| 2012 Challenger Ciudad de Guayaquil | |
|---|---|
| Date | 5 – 10 November |
| Edition | 8th |
| Surface | Clay |
| Location | Guayaquil, Ecuador |
| Champions | |
| Singles | |
 Leonardo Mayer | |
| Doubles | |
| Martín Alund / Facundo Bagnis | |
The 2012 Challenger Ciudad de Guayaquil was a professional tennis tournament played on clay courts. It was the eighth edition of the tournament, which was part of the 2012 ATP Challenger Tour. It took place in Guayaquil, Ecuador between 5 and 10 November 2012.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
| ARG | Leonardo Mayer | 71 | 1 |
 ITA | Paolo Lorenzi | 76 | 2 |
 ESP | Rubén Ramírez Hidalgo | 98 | 3 |
| ARG | Guido Pella | 113 | 4 |
| ARG | Martín Alund | 126 | 5 |
 USA | Wayne Odesnik | 138 | 6 |
 POR | Frederico Gil | 142 | 7 |
 RUS | Teymuraz Gabashvili | 181 | 8 |
The following players received wildcards into the singles main draw:
Duilio Beretta 
Alejandro Estrada Emilio Gómez Juan-Sebastian Vivanco The following players received entry as a special exempt into the singles main draw:
The following players received entry from the qualifying draw:
Sergio Galdós 
Daniel Garza Mateo Nicolás Martínez Franco Scaravilli Leonardo Mayer def. Paolo Lorenzi, 6–2, 6–4 Martín Alund / Facundo Bagnis def. Leonardo Mayer / Martín Ríos-Benítez, 7–5, 7–6(7–5)