| Singles | |
|---|---|
| 2022 Las Vegas Challenger | |
| Champion |  Tennys Sandgren |
| Runner-up | Stefan Kozlov |
| Score | 7–5, 6–3 |
J. J. Wolf was the defending champion [1] but chose not to defend his title.
Tennys Sandgren won the title after defeating Stefan Kozlov 7–5, 6–3 in the final.
Denis Kudla (first round) Steve Johnson (semifinals)
Vasek Pospisil (first round) Stefan Kozlov (final)
Juan Pablo Ficovich (quarterfinals, retired) Ben Shelton (second round) Facundo Mena (first round) Aleksandar Kovacevic (second round)| Semifinals | Final | ||||||||||||
 Shang Juncheng | 3 | 65 | |||||||||||
| Q | Tennys Sandgren | 6 | 77 | ||||||||||
| Q | Tennys Sandgren | 7 | 6 | ||||||||||
| 4 | Stefan Kozlov | 5 | 3 | ||||||||||
| 4 | Stefan Kozlov | 6 | 1 | 7 | |||||||||
| 2 | Steve Johnson | 3 | 6 | 5 | |||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | D Kudla | 4 | 3 | ||||||||||||||||||||||||
| Q | A Perez | 6 | 6 | Q | A Perez | 63 | 6 | 3 | |||||||||||||||||||
| J Shang | 6 | 3 | 6 | J Shang | 77 | 4 | 6 | ||||||||||||||||||||
| WC |  A Cozbinov | 4 | 6 | 3 | J Shang | 6 | 3 | 6 | |||||||||||||||||||
| E Escobedo | 6 | 6 | E Escobedo | 4 | 6 | 3 | |||||||||||||||||||||
| Q | O Kumar | 1 | 4 | E Escobedo | 6 | 6 | |||||||||||||||||||||
 V Vacherot | 77 | 64 | 4 | 6 | B Shelton | 2 | 3 | ||||||||||||||||||||
| 6 | B Shelton | 64 | 77 | 6 | J Shang | 3 | 65 | ||||||||||||||||||||
| 3 | V Pospisil | 4 | 6 | 2 | Q | T Sandgren | 6 | 77 | |||||||||||||||||||
| Q |  J Pinnington Jones | 6 | 3 | 6 | Q | J Pinnington Jones | 5 | 3 | |||||||||||||||||||
| Q | T Sandgren | 3 | 7 | 6 | Q | T Sandgren | 7 | 6 | |||||||||||||||||||
 S Fanselow | 6 | 5 | 3 | Q | T Sandgren | 67 | 6 | 6 | |||||||||||||||||||
| WC |  Maxim Verboven | 2 | 2 | B Holt | 79 | 2 | 3 | ||||||||||||||||||||
| B Holt | 6 | 6 | B Holt | 77 | 7 | ||||||||||||||||||||||
| Em Nava | 67 | 2 | 8 | A Kovacevic | 61 | 5 | |||||||||||||||||||||
| 8 | A Kovacevic | 79 | 6 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 7 | F Mena | 1 | 6 | 4 | |||||||||||||||||||||||
| A Galarneau | 6 | 0 | 6 | A Galarneau | 6 | 2 | |||||||||||||||||||||
| Alt | G Nanda | 77 | 6 | Alt | G Nanda | 1 | 1r | ||||||||||||||||||||
 N Mejía | 61 | 4 | A Galarneau | 77 | 4 | 3 | |||||||||||||||||||||
| Q | Aidan Mayo | 4 | 69 | 4 | S Kozlov | 65 | 6 | 6 | |||||||||||||||||||
| E Zhu | 6 | 711 | E Zhu | 65 | 2 | ||||||||||||||||||||||
| WC | C Kingsley | 5 | 6 | 1 | 4 | S Kozlov | 77 | 6 | |||||||||||||||||||
| 4 | S Kozlov | 7 | 4 | 6 | 4 | S Kozlov | 6 | 1 | 7 | ||||||||||||||||||
| 5 | JP Ficovich | 6 | 7 | 2 | S Johnson | 3 | 6 | 5 | |||||||||||||||||||
| P Jubb | 3 | 5 | 5 | JP Ficovich | 3 | 77 | 6 | ||||||||||||||||||||
| G Diallo | 6 | 6 | G Diallo | 6 | 65 | 4 | |||||||||||||||||||||
 E Couacaud | 4 | 4 | 5 | JP Ficovich | 1 | 0r | |||||||||||||||||||||
| M Krueger | 7 | 6 | 2 | S Johnson | 6 | 0 | |||||||||||||||||||||
| Q |  S Carr | 5 | 4 | M Krueger | 5 | 3 | |||||||||||||||||||||
 G Elias | 7 | 3 | 5 | 2 | S Johnson | 7 | 6 | ||||||||||||||||||||
| 2 | S Johnson | 5 | 6 | 7 | |||||||||||||||||||||||
Gianluigi Quinzi was the defending champion, but was no longer eligible to compete in junior tennis, and thus could not defend his title.
Thanasi Kokkinakis and Nick Kyrgios were the defending champions, but were no longer eligible to compete in junior tennis.
John Millman was the defending champion but chose not to defend his title.
Dudi Sela was the defending champion but chose not to defend his title.
Mikael Torpegaard was the defending champion but lost in the first round to Taylor Fritz.
Sam Querrey defeated Rafael Nadal in the final, 6–3, 7–6(7–3) to win the men's singles tennis title at the 2017 Mexican Open.
Nick Kyrgios was the defending champion, but withdrew before the tournament began.
Stefan Kozlov was the defending champion but chose not to defend his title.
Sam Groth was the defending champion but retired in the second round against Jan Choinski.
Steve Johnson was the defending champion and successfully defended his title, defeating Tennys Sandgren in the final, 7–6(7–2), 2–6, 6–4.
Alexander Zverev defeated top seed Stefanos Tsitsipas in the final, 6–4, 7–6(7–3) to win the men's singles tennis title at the 2021 Mexican Open.
J. J. Wolf was the defending champion but lost in the semifinals to Stefan Kozlov.
Treat Huey and Nathaniel Lammons were the defending champions but chose not to defend their title.
Vasek Pospisil was the defending champion but chose not to defend his title.
J. J. Wolf was the defending champion but lost in the semifinals to Stefan Kozlov.
Cameron Norrie defeated Reilly Opelka in the final, 7–6(7–1), 7–6(7–4) to win the singles title at the 2022 Delray Beach Open.
Federico Coria was the defending champion but chose not to defend his title.
Wu Yibing defeated Aleksandar Kovacevic in the final, 6–7(10–12), 7–6(15–13), 6–3, to win the singles tennis title at the 2022 Indy Challenger. Wu saved six championship points en route to his third consecutive title on the 2022 ATP Challenger Tour.
Alex de Minaur defeated Jenson Brooksby in the final, 6–3, 6–3 to win the singles title at the 2022 Atlanta Open. It was de Minaur's second Atlanta title, the first being in 2019.
Stefan Kozlov was the defending champion but lost in the second round to Lucas Gerch.