| 2012 Karshi Challenger | |
|---|---|
| Date | 13–19 August |
| Edition | 6th |
| Location | Qarshi, Uzbekistan |
| Champions | |
| Singles | |
 Igor Kunitsyn | |
| Doubles | |
 Hsin-han Lee / Peng Hsien-yin | |
The 2012 Karshi Challenger was a professional tennis tournament played on hard courts. It was the sixth edition of the tournament which was part of the 2012 ATP Challenger Tour. It took place in Qarshi, Uzbekistan between 13 and 19 August 2012.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
| RUS | Igor Kunitsyn | 144 | 1 |
 SRB | Dušan Lajović | 168 | 2 |
| RUS | Konstantin Kravchuk | 207 | 3 |
 CHN | Wu Di | 224 | 4 |
 UKR | Ivan Sergeyev | 232 | 5 |
| UKR | Illya Marchenko | 235 | 6 |
 SVK | Kamil Čapkovič | 237 | 7 |
 AUS | Brydan Klein | 239 | 8 |
The following players received wildcards into the singles main draw:
Sarvar Ikramov Temur Ismailov Sergey Shipilov Nigmat ShofayzievThe following players received entry from the qualifying draw:
Sriram Balaji Denis Matsukevich Adrian Sikora
Dzmitry Zhyrmont Igor Kunitsyn def. Dzmitry Zhyrmont, 7–6(12–10), 6–2 Hsin-han Lee / Peng Hsien-Yin def. Brydan Klein / 
Yasutaka Uchiyama 6–7(5–7), 6–4, [10–4]