| 2012 Uruguay Open | |
|---|---|
| Date | 29 October – 4 November |
| Edition | 8th |
| Surface | Clay |
| Location | Montevideo, Uruguay |
| Champions | |
| Singles | |
 Horacio Zeballos | |
| Doubles | |
 Nikola Mektić / Antonio Veić | |
The 2012 Uruguay Open was a professional tennis tournament played on clay courts. It was the eighth edition of the tournament which was part of the 2012 ATP Challenger Tour. It took place in Montevideo, Uruguay between October 29 and November 4, 2012.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 POR | João Sousa | 92 | 1 |
 AUT | Andreas Haider-Maurer | 99 | 2 |
 FRA | Guillaume Rufin | 107 | 3 |
 SVN | Blaž Kavčič | 108 | 4 |
| ARG | Guido Pella | 117 | 5 |
 ROU | Adrian Ungur | 118 | 6 |
| ARG | Horacio Zeballos | 120 | 7 |
 NED | Thiemo de Bakker | 130 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry as an alternate into the singles main draw:
The following players received entry as a special exempt into the singles main draw:
The following players received entry from the qualifying draw:
Horacio Zeballos def. 
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