Simona Halep was the defending champion, but lost in the quarterfinals to Serena Williams.
Roberta Vinci was the defending champion, but lost in the quarterfinals to unseeded Kristina Mladenovic.
Daria Kasatkina was the defending champion, but lost in the quarterfinals to Julia Görges.
Garbiñe Muguruza was the defending champion, but lost in the second round to Lesia Tsurenko.
Daria Gavrilova was the defending champion, but lost to Aryna Sabalenka in the second round.
Petra Kvitová was the defending champion, but lost to Donna Vekić in the quarterfinals.
Elina Svitolina was the two-time defending champion, but lost in the semifinals to Belinda Bencic.
Ashleigh Barty defeated Karolína Plíšková in the final, 7–6(7–1), 6–3, to win the women's singles tennis title at the 2019 Miami Open. It marked Barty's first Miami Open title and her first WTA Premier Mandatory title. Her victory earned her a top 10 debut in the WTA rankings.
Caroline Wozniacki was the defending champion, but lost in the third round to Aryna Sabalenka in a rematch of the previous year's final.
This was the first edition of the event.
Kiki Bertens was the defending champion and successfully defended her title, defeating Elena Rybakina in the final, 6–1, 6–3. This would be Bertens' final WTA Tour singles title before her retirement in July 2021.
Elise Mertens was the defending champion, but lost in the second round to Yulia Putintseva.
Jil Teichmann was the defending champion, but chose not to participate.
Madison Keys was the defending champion but lost in the second round to Ons Jabeur.
Naomi Osaka defeated Jennifer Brady in the final, 6–4, 6–3 to win the women's singles tennis title at the 2021 Australian Open. It was her second Australian Open title and fourth major singles title overall. With the win, Osaka extended her winning streak to 21 matches, dating back to the 2020 Cincinnati Open. She only lost one set during the tournament, to Garbiñe Muguruza in the fourth round; she also saved two match points in that match, making her the eighth woman to win the Australian Open after saving match points. Osaka became the first woman to win her fourth major singles title since Maria Sharapova in 2012, and the youngest since Justine Henin won the 2005 French Open. She also became the third player in the Open Era, after Monica Seles and Roger Federer, to win their first four major finals.
Ashleigh Barty was the defending champion from when the tournament was last held in 2019, and she successfully defended her title after Bianca Andreescu retired from the final with the scoreline at 6–3, 4–0. Barty saved a match point in the second round against Kristína Kučová en route to the title. The victory earned Barty her first successful title defense in her singles career and made her the sixth woman to accomplish a title defense at the Miami Open.
Aryna Sabalenka defeated Ashleigh Barty in the final, 6–0, 3–6, 6–4, to win the women's singles tennis title at the 2021 Madrid Open. It was Sabalenka's 10th career WTA Tour singles title and her first title on clay.
Anett Kontaveit defeated Maria Sakkari in the final, 5–7, 7–6(7–4), 7–5 to win the singles title at the 2022 St. Petersburg Ladies' Trophy. Kontaveit's victory in the final was her 20th consecutive match win on indoor hard courts, dating back to the 2021 Ostrava Open; this is the longest such streak since Justine Henin won 22 matches on indoor courts between October 2007 and May 2010.
Iga Świątek defeated Naomi Osaka in the final, 6–4, 6–0 to win the women's singles title at the 2022 Miami Open. She became the fourth woman in history, after Steffi Graf, Kim Clijsters, and Victoria Azarenka, to complete the Sunshine Double in singles, having won Indian Wells two weeks earlier. It was Świątek's first Miami Open title, her third consecutive WTA 1000 title, and her fourth WTA 1000-level title overall. Świątek became the first woman in history to win the first three WTA 1000 titles of the year in succession, the first player since Serena Williams in 2013 to win three consecutive WTA 1000 titles, and extended her win streak to 17 matches. She lost no sets and just 26 games en route to the title, the fewest since Martina Hingis dropped 21 games in 2000.
Ons Jabeur defeated Jessica Pegula in the final, 7–5, 0–6, 6–2 to win the women's singles tennis title at the 2022 Madrid Open. It was her first WTA 1000 title, and she became the first Arab and African woman to win a WTA 1000 title. Pegula reached the final after saving a match point in her first round match against Camila Giorgi.
Belinda Bencic 
Anastasia Pavlyuchenkova 
