2006 French Open mixed doubles was an event at the 2006 French Open.
Jonas Björkman and Max Mirnyi were the defending champions, but lost in the quarterfinals this year.
Arnaud Clément and Michaël Llodra were the defending champions, but lost in the semifinals to Daniel Nestor and Nenad Zimonjić.
Fabrice Santoro and Nenad Zimonjić were the defending champions. They were both present but did not compete together.
Santoro partnered with Richard Gasquet, but lost in the semifinals to Zimonjic and partner Daniel Nestor, who lost in the final.
Tim Henman and Nenad Zimonjić were the defending champions. They were both present but did not compete together.
Henman partnered with Yves Allegro and Zimonjić with Leander Paes.
Mahesh Bhupathi and Leander Paes were the defending champions. They were both present but did not compete together.
Bhupathi partnered with Martin Damm, but lost in the quarterfinals to Wayne Black and Kevin Ullyett.
Paes partnered with Nenad Zimonjić, but lost in the second round to Jonathan Erlich and Andy Ram.
Fabrice Santoro and Nenad Zimonjić were the defending champions, but Simon Aspelin and Julian Knowle defeated them 6–4, 7–6(7–5), in the final.
Yves Allegro and Roger Federer were the defending champions, but Federer chose not to participate, and only Allegro competed that year.
Allegro partnered with Marat Safin, but lost in the semifinals to Michael Kohlmann and Rainer Schüttler.
Jonas Björkman and Max Mirnyi defeated Mark Knowles and Daniel Nestor in the final, 6–2, 6–4 to win the doubles tennis title at the 2006 Tennis Masters Cup.
Michaël Llodra and Fabrice Santoro defeated Leander Paes and Nenad Zimonjić in the final, 6–7(6–8), 6–3, 7–6(7–4) to win the doubles tennis title at the 2005 Tennis Masters Cup.
Max Mirnyi and Mikhail Youzhny were the defending champions, but Mirnyi did not participate this year. Youzhny partnered Marat Safin, losing in the first round.
Bob Bryan and Mike Bryan were the defending champions, but lost in the semifinals this year.
Jonas Björkman and Max Mirnyi were the defending champions.
Mark Knowles and Daniel Nestor were the defending champions, but lost in semifinals to Bob Bryan and Mike Bryan.
Mark Knowles and Daniel Nestor were the defending champions and successfully defended their title, defeating Leander Paes and Nenad Zimonjić 3–6, 6–3, 6–2 in the final. It was the 39th doubles title for Knowles and the 41st doubles title for Nestor, in their respective careers. It was also the 4th and final title of the year for the pair.
Wayne Black and Kevin Ullyett were the defending champions, but lost in second round to Mario Ančić and Ivan Ljubičić.
Jonas Björkman and Max Mirnyi were the defending champions, but lost in quarterfinals to Fabrice Santoro and Nenad Zimonjić.
Michaël Llodra and Fabrice Santoro were the defending champions, but had different outcomes. While Llodra did not compete this year, Santoro partnered with Nenad Zimonjić and reached the Quarterfinals, before losing to Jonas Björkman and Max Mirnyi.
Jonas Björkman and Max Mirnyi were the defending champions and successfully defended their title, defeating Bob and Mike Bryan 3–6, 6–3, [10–7] in the final.
Mahesh Bhupathi and Max Mirnyi were the defending champions, but played this tournament with different partners. Bhupathi teamed up with Todd Woodbridge while Mirnyi teamed up with Jonas Björkman. Both pairs were eliminated in semifinals.
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Fabrice Santoro 
Nenad Zimonjić 
František Čermák 
