The Second Stage of the 2010 Copa Santander Libertadores was a group stage. It was contested from February 9 to April 22.
Twenty-six teams qualified directly into this round, plus six that advanced from the First Stage. This brings the total number of teams in the Second Stage to 32. The teams were drawn into eight groups of four. The teams in each group will play each other in a double round-robin format, playing the other teams in the group once at home and once away. Teams will be awarded 3 points for a win, 1 point for a draw, and 0 points for a loss. The following criteria will be used for breaking ties on points:
The top team from each group advances to the Round of 16, accompanied by the 6 best runners-up.
| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | COR | RCM | DIM | CER | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | | 6 | 5 | 1 | 0 | 9 | 3 | +6 | 16 | — | 2–1 | 1–0 | 2–1 | |
| 2 | | 6 | 2 | 2 | 2 | 4 | 5 | −1 | 8 | 0–2 | — | 1–0 | 2–1 | |
| 3 | | 6 | 1 | 3 | 2 | 3 | 4 | −1 | 6 | 1–1 | 0–0 | — | 1–0 | |
| 4 | | 6 | 0 | 2 | 4 | 3 | 7 | −4 | 2 | 0–1 | 0–0 | 1–1 | — |
| Cerro Porteño | 1–1 | |
|---|---|---|
| Ramírez | Report | Pardo |
| Corinthians | 2–1 | |
|---|---|---|
| Elias | Report | Cauteruccio |
| Racing | 2–1 | |
|---|---|---|
| Mirabaje Cauteruccio | Report | Cáceres |
| Independiente Medellín | 1–1 | |
|---|---|---|
| Valoyes | Report | Dentinho |
| Cerro Porteño | 0–1 | |
|---|---|---|
| Report | Ronaldo |
| Racing | 1–0 | |
|---|---|---|
| Ostolaza | Report |
| Corinthians | 2–1 | |
|---|---|---|
| Ronaldo Chicão | Report | dos Santos |
| Racing | 0–2 | |
|---|---|---|
| Report | Dentinho Elias |
| Corinthians | 1–0 | |
|---|---|---|
| Valencia | Report |
| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | SÃO | ONC | MTY | NPR | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | | 6 | 4 | 1 | 1 | 9 | 2 | +7 | 13 | — | 1–0 | 2–0 | 3–0 | |
| 2 | | 6 | 3 | 2 | 1 | 8 | 5 | +3 | 11 | 2–1 | — | 1–1 | 1–0 | |
| 3 | | 6 | 1 | 3 | 2 | 5 | 8 | −3 | 6 | 0–0 | 2–2 | — | 2–1 | |
| 4 | | 6 | 1 | 0 | 5 | 3 | 10 | −7 | 3 | 0–2 | 0–2 | 2–0 | — |
| Nacional | 0–2 | |
|---|---|---|
| Report | Castrillón Santoya |
| São Paulo | 2–0 | |
|---|---|---|
| Washington | Report |
| Once Caldas | 2–1 | |
|---|---|---|
| Uribe Moreno | Report | Rogério Ceni |
| Once Caldas | 1–1 | |
|---|---|---|
| Valencia | Report | Morales |
| Nacional | 0–2 | |
|---|---|---|
| Report | Washington |
| Monterrey | 2–2 | |
|---|---|---|
| Martínez Cardozo | Report | Moreno Castrillón |
| São Paulo | 3–0 | |
|---|---|---|
| Dagoberto Léo Lima Washington | Report |
| Once Caldas | 1–0 | |
|---|---|---|
| Valencia | Report |
| São Paulo | 1–0 | |
|---|---|---|
| Fernandinho | Report |
| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | ELP | ALI | JA | BOL | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | | 6 | 4 | 1 | 1 | 11 | 5 | +6 | 13 | — | 1–0 | 5–1 | 2–0 | |
| 2 | | 6 | 4 | 0 | 2 | 12 | 7 | +5 | 12 | 4–1 | — | 2–0 | 1–0 | |
| 3 | | 6 | 2 | 0 | 4 | 7 | 13 | −6 | 6 | 0–2 | 4–2 | — | 2–0 | |
| 4 | | 6 | 1 | 1 | 4 | 3 | 8 | −5 | 4 | 0–0 | 1–3 | 2–0 | — |
| Estudiantes | 5–1 | |
|---|---|---|
| Boselli Ré González | Report | Tejada |
| Alianza Lima | 4–1 | |
|---|---|---|
| Aguirre Fernández | Report | Sosa |
| Juan Aurich | 2–0 | |
|---|---|---|
| Ciciliano Tejada | Report |
| Bolívar | 0–0 | |
|---|---|---|
| Report |
| Alianza Lima | 2–0 | |
|---|---|---|
| Fernández Tragodara | Report |
| Juan Aurich | 4–2 | |
|---|---|---|
| Guizasola Tejada Manco Ascoy | Report | Sánchez Ovelar |
| Estudiantes | 2–0 | |
|---|---|---|
| Sosa Boselli | Report |
| Juan Aurich | 0–2 | |
|---|---|---|
| Report | Fernández Braña |
| Alianza Lima | 1–0 | |
|---|---|---|
| Fernández | Report |
| Bolívar | 2–0 | |
|---|---|---|
| Flores da Rosa | Report |
| Estudiantes | 1–0 | |
|---|---|---|
| Verón | Report |
| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | LIB | UNI | LAN | BLO | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | | 6 | 3 | 3 | 0 | 10 | 3 | +7 | 12 | — | 1–1 | 1–1 | 4–0 | |
| 2 | | 6 | 2 | 4 | 0 | 5 | 2 | +3 | 10 | 0–0 | — | 2–0 | 0–0 | |
| 3 | | 6 | 2 | 2 | 2 | 6 | 6 | 0 | 8 | 0–2 | 0–0 | — | 1–0 | |
| 4 | | 6 | 0 | 1 | 5 | 3 | 13 | −10 | 1 | 1–2 | 1–2 | 1–4 | — |
| Lanús | 0–2 | |
|---|---|---|
| Report | Rod. Gamarra Velázquez |
| Universitario | 2–0 | |
|---|---|---|
| Alva Labarthe | Report |
| Libertad | 1–1 | |
|---|---|---|
| Ayala | Report | Ramírez |
| Lanús | 0–0 | |
|---|---|---|
| Report |
| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | INT | QUI | CRR | EME | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | | 6 | 3 | 3 | 0 | 8 | 2 | +6 | 12 | — | 3–0 | 2–0 | 2–1 | |
| 2 | | 6 | 3 | 1 | 2 | 5 | 7 | −2 | 10 | 1–1 | — | 2–1 | 1–0 | |
| 3 | | 6 | 2 | 2 | 2 | 5 | 5 | 0 | 8 | 0–0 | 2–0 | — | 0–0 | |
| 4 | | 6 | 0 | 2 | 4 | 2 | 6 | −4 | 2 | 0–0 | 0–1 | 1–2 | — |
| Cerro | 2–0 | |
|---|---|---|
| Dadomo Mora | Report |
| Internacional | 2–1 | |
|---|---|---|
| Nei Alecsandro | Report | Quiroz |
| Deportivo Quito | 1–1 | |
|---|---|---|
| Minda | Report | Giuliano |
| Cerro | 0–0 | |
|---|---|---|
| Report |
| Deportivo Quito | 1–0 | |
|---|---|---|
| Arroyo | Report |
| Internacional | 2–0 | |
|---|---|---|
| Ibáñez Alecsandro | Report |
| Emelec | 0–1 | |
|---|---|---|
| Report | Hurtado |
| Internacional | 3–0 | |
|---|---|---|
| Andrezinho Bolívar Giuliano | Report |
| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | NAC | BAN | MOR | CUE | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | | 6 | 3 | 3 | 0 | 9 | 4 | +5 | 12 | — | 2–2 | 2–0 | 3–2 | |
| 2 | | 6 | 3 | 2 | 1 | 13 | 8 | +5 | 11 | 0–2 | — | 2–1 | 4–1 | |
| 3 | | 6 | 1 | 2 | 3 | 4 | 8 | −4 | 5 | 0–0 | 1–1 | — | 2–1 | |
| 4 | | 6 | 1 | 1 | 4 | 7 | 13 | −6 | 4 | 0–0 | 1–4 | 2–0 | — |
| Deportivo Cuenca | 2–0 | |
|---|---|---|
| Méndez Escalada | Report |
| Morelia | 2–1 | |
|---|---|---|
| Borgetti | Report | Ladines |
| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | VÉL | CRU | CC | ITA | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | | 6 | 4 | 1 | 1 | 10 | 5 | +5 | 13 | — | 2–0 | 2–1 | 4–0 | |
| 2 | | 6 | 3 | 2 | 1 | 12 | 6 | +6 | 11 | 3–0 | — | 4–1 | 2–0 | |
| 3 | | 6 | 2 | 2 | 2 | 8 | 10 | −2 | 8 | 1–1 | 1–1 | — | 1–0 | |
| 4 | | 6 | 0 | 1 | 5 | 4 | 13 | −9 | 1 | 0–1 | 2–2 | 2–3 | — |
| Vélez Sársfield | 2–0 | |
|---|---|---|
| Silva Martínez | Report |
| Colo-Colo | 1–0 | |
|---|---|---|
| Paredes | Report |
| Deportivo Italia | 0–1 | |
|---|---|---|
| Report | López |
| Cruzeiro | 4–1 | |
|---|---|---|
| Thiago Ribeiro Kléber Pedro Ken | Report | Paredes |
| Colo-Colo | 1–1 | |
|---|---|---|
| Paredes | Report | Silva |
| Cruzeiro | 2–0 | |
|---|---|---|
| Fabinho Pedro Ken | Report |
| Cruzeiro | 3–0 | |
|---|---|---|
| Thiago Ribeiro Kléber | Report |
| Colo-Colo | 1–1 | |
|---|---|---|
| Millar | Report | Thiago Ribeiro |
| Vélez Sársfield | 4–0 | |
|---|---|---|
| Zapata López Papa | Report |
| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | UCH | FLA | UC | CAR | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | | 6 | 3 | 3 | 0 | 10 | 6 | +4 | 12 | — | 2–1 | 0–0 | 1–0 | |
| 2 | | 6 | 3 | 1 | 2 | 11 | 9 | +2 | 10 | 2–2 | — | 2–0 | 3–2 | |
| 3 | | 6 | 1 | 4 | 1 | 5 | 5 | 0 | 7 | 2–2 | 2–0 | — | 1–1 | |
| 4 | | 6 | 0 | 2 | 4 | 5 | 11 | −6 | 2 | 1–3 | 1–3 | 0–0 | — |
| Universidad de Chile | 1–0 | |
|---|---|---|
| Olivera | Report |
| Flamengo | 2–0 | |
|---|---|---|
| Léo Moura Adriano | Report |
| Universidad Católica | 2–2 | |
|---|---|---|
| Rubio Silva | Report | Olivera Puch |
| Caracas | 1–3 | |
|---|---|---|
| Castellín | Report | Vágner Love Rodrigo Alvim |
| Universidad de Chile | 2–1 | |
|---|---|---|
| Vargas Seymour | Report | Rodrigo Alvim |
| Universidad Católica | 1–1 | |
|---|---|---|
| Morales | Report | Bustamante |
| Universidad Católica | 2–0 | |
|---|---|---|
| Díaz Silva | Report |