| Singles | |
|---|---|
| 2015 BRD Bucharest Open | |
| Champion |  Anna Karolína Schmiedlová |
| Runner-up |  Sara Errani |
| Final score | 7–6(7–3), 6–3 |
Simona Halep was the defending champion, but chose not to participate this year.
Anna Karolína Schmiedlová won the title, defeating Sara Errani in the final, 7–6(7–3), 6–3.
Sara Errani (final) Roberta Vinci (second round)
Monica Niculescu (semifinals)
Julia Görges (second round) Alexandra Dulgheru (second round, retired)
Tereza Smitková (first round) Anna Karolína Schmiedlová (champion) Annika Beck (first round)| Semifinals | Final | ||||||||||||
| 1 | Sara Errani | 5 | 6 | 6 | |||||||||
| 3 | Monica Niculescu | 7 | 1 | 2 | |||||||||
| 1 | Sara Errani | 63 | 3 | ||||||||||
| 7 | Anna Karolína Schmiedlová | 77 | 6 | ||||||||||
| 7 | Anna Karolína Schmiedlová | 6 | 6 | ||||||||||
 Polona Hercog | 4 | 3 | |||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | S Errani | 6 | 77 | ||||||||||||||||||||||||
 Ç Büyükakçay | 2 | 62 | 1 | S Errani | 77 | 6 | |||||||||||||||||||||
 K Bondarenko | 6 | 4 | 4 |  S Pe'er | 65 | 2 | |||||||||||||||||||||
| S Pe'er | 2 | 6 | 6 | 1 | S Errani | 6 | 6 | ||||||||||||||||||||
 A Tatishvili | 6 | 7 | A Tatishvili | 2 | 3 | ||||||||||||||||||||||
 S Vögele | 4 | 5 | A Tatishvili | 5 | |||||||||||||||||||||||
 S Zhang | 6 | 4 | 4 | 5 | A Dulgheru | 2r | |||||||||||||||||||||
| 5 | A Dulgheru | 3 | 6 | 6 | 1 | S Errani | 5 | 6 | 6 | ||||||||||||||||||
| 3 | M Niculescu | 6 | 5 | 6 | 3 | M Niculescu | 7 | 1 | 2 | ||||||||||||||||||
| WC | A Bogdan | 2 | 7 | 2 | 3 | M Niculescu | 6 | 6 | |||||||||||||||||||
| K Kučová | 3 | 77 | 66 |  T Pereira | 2 | 3 | |||||||||||||||||||||
| T Pereira | 6 | 64 | 78 | 3 | M Niculescu | 4 | 6 | 6 | |||||||||||||||||||
| WC | S Cîrstea | 6 | 6 | A Mitu | 6 | 0 | 2 | ||||||||||||||||||||
 S Karatantcheva | 2 | 2 | WC | S Cîrstea | 7 | 2 | 4 | ||||||||||||||||||||
| A Mitu | 1 | 6 | 6 | A Mitu | 5 | 6 | 6 | ||||||||||||||||||||
| 8 | A Beck | 6 | 3 | 3 | |||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 7 | AK Schmiedlová | 6 | 6 | ||||||||||||||||||||||||
| Q |  R-L Jani | 1 | 2 | 7 | AK Schmiedlová | 6 | 6 | ||||||||||||||||||||
| D Allertová | 6 | 3 | 6 | D Allertová | 1 | 2 | |||||||||||||||||||||
| Q | C Dinu | 4 | 6 | 3 | 7 | AK Schmiedlová | 6 | 6 | |||||||||||||||||||
| Q |  P Martić | 3 | 4 |  D Kovinić | 2 | 2 | |||||||||||||||||||||
| D Kovinić | 6 | 6 | D Kovinić | 6 | 68 | 6 | |||||||||||||||||||||
| Q |  D Kasatkina | 64 | 4 | 4 | J Görges | 4 | 710 | 2 | |||||||||||||||||||
| 4 | J Görges | 77 | 6 | 7 | AK Schmiedlová | 6 | 6 | ||||||||||||||||||||
| 6 | T Smitková | 2 | 5 | P Hercog | 4 | 3 | |||||||||||||||||||||
| P Hercog | 6 | 7 | P Hercog | 6 | 6 | ||||||||||||||||||||||
| WC | PM Țig | 6 | 3 | WC | PM Țig | 0 | 2 | ||||||||||||||||||||
 S Soler Espinosa | 4 | 1r | P Hercog | 6 | 6 | ||||||||||||||||||||||
 A Krunić | 6 | 6 | A Krunić | 3 | 3 | ||||||||||||||||||||||
| E Kulichkova | 2 | 4 | A Krunić | 6 | 6 | ||||||||||||||||||||||
| T Babos | 2 | 1 | 2 | R Vinci | 1 | 1 | |||||||||||||||||||||
| 2 | R Vinci | 6 | 6 | ||||||||||||||||||||||||
Yaroslava Shvedova (qualifying competition) Petra Martić (qualified)
Risa Ozaki (second round) Darya Kasatkina (qualified)
Katarzyna Piter (first round)
Maria Sakkari (qualifying competition)
Florencia Molinero (first round)
Elise Mertens (first round)| First round | Second round | Qualifying competition | ||||||||||||||||||
| 1 | Yaroslava Shvedova | 6 | 6 | |||||||||||||||||
| Victoria Kan | 2 | 3 | ||||||||||||||||||
| 1 | Yaroslava Shvedova | 77 | 78 | |||||||||||||||||
 Tamira Paszek | 64 | 66 | ||||||||||||||||||
| Vanda Lukács | 3 | 6 | 3 | |||||||||||||||||
| Tamira Paszek | 6 | 3 | 6 | |||||||||||||||||
| 1 | Yaroslava Shvedova | 3 | 3 | |||||||||||||||||
| Cristina Dinu | 6 | 6 | ||||||||||||||||||
| Yvonne Cavallé Reimers | 6 | 7 | ||||||||||||||||||
| WC | Irina Fetecău | 2 | 5 | |||||||||||||||||
| Yvonne Cavallé Reimers | 2 | 6 | 2 | |||||||||||||||||
| Cristina Dinu | 6 | 3 | 6 | |||||||||||||||||
| Cristina Dinu | 6 | 6 | ||||||||||||||||||
| 8 | Elise Mertens | 1 | 4 | |||||||||||||||||
| First round | Second round | Qualifying competition | ||||||||||||||||||
| 2 | Petra Martić | 77 | 6 | |||||||||||||||||
| Nastja Kolar | 65 | 1 | ||||||||||||||||||
| 2 | Petra Martić | 6 | 6 | |||||||||||||||||
| Gaia Sanesi | 4 | 1 | ||||||||||||||||||
| Jasmin Jebawy | 2 | 2 | ||||||||||||||||||
| Gaia Sanesi | 6 | 6 | ||||||||||||||||||
| 2 | Petra Martić | 6 | 65 | 77 | ||||||||||||||||
| Viktorija Golubic | 4 | 77 | 62 | |||||||||||||||||
| Viktorija Golubic | 7 | 1 | 6 | |||||||||||||||||
| Elena Bogdan | 5 | 6 | 0 | |||||||||||||||||
| Viktorija Golubic | 64 | 6 | 6 | |||||||||||||||||
| Tereza Martincová | 77 | 4 | 2 | |||||||||||||||||
| Tereza Martincová | 6 | 6 | ||||||||||||||||||
| 5 | Katarzyna Piter | 3 | 3 | |||||||||||||||||
| First round | Second round | Qualifying competition | ||||||||||||||||||
| 3 | Risa Ozaki | 7 | 6 | |||||||||||||||||
| Nicole Vaidišová | 5 | 1 | ||||||||||||||||||
| 3 | Risa Ozaki | 77 | 4 | 4 | ||||||||||||||||
| Réka-Luca Jani | 64 | 6 | 6 | |||||||||||||||||
| Réka-Luca Jani | 6 | 6 | ||||||||||||||||||
| WC | Ayla Aksu | 2 | 3 | |||||||||||||||||
| Réka-Luca Jani | 6 | 2 | 6 | |||||||||||||||||
| Mihaela Buzărnescu | 4 | 6 | 3 | |||||||||||||||||
| Mihaela Buzărnescu | 6 | 6 | ||||||||||||||||||
| WC | Jaqueline Cristian | 3 | 4 | |||||||||||||||||
| Mihaela Buzărnescu | 6 | 2 | 6 | |||||||||||||||||
| Irina Maria Bara | 4 | 6 | 3 | |||||||||||||||||
| Irina Maria Bara | 6 | 6 | ||||||||||||||||||
| 7 | Florencia Molinero | 2 | 2 | |||||||||||||||||
| First round | Second round | Qualifying competition | ||||||||||||||||||
| 4 | Daria Kasatkina | 6 | 6 | |||||||||||||||||
| Anastasiya Vasylyeva | 0 | 2 | ||||||||||||||||||
| 4 | Daria Kasatkina | 6 | 6 | |||||||||||||||||
| Cristina Ene | 1 | 2 | ||||||||||||||||||
| Valeriya Strakhova | 2 | 6 | 4 | |||||||||||||||||
| Cristina Ene | 6 | 4 | 6 | |||||||||||||||||
| 4 | Daria Kasatkina | 6 | 7 | |||||||||||||||||
| 6 | Maria Sakkari | 1 | 5 | |||||||||||||||||
| WC | Elena-Gabriela Ruse | 6 | 6 | |||||||||||||||||
| Alexandra Cadanțu | 4 | 4 | ||||||||||||||||||
| WC | Elena-Gabriela Ruse | 2 | 3 | |||||||||||||||||
| 6 | Maria Sakkari | 6 | 6 | |||||||||||||||||
| Aleksandrina Naydenova | 3 | 2 | ||||||||||||||||||
| 6 | Maria Sakkari | 6 | 6 | |||||||||||||||||
Petra Kvitová was the defending champion, but she lost to Sorana Cîrstea in the quarterfinals.
Li Na was the defending women's singles tournament champion, but lost to Serena Williams in the semifinals.
Petra Kvitová was the defending champion, but she was defeated in the final by Simona Halep 6–2, 6–2.
Elena Vesnina was the defending champion, but lost in the second round to Madison Keys.
Victoria Azarenka was the defending champion, but withdrew because of a right knee injury.
Kurumi Nara was the defending champion, but chose to compete in Dubai instead.
Alizé Cornet was the defending champion, but lost to Anna Karolína Schmiedlová in the quarterfinals.
Serena Williams was the two-time defending champion, but withdrew before her third round match because of a right elbow injury.
Andrea Petkovic was the defending champion, but she chose not to participate this year.
Samantha Stosur won the title, defeating Karin Knapp in the final, 3–6, 7–6(7–3), 6–2.
Serena Williams was the defending champion and successfully defended her title, defeating Simona Halep in the final, 6–3, 7–6(7–5).
Simona Halep was the defending champion, but lost in the quarterfinals to Serena Williams.
Serena Williams was the three-time defending champion, but lost in the fourth round to Svetlana Kuznetsova.
Anna Karolína Schmiedlová was the defending champion, but lost in the first round to Aliaksandra Sasnovich.
Johanna Larsson was the defending champion, but lost in the semifinals to Kateřina Siniaková.
Simona Halep was the two-time defending champion, but lost to Karolína Plíšková in the quarterfinals.
Anna Karolína Schmiedlová was the defending champion, but lost in the second round to Beatriz Haddad Maia.
This was the first edition of the tournament, primarily organised due to the cancellation of many tournaments during the 2020 season, because of the ongoing COVID-19 pandemic.
Ashleigh Barty was the defending champion from when the tournament was last held in 2019, and she successfully defended her title after Bianca Andreescu retired from the final with the scoreline at 6–3, 4–0. Barty saved a match point in the second round against Kristína Kučová en route to the title. The victory earned Barty her first successful title defense in her singles career and made her the sixth woman to accomplish a title defense at the Miami Open.
This was the first edition of the tournament.
Ons Jabeur defeated Jessica Pegula in the final, 7–5, 0–6, 6–2 to win the women's singles tennis title at the 2022 Madrid Open. It was her first WTA 1000 title, and she became the first Arab and African woman to win a WTA 1000 title. Pegula reached the final after saving a match point in her first round match against Camila Giorgi.