| Women's singles | |
|---|---|
| 2005 Pilot Pen Tennis | |
| Champion |  Lindsay Davenport |
| Runner-up |  Amélie Mauresmo |
| Final score | 6–4, 6–4 |
| Draw | 28 |
| Seeds | 8 |
Elena Bovina was the defending champion, but did not compete this year due to a right shoulder injury.
Lindsay Davenport won the title, defeating Amélie Mauresmo 6–4, 6–4 in the final.
The first four seeds received a bye into the second round.
Lindsay Davenport (champion) Amélie Mauresmo (final)
Elena Dementieva (quarterfinals) 
Patty Schnyder (second round)
Alicia Molik (first round) Nathalie Dechy (first round)
Jelena Janković (first round)| Semifinals | Final | ||||||||||||
| 1 | Lindsay Davenport | 6 | 6 | ||||||||||
| Anna Chakvetadze | 3 | 3 | |||||||||||
| 1 | Lindsay Davenport | 6 | 6 | ||||||||||
| 2 | Amélie Mauresmo | 4 | 4 | ||||||||||
 Anabel Medina Garrigues | 6 | 65 | 2 | ||||||||||
| 2 | Amélie Mauresmo | 4 | 77 | 6 | |||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | L Davenport | 6 | 6 | ||||||||||||||||||||||||
| T Golovin | 3 | 4 | Q |  K Peschke | 4 | 1 | |||||||||||||||||||||
| Q | K Peschke | 6 | 6 | 1 | L Davenport | 6 | 77 | ||||||||||||||||||||
| N Llagostera Vives | 4 | 2 |  D Hantuchová | 2 | 65 | ||||||||||||||||||||||
| D Hantuchová | 6 | 6 | D Hantuchová | 5 | 6 | 6 | |||||||||||||||||||||
| WC | L Raymond | 3 | 6 | 2 | 6 | P Schnyder | 7 | 2 | 4 | ||||||||||||||||||
| 6 | P Schnyder | 6 | 1 | 6 | 1 | L Davenport | 6 | 6 | |||||||||||||||||||
| A Chakvetadze | 3 | 3 | |||||||||||||||||||||||||
| LL |  J Zheng | 6 | 6 | ||||||||||||||||||||||||
 M Maleeva | 4 | 6 | 2 | Q | J Jackson | 3 | 4 | ||||||||||||||||||||
| Q | J Jackson | 6 | 0 | 6 | LL | J Zheng | 4 | 4 | |||||||||||||||||||
| LL | M Kirilenko | 6 | 6 | A Chakvetadze | 6 | 6 | |||||||||||||||||||||
 S Farina Elia | 1 | 3 | LL | M Kirilenko | 3 | 3 | |||||||||||||||||||||
| A Chakvetadze | 6 | 3 | 6 | A Chakvetadze | 6 | 6 | |||||||||||||||||||||
| 10 | J Janković | 3 | 6 | 2 | |||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| WC/7 | A Molik | 2 | 4 | ||||||||||||||||||||||||
 G Dulko | 6 | 6 | G Dulko | 0 | 712 | 4 | |||||||||||||||||||||
| A Medina Garrigues | 6 | 6 | A Medina Garrigues | 6 | 610 | 6 | |||||||||||||||||||||
| V Razzano | 4 | 2 | A Medina Garrigues | 6 | 6 | ||||||||||||||||||||||
| V Dushevina | 6 | 6 | 4 | E Dementieva | 4 | 3 | |||||||||||||||||||||
| Q | S Peng | 4 | 4 | V Dushevina | 2 | 4 | |||||||||||||||||||||
| 4 | E Dementieva | 6 | 6 | ||||||||||||||||||||||||
| A Medina Garrigues | 6 | 65 | 2 | ||||||||||||||||||||||||
| 9 | N Dechy | 63 | 6 | 4 | 2 | A Mauresmo | 4 | 77 | 6 | ||||||||||||||||||
| WC | M Shaughnessy | 77 | 2 | 6 | WC | M Shaughnessy | 3 | 5 | |||||||||||||||||||
| Q |  J Kostanić | 4 | 1 |  A-L Grönefeld | 6 | 7 | |||||||||||||||||||||
| A-L Grönefeld | 6 | 6 | A-L Grönefeld | 3 | 2 | ||||||||||||||||||||||
| M Bartoli | 6 | 67 | 3 | 2 | A Mauresmo | 6 | 6 | ||||||||||||||||||||
| E Likhovtseva | 4 | 79 | 6 | E Likhovtseva | 1 | 3 | |||||||||||||||||||||
| 2 | A Mauresmo | 6 | 6 | ||||||||||||||||||||||||
Maria Sharapova defeated Justine Henin-Hardenne in the final, 6–4, 6–4 to win the women's singles tennis title at the 2006 US Open. It was her second major title. She lost just one set during the tournament. By reaching the final, Henin-Hardenne became the eighth woman to reach all four major finals in a calendar year.
Serena Williams was the defending champion, but was forced to withdraw due to a left knee injury.
Amélie Mauresmo was the defending champion, but she withdrew due to illness.
Amélie Mauresmo was the defending champion but withdrew from her semifinal match against Lindsay Davenport.
Alicia Molik was the defending champion, but retired in the first round against Jelena Janković.
Lindsay Davenport was the defending champion, but was forced to retire in the final due to a right shoulder strain.
Justine Henin was the defending champion, but withdrew due to a virus.
Amélie Mauresmo was the defending champion and successfully defended her title, defeating Patty Schnyder 2–6, 6–3, 6–4 in the final.
Justine Henin-Hardenne was the defending champion, but did not compete this year due to a hypoglycemia.
Venus Williams was the defending champion, but lost in third round to Jelena Dokic.
Lindsay Davenport was the defending champion, but lost in the final to tournament winner Patty Schnyder 6–7(5–7), 7–6(10–8), 6–3.
Elena Dementieva was the defending champion, but lost in second round to Jelena Kostanić.
Kim Clijsters was the defending champion, but was forced to withdraw due to a left ankle injury.
Kim Clijsters was the two-time defending champion, but did not compete this year due to an injury on her left wrist.
Justine Henin-Hardenne was the defending champion, but did not compete this year.
Lindsay Davenport was the defending champion and successfully defended her title, by defeating Amélie Mauresmo 6–2, 6–4 in a rematch of the previous year's final.
Amélie Mauresmo was the two-time defending champion, and successfully defended her title.
Lindsay Davenport was the defending champion from when the event was last held in 2000, but she decided not to participate this year.
Lindsay Davenport defeated Venus Williams in the final, 6–4, 3–6, 6–2 to win the Singles title at the 2000 Generali Ladies Linz. With the win, Davenport ended Williams' 35-match winning streak, extending from the Wimbledon Championships earlier in the year. Williams' 35-match winning streak is, as of 2022, the longest since January 1, 2000.
Venus Williams was the two-time defending champion and successfully defended her title, by defeating Lindsay Davenport 7–6(8–6), 6–4 in the final.