| Doubles | |
|---|---|
| 2021 Potchefstroom Open | |
| Champions |  Marc-Andrea Hüsler  Zdeněk Kolář |
| Runners-up |  Peter Polansky Brayden Schnur |
| Final score | 6–4, 2–6, [10–4] |
This was the second edition of the tournament. There was no defending champion as the tournament was canceled at the quarterfinals stage due to the COVID-19 pandemic. [1]
Marc-Andrea Hüsler and Zdeněk Kolář won the title after defeating Peter Polansky and Brayden Schnur 6–4, 2–6, [10–4] in the final.
Raven Klaasen / Ruan Roelofse (semifinals) Marc-Andrea Hüsler / Zdeněk Kolář (champions)
Benjamin Bonzi / Tristan Lamasine (first round)
Teymuraz Gabashvili / 
Mark Vervoort (first round)| First round | Quarterfinals | Semifinals | Final | ||||||||||||||||||||||||
| 1 | R Klaasen R Roelofse | 6 | 6 | ||||||||||||||||||||||||
| WC | Vasilios Caripi Vaughn Hunter | 3 | 2 | 1 | R Klaasen R Roelofse | 6 | 7 | ||||||||||||||||||||
| PR |  J Cagnina  N Kuhn | 6 | 6 | PR | J Cagnina N Kuhn | 1 | 5 | ||||||||||||||||||||
| WC | Devin Badenhorst Pierre Malan | 3 | 4 | 1 | R Klaasen R Roelofse | 3 | 4 | ||||||||||||||||||||
| 4 | T Gabashvili M Vervoort | 3 | 64 | P Polansky B Schnur | 6 | 6 | |||||||||||||||||||||
| P Polansky B Schnur | 6 | 77 | P Polansky B Schnur | 78 | 3 | [10] | |||||||||||||||||||||
 D Kuzmanov  R Quiroz | 6 | 6 | D Kuzmanov R Quiroz | 66 | 6 | [8] | |||||||||||||||||||||
| WC | Robbie Arends Khololwam Montsi | 3 | 2 | P Polansky B Schnur | 4 | 6 | [4] | ||||||||||||||||||||
 L Broady J Draper | 77 | 7 | 2 | M-A Hüsler Z Kolář | 6 | 2 | [10] | ||||||||||||||||||||
 B Lock  A Santillan | 65 | 5 | L Broady J Draper | 3 | 6 | [10] | |||||||||||||||||||||
 R Cid Subervi  A Kadhe | 4 | 6 | [10] | R Cid Subervi A Kadhe | 6 | 4 | [6] | ||||||||||||||||||||
| 3 | B Bonzi T Lamasine | 6 | 4 | [4] | L Broady J Draper | 64 | 3 | ||||||||||||||||||||
G Blancaneaux  C İlkel | 4 | 4 | 2 | M-A Hüsler Z Kolář | 77 | 6 | |||||||||||||||||||||
A Menéndez Maceiras  L Miedler | 6 | 6 | A Menéndez Maceiras L Miedler | 63 | 6 | [7] | |||||||||||||||||||||
| Alt | J de Jong V Kopřiva | 3 | 4 | 2 | M-A Hüsler Z Kolář | 77 | 3 | [10] | |||||||||||||||||||
| 2 | M-A Hüsler Z Kolář | 6 | 6 | ||||||||||||||||||||||||
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