| 2024 Knoxville Challenger | |
|---|---|
| Date | 4–10 November |
| Edition | 20th |
| Surface | Hard (Indoor) |
| Location | Knoxville, United States |
| Champions | |
| Singles | |
 Christopher Eubanks | |
| Doubles | |
 Patrick Harper /  Johannus Monday | |
The 2024 Knoxville Challenger was a professional tennis tournament played on indoor hard courts. It was the 20th edition of the tournament which was part of the 2024 ATP Challenger Tour. It took place in Knoxville, United States between 4 and 10 November 2024.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
| AUS | Adam Walton | 92 | 1 |
| USA | Christopher Eubanks | 119 | 2 |
| USA | Learner Tien | 125 | 3 |
| USA | Mitchell Krueger | 144 | 4 |
| USA | Zachary Svajda | 165 | 5 |
| USA | Patrick Kypson | 169 | 6 |
 ARG | Juan Pablo Ficovich | 174 | 7 |
 KAZ | Dmitry Popko | 175 | 8 |
The following players received wildcards into the singles main draw:
Murphy Cassone 
Shunsuke Mitsui Colton Smith The following player received entry into the singles main draw as a special exempt:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Micah Braswell Stefan Dostanic Toby Kodat Alexander Kotzen Kenta Miyoshi
Max Wiskandt Christopher Eubanks def. Learner Tien 7–5, 7–6(11–9). Patrick Harper / Johannus Monday def. Micah Braswell / Eliot Spizzirri 6–2, 6–2.