| 2012 Knoxville Challenger | |
|---|---|
| Date | 5–11 November |
| Edition | 9th |
| Surface | Hard |
| Location | Knoxville, United States |
| Champions | |
| Singles | |
 Michael Russell | |
| Doubles | |
Alex Kuznetsov /  Mischa Zverev | |
The 2012 Knoxville Challenger was a professional tennis tournament played on hard courts. It was the ninth edition of the tournament which was part of the 2012 ATP Challenger Tour. It took place in Knoxville, United States between 5 and 11 November 2012.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
| USA | Jesse Levine | 74 | 1 |
 RUS | Alex Bogomolov Jr. | 96 | 2 |
| USA | Michael Russell | 101 | 3 |
| GER | Mischa Zverev | 140 | 4 |
| USA | Ryan Sweeting | 147 | 5 |
| USA | Bobby Reynolds | 152 | 6 |
| USA | Tim Smyczek | 157 | 7 |
| USA | Denis Kudla | 163 | 8 |
The following players received wildcards into the singles main draw:
Jarryd Chaplin Brandon Ficky Christian Harrison Eric QuigleyThe following players received entry from the qualifying draw:
Michael Russell def. Bobby Reynolds, 6–3, 6–2 Alex Kuznetsov / Mischa Zverev def. 
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