TSPAN13

TSPAN13
Identifiers
Aliases	TSPAN13 , NET-6, NET6, TM4SF13, tetraspanin 13
External IDs	OMIM: 613139 MGI: 1913359 HomoloGene: 8671 GeneCards: TSPAN13
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7p21.1 Start 16,753,755 bp [1] End 16,784,536 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12|12 A3 Start 36,064,556 bp [2] End 36,092,499 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland visceral pleura jejunal mucosa endothelial cell Brodmann area 23 lower lobe of lung germinal epithelium bronchial epithelial cell middle temporal gyrus pancreatic epithelial cell Top expressed in habenula lacrimal gland subiculum utricle crypt of lieberkuhn of small intestine salivary gland parotid gland olfactory tubercle right lung right lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium channel regulator activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process cell surface receptor signaling pathway regulation of calcium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27075 66109 Ensembl ENSG00000106537 ENSMUSG00000020577 UniProt O95857 Q9D8C2 RefSeq (mRNA) NM_014399 NM_025359 RefSeq (protein) NP_055214 NP_079635 Location (UCSC) Chr 7: 16.75 – 16.78 Mb Chr 12: 36.06 – 36.09 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Tetraspanin-13 is a protein that in humans is encoded by the TSPAN13 gene. ^[5]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000106537 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020577 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: TSPAN13 tetraspanin 13".

Further reading

• Böhme E, Graf H, Schultz G (1978). "Effects of sodium nitroprusside and other smooth muscle relaxants on cyclic GMP formation in smooth muscle and platelets". Advances in Cyclic Nucleotide Research. 9: 131–43. PMID   27075.
• Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye". J. Cell Sci. 114 (Pt 23): 4143–51. doi:10.1242/jcs.114.23.4143. PMID   11739647.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Serru V, Dessen P, Boucheix C, Rubinstein E (2000). "Sequence and expression of seven new tetraspans". Biochim. Biophys. Acta. 1478 (1): 159–63. doi:10.1016/S0167-4838(00)00022-4. PMID   10719184.
• Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi: 10.1073/pnas.160270997 . PMC   16901 . PMID   10931946.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC   2882961 . PMID   12690205.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Huang H, Groth J, Sossey-Alaoui K, et al. (2005). "Aberrant expression of novel and previously described cell membrane markers in human breast cancer cell lines and tumors". Clin. Cancer Res. 11 (12): 4357–64. doi: 10.1158/1078-0432.CCR-04-2107 . PMID   15958618.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.
• Moroz MA, Serganova I, Zanzonico P, et al. (2007). "Imaging hNET reporter gene expression with 124I-MIBG". J. Nucl. Med. 48 (5): 827–36. doi: 10.2967/jnumed.106.037812 . PMID   17475971.