fucosyltransferase is an enzyme that catalyzes the chemical reaction

Galactoside 3(4)-L-fucosyltransferase is an enzyme that in humans is encoded by the FUT3 gene.

Galactoside 2-alpha-L-fucosyltransferase 2 is an enzyme that in humans is encoded by the FUT2 gene. It affects the secretor status of ABO antigens.

Alpha-(1,3)-fucosyltransferase is an enzyme that in humans is encoded by the FUT7 gene.

Alpha-(1,3)-fucosyltransferase is an enzyme that in humans is encoded by the FUT6 gene.

Alpha-(1,6)-fucosyltransferase is an enzyme that in humans is encoded by the FUT8 gene.

Galectin-2 is a protein that in humans is encoded by the LGALS2 gene.

Alpha-(1,3)-fucosyltransferase is an enzyme that in humans is encoded by the FUT9 gene.

CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase is an enzyme that in humans is encoded by the ST3GAL4 gene.

Lactosylceramide 4-alpha-galactosyltransferase is an enzyme that in humans is encoded by the A4GALT gene.

Alpha-(1,3)-fucosyltransferase is an enzyme that in humans is encoded by the FUT5 gene.

Hemoglobin, alpha 2 also known as HBA2 is a gene that in humans codes for the alpha globin chain of hemoglobin.

Fucosyltransferase 4 , also known as FUT4, is an enzyme which in humans is encoded by the FUT4 gene.

Fucosyltransferase 4 is a protein that in humans is encoded by the FUT4 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000174951 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000008461 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)".

Ball SP, Tongue N, Gibaud A, Le Pendu J, Mollicone R, Gérard G, Oriol R (July 1991). "The human chromosome 19 linkage group FUT1 (H), FUT2 (SE), LE, LU, PEPD, C3, APOC2, D19S7 and D19S9". Annals of Human Genetics. 55 (Pt 3): 225–33. doi:10.1111/j.1469-1809.1991.tb00417.x. PMID 1763885. S2CID 30777695.
Larsen RD, Ernst LK, Nair RP, Lowe JB (September 1990). "Molecular cloning, sequence, and expression of a human GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase cDNA that can form the H blood group antigen". Proceedings of the National Academy of Sciences of the United States of America. 87 (17): 6674–8. Bibcode:1990PNAS...87.6674L. doi: 10.1073/pnas.87.17.6674 . PMC 54599 . PMID 2118655.
Reguigne-Arnould I, Couillin P, Mollicone R, Fauré S, Fletcher A, Kelly RJ, Lowe JB, Oriol R (1995). "Relative positions of two clusters of human alpha-L-fucosyltransferases in 19q (FUT1-FUT2) and 19p (FUT6-FUT3-FUT5) within the microsatellite genetic map of chromosome 19". Cytogenetics and Cell Genetics. 71 (2): 158–62. doi:10.1159/000134098. PMID 7656588.
Bruneau N, Lombardo D (June 1995). "Chaperone function of a Grp 94-related protein for folding and transport of the pancreatic bile salt-dependent lipase". The Journal of Biological Chemistry. 270 (22): 13524–33. doi: 10.1074/jbc.270.22.13524 . PMID 7768954.
Kelly RJ, Ernst LK, Larsen RD, Bryant JG, Robinson JS, Lowe JB (June 1994). "Molecular basis for H blood group deficiency in Bombay (Oh) and para-Bombay individuals". Proceedings of the National Academy of Sciences of the United States of America. 91 (13): 5843–7. Bibcode:1994PNAS...91.5843K. doi: 10.1073/pnas.91.13.5843 . PMC 44093 . PMID 7912436.
Koda Y, Soejima M, Kimura H (March 1997). "Structure and expression of H-type GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase gene (FUT1). Two transcription start sites and alternative splicing generate several forms of FUT1 mRNA". The Journal of Biological Chemistry. 272 (11): 7501–5. doi: 10.1074/jbc.272.11.7501 . PMID 9054453.
Wagner FF, Flegel WA (March 1997). "Polymorphism of the h allele and the population frequency of sporadic nonfunctional alleles". Transfusion. 37 (3): 284–90. doi:10.1046/j.1537-2995.1997.37397240210.x. PMID 9122901. S2CID 25273202.
Kaneko M, Nishihara S, Shinya N, Kudo T, Iwasaki H, Seno T, Okubo Y, Narimatsu H (July 1997). "Wide variety of point mutations in the H gene of Bombay and para-Bombay individuals that inactivate H enzyme". Blood. 90 (2): 839–49. doi: 10.1182/blood.V90.2.839 . PMID 9226185.
Koda Y, Soejima M, Johnson PH, Smart E, Kimura H (September 1997). "Missense mutation of FUT1 and deletion of FUT2 are responsible for Indian Bombay phenotype of ABO blood group system". Biochemical and Biophysical Research Communications. 238 (1): 21–5. doi:10.1006/bbrc.1997.7232. PMID 9299444.
Koda Y, Soejima M, Kimura H (September 1998). "Changing transcription start sites in H-type alpha(1,2)fucosyltransferase gene (FUT1) during differentiation of the human erythroid lineage". European Journal of Biochemistry. 256 (2): 379–87. doi:10.1046/j.1432-1327.1998.2560379.x. PMID 9760178.
Roos C, Kolmer M, Mattila P, Renkonen R (February 2002). "Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism". The Journal of Biological Chemistry. 277 (5): 3168–75. doi: 10.1074/jbc.M107927200 . PMID 11698403.
Yip SP, Chee KY, Chan PY, Chow EY, Wong HF (October 2002). "Molecular genetic analysis of para-Bombay phenotypes in Chinese: a novel non-functional FUT1 allele is identified". Vox Sanguinis. 83 (3): 258–62. doi:10.1046/j.1423-0410.2002.00184.x. hdl: 10397/32501 . PMID 12366770. S2CID 37005881.
López-Ferrer A, de Bolós C (January 2002). "The expression of human FUT1 in HT-29/M3 colon cancer cells instructs the glycosylation of MUC1 and MUC5AC apomucins". Glycoconjugate Journal. 19 (1): 13–21. doi:10.1023/A:1022576712961. PMID 12652076. S2CID 13065601.
Shi S, Stanley P (April 2003). "Protein O-fucosyltransferase 1 is an essential component of Notch signaling pathways". Proceedings of the National Academy of Sciences of the United States of America. 100 (9): 5234–9. Bibcode:2003PNAS..100.5234S. doi: 10.1073/pnas.0831126100 . PMC 154328 . PMID 12697902.
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Guo ZH, Xiang D, Zhu ZY, Wang JL, Zhang JM, Liu X, Shen W, Chen HP (October 2004). "[Analysis on FUT1 and FUT2 gene of 10 para-Bombay individuals in China]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics. 21 (5): 417–21. PMID 15476160.
Yan L, Zhu F, Xu X, Hong X, Lv Q (May 2005). "Molecular basis for para-Bombay phenotypes in Chinese persons, including a novel nonfunctional FUT1 allele". Transfusion. 45 (5): 725–30. doi:10.1111/j.1537-2995.2005.04305.x. PMID 15847661. S2CID 21841537.
Mejías-Luque R, López-Ferrer A, Garrido M, Fabra A, de Bolós C (July 2007). "Changes in the invasive and metastatic capacities of HT-29/M3 cells induced by the expression of fucosyltransferase 1". Cancer Science. 98 (7): 1000–5. doi:10.1111/j.1349-7006.2007.00484.x. PMID 17459061. S2CID 24079329.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000174951 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000008461 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)".

[1]

[2]

[3]

[4]

[5]

FUT1

Related Research Articles

References

Further reading