| Rd | Date and local time | Opponent | Scores (Hawthorn's scores indicated in bold) | Venue | Attendance | Record |
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| Home | Away | Result |
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| 1 | Saturday, 31 March (7:15 pm) | Brisbane Lions | 9.15 (69) | 6.8 (44) | Lost by 25 points | The Gabba (A) | 27,104 | 0–1 |
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| 2 | Monday, 9 April (2:10 pm) | Melbourne | 17.14 (116) | 14.10 (94) | Won by 22 points | Melbourne Cricket Ground (H) | 43,197 | 1–1 |
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| 3 | Sunday, 15 April (5:10 pm) | Kangaroos | 10.10 (70) | 13.13 (91) | Won by 21 points | Telstra Dome (A) | 28,481 | 2–1 |
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| 4 | Sunday, 22 April (1:10 pm) | Geelong | 10.16 (76) | 9.18 (72) | Won by 4 points | Aurora Stadium (H) | 17,120 | 3–1 |
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| 5 | Sunday, 29 April (2:10 pm) | Western Bulldogs | 13.15 (93) | 16.14 (110) | Lost by 17 points | Melbourne Cricket Ground (H) | 31,982 | 3–2 |
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| 6 | Saturday, 5 May (2:10 pm) | Essendon | 15.6 (96) | 20.11 (131) | Won by 35 points | Melbourne Cricket Ground (A) | 52,047 | 4–2 |
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| 7 | Sunday, 13 May (2:40 pm) | Fremantle | 14.12 (96) | 11.14 (80) | Lost by 16 points | Subiaco Oval (A) | 36,481 | 4–3 |
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| 8 | Saturday, 19 May (7:10 pm) | St Kilda | 10.12 (72) | 6.8 (44) | Won by 28 points | Melbourne Cricket Ground (H) | 36,069 | 5–3 |
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| 9 | Saturday, 26 May (2:10 pm) | West Coast | 15.9 (99) | 8.16 (64) | Won by 25 points | Aurora Stadium (H) | 18,112 | 6–3 |
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| 10 | Sunday, 3 June (1:10 pm) | Port Adelaide | 10.15 (75) | 17.7 (109) | Won by 34 points | AAMI Stadium (A) | 23,945 | 7–3 |
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| 11 | Saturday, 9 June (2:10 pm) | Sydney | 9.12 (66) | 11.9 (75) | Lost by 9 points | Melbourne Cricket Ground (H) | 48,398 | 7–4 |
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| 12 | Friday, 15 June (7:40 pm) | Carlton | 12.8 (80) | 27.18 (180) | Won by 100 points | Telstra Dome (A) | 53,459 | 8–4 |
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| 13 | Sunday, 1 July (5:10 pm) | Collingwood | 12.15 (87) | 15.5 (95) | Won by 8 points | Telstra Dome (A) | 50,248 | 9–4 |
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| 14 | Saturday, 7 July (7:10 pm) | Adelaide | 15.12 (102) | 4.7 (31) | Lost by 71 points | AAMI Stadium (A) | 34,733 | 9–5 |
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| 15 | Sunday, 15 July (2:10 pm) | Richmond | 19.15 (129) | 11.10 (76) | Won by 53 points | Melbourne Cricket Ground (H) | 41,770 | 10–5 |
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| 16 | Saturday, 21 July (7:10 pm) | St Kilda | 14.11 (95) | 11.12 (78) | Lost by 17 points | Telstra Dome (A) | 37,847 | 10–6 |
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| 17 | Sunday, 29 July (1:10 pm) | Kangaroos | 10.11 (71) | 16.12 (108) | Lost by 37 points | Aurora Stadium (H) | 19,114 | 10–7 |
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| 18 | Sunday, 5 August (2:10 pm) | Essendon | 17.17 (119) | 7.14 (56) | Won by 63 points | Melbourne Cricket Ground (H) | 55,019 | 11–7 |
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| 19 | Saturday, 11 August (2:10 pm) | Brisbane Lions | 17.13 (115) | 13.13 (91) | Won by 24 points | Melbourne Cricket Ground (H) | 39,007 | 12–7 |
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| 20 | Sunday, 19 August (1:10 pm) | Port Adelaide | 12.10 (82) | 12.15 (87) | Lost by 5 points | Aurora Stadium (H) | 15,264 | 12–8 |
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| 21 | Sunday, 26 August (1:10 pm) | Western Bulldogs | 10.7 (67) | 22.19 (151) | Won by 84 points | Telstra Dome (A) | 32,734 | 13–9 |
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| 22 | Sunday, 2 September (1:10 pm) | Sydney | 22.9 (141) | 10.9 (69) | Lost by 72 points | Sydney Cricket Ground (A) | 27,498 | 13–10 |
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