| Mixed doubles | |
|---|---|
| 2010 US Open | |
| Champion |  Liezel Huber Bob Bryan |
| Runner-up |  Květa Peschke  Aisam-ul-Haq Qureshi |
| Final score | 6–4, 6–4 |
Carly Gullickson and Travis Parrott were the defending champions, but lost in the first round to Gisela Dulko and Pablo Cuevas.
Liezel Huber and Bob Bryan won the title, defeating Květa Peschke and Aisam-ul-Haq Qureshi in the final 6–4, 6–4.
Liezel Huber / Bob Bryan (champions)
Cara Black / 
Leander Paes (quarterfinals)
Katarina Srebotnik / 
Nenad Zimonjić (second round) Bethanie Mattek-Sands / 
Daniel Nestor (semifinals)
Rennae Stubbs / 
Dick Norman (first round)
Elena Vesnina / 
Andy Ram (second round) Lisa Raymond / 
Wesley Moodie (quarterfinals) Vania King / 
Horia Tecău (first round)| Semifinals | Final | ||||||||||||
| 1 | Liezel Huber Bob Bryan | 6 | 7 | ||||||||||
| 4 | Bethanie Mattek-Sands Daniel Nestor | 3 | 5 | ||||||||||
| 1 | Liezel Huber Bob Bryan | 6 | 6 | ||||||||||
| Květa Peschke Aisam-ul-Haq Qureshi | 4 | 4 | |||||||||||
| Květa Peschke Aisam-ul-Haq Qureshi | 7 | 7 | |||||||||||
 Anna-Lena Grönefeld  Mark Knowles | 65 | 64 | |||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | L Huber B Bryan | 6 | 6 | ||||||||||||||||||||||||
| Alt |  S-w Hsieh  B Soares | 4 | 3 | 1 | L Huber B Bryan | 5 | 6 | [10] | |||||||||||||||||||
| WC | M Oudin R Harrison | 6 | 7 | WC | M Oudin R Harrison | 7 | 1 | [3] | |||||||||||||||||||
A Hlaváčková  M Mertiňák | 1 | 5 | 1 | L Huber B Bryan | 6 | 7 | |||||||||||||||||||||
 T Bacsinszky  O Marach | 1 | 3 | 7 | L Raymond W Moodie | 4 | 63 | |||||||||||||||||||||
 O Govortsova  M Matkowski | 6 | 6 | O Govortsova M Matkowski | 4 | 65 | ||||||||||||||||||||||
 A Medina Garrigues M López | 1 | 64 | 7 | L Raymond W Moodie | 6 | 7 | |||||||||||||||||||||
| 7 | L Raymond W Moodie | 6 | 7 | 1 | L Huber B Bryan | 6 | 7 | ||||||||||||||||||||
| 4 | B Mattek-Sands D Nestor | 6 | 2 | [10] | 4 | B Mattek-Sands D Nestor | 3 | 5 | |||||||||||||||||||
| WC | B Capra J Sock | 2 | 6 | [7] | 4 | B Mattek-Sands D Nestor | 62 | 6 | [10] | ||||||||||||||||||
 Z Yan R Bopanna | 2 | 4 |  A Rezaï R Ram | 7 | 2 | [5] | |||||||||||||||||||||
| A Rezaï R Ram | 6 | 6 | 4 | B Mattek-Sands D Nestor | 6 | 6 | |||||||||||||||||||||
| Y-j Chan P Hanley | 6 | 6 | Y-j Chan P Hanley | 4 | 3 | ||||||||||||||||||||||
| Alt | A Dulgheru D Marrero | 4 | 2 | Y-j Chan P Hanley | 6 | 5 | [10] | ||||||||||||||||||||
| WC | A Spears S Lipsky | 7 | 7 | WC | A Spears S Lipsky | 2 | 7 | [5] | |||||||||||||||||||
| 5 | R Stubbs D Norman | 64 | 63 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 8 | V King H Tecău | 5 | 6 | [5] | |||||||||||||||||||||||
| K Peschke A-u-H Qureshi | 7 | 4 | [10] | K Peschke A-u-H Qureshi | 5 | 6 | [10] | ||||||||||||||||||||
| WC | J Craybas M Russell | 63 | 7 | [1] |  Y Shvedova J Knowle | 7 | 3 | [4] | |||||||||||||||||||
| Y Shvedova J Knowle | 7 | 5 | [10] | K Peschke A-u-H Qureshi | 3 | 6 | [10] | ||||||||||||||||||||
| WC | C Gullickson T Parrott | 2 | 4 |  G Dulko  P Cuevas | 6 | 2 | [4] | ||||||||||||||||||||
| G Dulko P Cuevas | 6 | 6 | G Dulko P Cuevas | 7 | 7 | ||||||||||||||||||||||
| A Petkovic M Fyrstenberg | 63 | 62 | 3 | K Srebotnik N Zimonjić | 5 | 5 | |||||||||||||||||||||
| 3 | K Srebotnik N Zimonjić | 7 | 7 | K Peschke A-u-H Qureshi | 7 | 7 | |||||||||||||||||||||
| 6 | E Vesnina A Ram | 6 | 66 | [11] | A-L Grönefeld M Knowles | 65 | 64 | ||||||||||||||||||||
| WC | R Kops-Jones E Butorac | 4 | 7 | [9] | 6 | E Vesnina A Ram | 6 | 3 | [7] | ||||||||||||||||||
| A-L Grönefeld M Knowles | 6 | 6 | A-L Grönefeld M Knowles | 4 | 6 | [10] | |||||||||||||||||||||
| WC | N Gibbs S Querrey | 3 | 2 | A-L Grönefeld M Knowles | 6 | 6 | |||||||||||||||||||||
| D Hantuchová M Bhupathi | 4 | 2 | 2 | C Black L Paes | 3 | 4 | |||||||||||||||||||||
 K Kanepi  R Lindstedt | 6 | 6 | K Kanepi R Lindstedt | 4 | 1 | ||||||||||||||||||||||
| L Hradecká F Čermák | 4 | 5 | 2 | C Black L Paes | 6 | 6 | |||||||||||||||||||||
| 2 | C Black L Paes | 6 | 7 | ||||||||||||||||||||||||
Mahesh Bhupathi and Mary Pierce were the defending champions but Pierce did not compete. Bhupathi partnered with Yan Zi but lost in the second round to Bob Bryan and Venus Williams.
Elena Likhovtseva and Daniel Nestor won the mixed doubles title at the 2007 Australian Open tennis tournament, defeating Victoria Azarenka and Max Mirnyi in the final 6–4, 6–4.
The 2007 French Open mixed doubles tennis tournament was held in Paris, France from 27 May through to 10 June 2007. The defending champions were Katarina Srebotnik and Nenad Zimonjić, but they lost to Nathalie Dechy and Andy Ram in the finals.
Andy Ram and Vera Zvonareva were the defending champions but Zvonareva did not compete. Ram partnered with Nathalie Dechy but lost in the third round to Marcin Matkowski and Cara Black.
Martina Hingis and Mahesh Bhupathi defeated Elena Likhovtseva and Daniel Nestor in the final 6–3, 6–3 to win the mixed doubles title at the 2006 Australian Open. With this win, Bhupathi completed the Career Grand Slam in Mixed Doubles, becoming the 14th player to do so. This was Hingis' first Grand Slam Mixed Doubles title; she would also later complete the Career Grand Slam in this discipline.
Samantha Stosur and Scott Draper defeated Liezel Huber and Kevin Ullyett in the final 6–2, 2–6, [10–6] to win the mixed doubles title at the 2005 Australian Open. This was the first Grand Slam title for both Stosur and Draper, and would be Draper's only Grand Slam title.
Wayne and Cara Black were the defending champions but lost in the second round to Mahesh Bhupathi and Mary Pierce.
Leander Paes and Martina Navratilova were the defending champions but lost in the third round to Wayne and Cara Black.
Jamie Murray and Jelena Janković were the defending champions but Janković did not participate. Murray partnered with Liezel Huber but lost in the semifinals to Bob Bryan and Samantha Stosur.
In the 2009 French Open mixed doubles event Victoria Azarenka and Bob Bryan were the defending champions, but Azarenka chose not to participate, and only Bryan competed in the tournament.
Bryan partnered with Liezel Huber and won in the final 5–7, 7–6(7–5), 10–7, against Vania King and Marcelo Melo.
Liezel Huber and Bob Bryan were the defending champions, but Bryan chose to not compete this year in mixed doubles.
Leander Paes and Cara Black were the defending champions but lost in the quarterfinals to Daniel Nestor and Chan Yung-jan.
Liezel Huber and Bob Bryan were the defending champions, but they lost to Melanie Oudin and Jack Sock in the second round.
Jürgen Melzer and Iveta Benešová were the defending champions, but after receiving a first-round bye, lost in the second round to Dominic Inglot and Laura Robson.
Melanie Oudin and Jack Sock were the defending champions, but were defeated by Sania Mirza and Colin Fleming in the second round.
Bethanie Mattek-Sands and Horia Tecău were the defending champions, but lost in the first round to Lucie Hradecká and František Čermák.
Mike Bryan and Lisa Raymond were the defending champions, but Bryan decided not to compete to focus on winning the Men's Doubles with his brother Bob. Raymond partnered with Bruno Soares.
Donald Johnson and Kimberly Po-Messerli were the defending champions but lost in the quarterfinals to Leoš Friedl and Daniela Hantuchová.
Leoš Friedl and Daniela Hantuchová were the defending champions but decided not to play together. Friedl played with Tina Križan and lost in first round to Mike Bryan and Liezel Huber, while Hantuchová competed with Kevin Ullyett.
Mahesh Bhupathi and Elena Likhovtseva were the defending champions but decided not to play together. Bhupathi played with Paola Suárez and lost in third round to Nenad Zimonjić and Iroda Tulyaganova, while Likhovtseva competed with Bob Bryan and lost in second round to Andy Ram and Anastasia Rodionova.