| Doubles | |
|---|---|
| 2020 Cary Challenger | |
| Champions |  Teymuraz Gabashvili  Dennis Novikov |
| Runners-up |  Luke Bambridge Nathaniel Lammons |
| Score | 7–5, 4–6, [10–8] |
Sekou Bangoura and Michael Mmoh were the defending champions [1] but chose not to defend their title.
Teymuraz Gabashvili and Dennis Novikov won the title after defeating Luke Bambridge and Nathaniel Lammons 7–5, 4–6, [10–8] in the final.
Luke Bambridge / Nathaniel Lammons (final)
André Göransson / 
Ramkumar Ramanathan (first round)
Hans Hach Verdugo / Miguel Ángel Reyes-Varela (first round)
Andrey Golubev / Aleksandr Nedovyesov (quarterfinals)| First round | Quarterfinals | Semifinals | Final | ||||||||||||||||||||||||
| 1 | L Bambridge N Lammons | 7 | 5 | [10] | |||||||||||||||||||||||
| D Kudla T-S Kwiatkowski | 5 | 7 | [1] | 1 | L Bambridge N Lammons | 77 | 3 | [10] | |||||||||||||||||||
 S Doumbia F Reboul | 6 | 6 | S Doumbia F Reboul | 65 | 6 | [7] | |||||||||||||||||||||
| WC |  Eduard Güell Bartrina Sean Sculley | 4 | 4 | 1 | L Bambridge N Lammons | w/o | |||||||||||||||||||||
| 3 | H Hach Verdugo MÁ Reyes-Varela | 4 | 5 | N Pasha Ma Redlicki | |||||||||||||||||||||||
| WC | W Blumberg Brian Cernoch | 6 | 7 | WC | W Blumberg B Cernoch | 3 | 2 | ||||||||||||||||||||
| N Pasha Ma Redlicki | 77 | 6 | N Pasha Ma Redlicki | 6 | 6 | ||||||||||||||||||||||
| M Krueger J Withrow | 62 | 3 | 1 | L Bambridge N Lammons | 5 | 6 | [8] | ||||||||||||||||||||
| WC |  T Babelis Robin Catry | 2 | 6 | [6] | T Gabashvili D Novikov | 7 | 4 | [10] | |||||||||||||||||||
| T Gabashvili D Novikov | 6 | 3 | [10] | T Gabashvili D Novikov | 4 | 6 | [10] | ||||||||||||||||||||
R Galloway  T Huey | 1 | 6 | [7] | 4 | A Golubev A Nedovyesov | 6 | 4 | [3] | |||||||||||||||||||
| 4 | A Golubev A Nedovyesov | 6 | 4 | [10] | T Gabashvili D Novikov | 7 | 66 | [10] | |||||||||||||||||||
 R Cid Subervi  DE Galán | 64 | 2 | H Reese  S Verbeek | 5 | 78 | [8] | |||||||||||||||||||||
 P Polansky D Popko | 77 | 6 | P Polansky D Popko | 66 | 5 | ||||||||||||||||||||||
| H Reese S Verbeek | 6 | 6 | H Reese S Verbeek | 78 | 7 | ||||||||||||||||||||||
| 2 | A Göransson R Ramanathan | 1 | 4 | ||||||||||||||||||||||||
Peter Polansky and Neal Skupski were the defending champions but chose not to defend their title.
James Cerretani and Leander Paes were the defending champions but only Cerretani chose to defend his title, partnering Marcelo Arévalo. Cerretani lost in the quarterfinals to Miomir Kecmanović and Darian King.
Federico Delbonis and Máximo González were the defending champions and successfully defended the title, defeating Luke Bambridge and Jonny O'Mara in the final, 6–4, 6–3.
Evan King and Hunter Reese were the defending champions but only Reese chose to defend his title, partnering André Göransson. Reese lost in the first round to Treat Huey and Fabrice Martin.
Luke Bambridge and Akira Santillan were the defending champions but chose not to defend their title.
Santiago González and Wesley Koolhof were the defending champions but chose not to defend their title.
Luke Bambridge and Jonny O'Mara were the defending champions but chose to defend their title with different partners. Bambridge played alongside Ben McLachlan, but lost in the first round to Wesley Koolhof and Fabrice Martin. O'Mara teamed up with Ken Skupski, but lost in the first round to Mate Pavić and Bruno Soares.
Austin Krajicek and Nicholas Monroe were the defending champions but chose not to defend their title.
Robert Galloway and Nathaniel Lammons were the defending champions but only Lammons chose to defend his title, partnering Hunter Reese. Lammons lost in the first round to Sekou Bangoura and Sebastian Korda.
Romain Arneodo and Andrei Vasilevski were the defending champions but chose not to defend their title.
Bob and Mike Bryan were the defending champions and successfully defended their title, defeating Luke Bambridge and Ben McLachlan in the final, 3–6, 7–5, [10–5].
Martin Redlicki and Jackson Withrow were the defending champions but only Redlicki chose to defend his title, partnering Diego Hidalgo. Redlicki lost in the first round to Nam Ji-sung and Song Min-kyu.
This was the first edition of the tournament.
Santiago González and Aisam-ul-Haq Qureshi were the defending champions but chose not to defend their title.
Simone Bolelli and Máximo González were the defending champions but Bolelli chose not to participate. González was scheduled to partner Nicolás Jarry, but Jarry withdrew with a right elbow injury before their first round match.
Martín Cuevas and Paolo Lorenzi were the defending champions but chose not to defend their title.
William Blumberg and Max Schnur were the defending champions but only Blumberg chose to defend his title, partnering Luke Saville. Blumberg lost in the first round to Juan Pablo Ficovich and Facundo Mena.
Nathaniel Lammons and Jackson Withrow defeated Jason Kubler and Luke Saville in the final, 7–6(7–5), 6–2 to win the doubles tennis title at the 2022 San Diego Open.
Ivan Dodig and Austin Krajicek defeated Nicolas Mahut and Édouard Roger-Vasselin in the final, 6–4, 7–6(7–5) to win the doubles tennis title at the 2022 Swiss Indoors.
Nikola Mektić and Mate Pavić defeated Nathaniel Lammons and Jackson Withrow in the final, 6–4, 6–7(5–7), [10–6] to win the men's doubles tennis title at the 2023 ASB Classic.