| 2023 Challenger Santa Fe II | |
|---|---|
| Date | 16 – 21 October |
| Edition | 2nd |
| Surface | Clay |
| Location | Santa Fe, Argentina |
| Champions | |
| Singles | |
 Mariano Navone | |
| Doubles | |
 Luca Margaroli / Santiago Rodríguez Taverna | |
The 2023 Challenger Santa Fe II was a professional tennis tournament played on clay courts. It was the second edition of the tournament which was part of the 2023 ATP Challenger Tour. It took place in Santa Fe, Argentina between 16 and 21 October 2023.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
| ARG | Federico Coria | 83 | 1 |
| ARG | Juan Manuel Cerúndolo | 102 | 2 |
 CHI | Tomás Barrios Vera | 108 | 3 |
 CZE | Vít Kopřiva | 114 | 4 |
| ARG | Francisco Comesaña | 126 | 5 |
 GBR | Jan Choinski | 127 | 6 |
| ARG | Genaro Alberto Olivieri | 131 | 7 |
 BRA | Felipe Meligeni Alves | 143 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw as an alternate:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
Mariano Navone def. 
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