Draw
The draw for the group stage was held on 9 April 2021, 12:00 PYT (UTC−4), at the CONMEBOL Convention Centre in Luque, Paraguay. [3] [4]
Teams were seeded by their CONMEBOL Clubs ranking as of 1 February 2021 (shown in parentheses), [5] [6] taking into account the following three factors: [7]
- Performance in the last 10 years, taking into account Copa Libertadores and Copa Sudamericana results in the period 2011–2020.
- Historical coefficient, taking into account Copa Libertadores and Copa Sudamericana results in the period 1960–2010 and 2002–2010 respectively.
- Local tournament champion, with bonus points awarded to domestic league champions of the last 10 years.
For the group stage, the 32 teams were drawn into eight groups (Groups A–H) of four containing a team from each of the four pots. Teams from the same association could not be drawn into the same group, excluding the four winners of the third stage, which were seeded in Pot 4 and whose identity was not known at the time of the draw, and could be drawn into the same group with another team from the same association.
| Pot 1 | Pot 2 | Pot 3 | Pot 4 |
|---|---|---|---|
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- Notes
- ^ TH The defending Copa Libertadores champions were seeded in Pot 1 and automatically allocated to Group A.
- ^ CS The defending Copa Sudamericana champions were seeded in Pot 2.
The following were the four winners of the third stage of qualifying which joined the 28 direct entrants in the group stage.
| Match | Third stage winners |
|---|---|
| G1 |  Atlético Nacional (7) |
| G2 |  Independiente del Valle (20) |
| G3 | Junior (27) |
| G4 |  Santos (9) |
