Virginia Ruano Pascual and Paola Suárez were the defending champions, but lost in the second round to Jelena Dokić and Corina Morariu.
Kimberly Po-Messerli and Nicole Pratt were the defending champions. They were both present but did not compete together.
Po-Messerli partnered with Corina Morariu, but lost in the quarterfinals to Virginia Ruano Pascual and Paola Suárez.
Pratt partnered with Alicia Molik, but withdrew before their second round match against Elena Dementieva and Janette Husárová.
This article refers to the sport of tennis.
The 1999 ANZ Tasmanian International doubles was the doubles event of the sixth edition of the ANZ Tasmanian International. Virginia Ruano Pascual and Paola Suárez were the defending champions but only Ruano Pascual competed that year with Florencia Labat. Labat and Ruano Pascual lost in the first round to Nannie de Villiers and Eva Melicharová.
The 1999 WTA Madrid Open doubles was the doubles event of the fourth edition of the Internationaux de Strasbourg, a WTA Tier III tournament held in Madrid, Spain and part of the European clay court season. Florencia Labat and Dominique Van Roost were the defending champions, but they did not compete this year.
Virginia Ruano Pascual and Paola Suárez were the defending champions and won in the final 6–2, 6–3, against Svetlana Kuznetsova and Martina Navratilova in straight sets. This was Ruano Pascual's 4th career Grand Slam doubles title and her 2nd title at the US Open. It was also Suárez' 4th career Grand Slam doubles title and her 2nd title at the US Open.
Elena Dementieva and Flavia Pennetta were the defending champions, but lost in second round to Virginia Ruano Pascual and Paola Suárez.
Lisa Raymond and Rennae Stubbs were the defending champions, but lost in third round to Kim Clijsters and Meghann Shaughnessy.
Lisa Raymond and Rennae Stubbs were the defending champions and successfully defended their title, defeating Alexandra Fusai and Caroline Vis 6–4, 3–6, 7–6(7–4) in the final. It was the 33rd title for Raymond and the 37th title for Stubbs in their respective careers. It was also the 6th title for the pair in the year.
Lisa Raymond and Rennae Stubbs were the defending champions, but Raymond did not compete in this edition. Stubbs teamed up with Elena Bovina and lost in quarterfinals to Virginia Ruano Pascual and Paola Suárez.
Virginia Ruano Pascual and Paola Suárez were the defending champions, but lost in quarterfinals to Els Callens and Émilie Loit.
Svetlana Kuznetsova and Martina Navratilova were the defending champions, but Kuznetsova decided not to compete this year. Navratilova teamed up with Lisa Raymond and lost in second round to Elena Likhovtseva and Anastasia Myskina.
Elena Dementieva and Janette Husárová were the defending champions, but had different outcomes. Dementieva had to withdraw due to a left foot strain, while Husárová teamed up with Elena Likhovtseva and reached the semifinals.
Virginia Ruano Pascual and Paola Suárez were the defending champions, but lost in semifinals to Nadia Petrova and Meghann Shaughnessy. The latter pair eventually won the title, by defeating Janette Husárová and Conchita Martínez 6–2, 2–6, 6–1 in the final.
Virginia Ruano Pascual and Paola Suárez were the defending champions and successfully defended their title, by defeating Martina Navratilova and Lisa Raymond 6–4, 6–1 in the final.
Virginia Ruano Pascual and Paola Suárez were the defending champions, but had different outcomes. While Suárez did not compete this year, Ruano Pascual teamed up with Conchita Martínez and successfully defended her title, by defeating Iveta Benešová and Květa Peschke 6–1, 6–4 in the final.
Cara Black and Elena Likhovtseva were the defending champions, but lost in semifinals to Conchita Martínez and Patricia Tarabini.
Chan Yung-jan and Chuang Chia-jung were the defending champions, but Chan did not compete this year. Chuang teamed up with Mariana Díaz Oliva and lost in the final to Virginia Ruano Pascual and Paola Suárez, 6–2, 6–3.
Janette Husárová and Conchita Martínez were the defending champions, but Husárová did not compete this year. Martínez teamed up with Elena Likhovtseva and lost in quarterfinals to Daniela Hantuchová and Francesca Schiavone.
Nuria Llagostera Vives and María Vento-Kabchi were the defending champions, but Llagostera Vives did not compete this year. Vento-Kabchi teamed up with Lourdes Domínguez Lino and lost in first round to Séverine Brémond and Amélie Mauresmo.
Virginia Ruano Pascual 
Paola Suárez 
Émilie Loit 
Rossana de los Ríos 
