Roger Federer defeated Lleyton Hewitt in the final, 6–0, 7–6(7–3), 6–0 to win the men's singles tennis title at the 2004 US Open. It was his first US Open title and his fourth Major title overall. With the win, he became the tenth man to win three Majors in a calendar year.
José Acasuso was the defending champion, but chose not to participate this year.
Spain's Rafael Nadal defeated Chile's Fernando González in the final, 6–3, 7–6(7–2), 6–3 to win the gold medal in Men's Singles tennis at the 2008 Summer Olympics. The win gave him the third of five components of the career Golden Slam, having already won the French Open and Wimbledon. He would go on to win the Australian Open and the U.S. Open to become the second man to complete the career Golden Slam in singles. Following the event, Nadal became the world No. 1 for the first time, ending Roger Federer's record streak of 237 consecutive weeks with the top ranking. González became the first man to win a medal in men's singles across consecutive Olympiads since Charles Winslow in 1920. In the bronze medal match, Serbia's Novak Djokovic defeated the United States' James Blake, 6–3, 7–6(7–4). It was Serbia's first Olympic tennis medal.
Nicolás Massú was the defending champion but lost in the first round to Agustín Calleri.
Gastón Gaudio was the defending champion, but lost in the second round this year.
Four-time defending champion Rafael Nadal successfully defended his title, defeating David Ferrer in a rematch of the previous year's final, 6–2, 7–5, to win the singles title at the 2009 Barcelona Open. It was his record-extending fifth title at the Barcelona Open.
Rafael Nadal defeated the defending champion Novak Djokovic in the final, 7–6(7–2), 6–2 to win the men's singles title at the 2009 Italian Open. It was his record fourth Italian Open title.
Nicolás Almagro was the defending champion; however, he lost 1–6, 7–5, 2–6 to Juan Carlos Ferrero in the quarterfinals.
David Ferrer won in the final 6–3, 3–6, 6–1 against Juan Carlos Ferrero.
Andy Murray was the defending champion, but lost to Mardy Fish in the second round.
James Blake was the defending champion but lost in the quarterfinals to Andre Agassi.
David Sánchez was the defending champion but lost in the semifinals to Gustavo Kuerten.
Fernando González was the defending champion, but did not participate this year.
Nicolás Massú was the defending champion, but lost in the semifinals this year.
Jaroslav Levinský and David Škoch were the defending champions, but Levinský did not participate this year. Škoch partnered Jiří Vaněk, losing in the semifinals.
Mark Knowles and Daniel Nestor were the defending champions, but lost in the first round to Paul Goldstein and Jim Thomas.
Bob Bryan and Mike Bryan were the defending champions, but lost in the semifinals to Leander Paes and Radek Štěpánek. The loss ended the Bryan brothers' bid to win a calendar grand slam.
In the 2005 Austrian Open Singles, Nicolás Massú was the defending champion, but lost in the semifinals to Fernando Verdasco.
Mariano Zabaleta was the defending champion, and defended his title defeating Gastón Gaudio 6–1, 4–6, 7–6(7–4) in the final.
Wesley Whitehouse defeated Daniel Elsner in the final, 6–3, 7–6(8–6) to win the boys' singles tennis title at the 1997 Wimbledon Championships.
Guillermo Coria was the defending champion, but did not compete this year.
Fernando González 
Jean-René Lisnard 
