ABLIM1

Last updated
ABLIM1
Identifiers
Aliases ABLIM1 , ABLIM, LIMAB1, LIMATIN, abLIM-1, actin binding LIM protein 1
External IDs OMIM: 602330 MGI: 1194500 HomoloGene: 40994 GeneCards: ABLIM1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC) Chr 10: 114.43 – 114.77 Mb Chr 19: 57.02 – 57.3 Mb
PubMed search [3] [4]
Wikidata
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Actin binding LIM protein 1, also known as ABLIM1, is a protein which in humans is encoded by the ABLIM1 gene. [5] [6]

Function

This gene encodes a cytoskeletal LIM protein that binds to actin filaments via a domain that is homologous to erythrocyte dematin. LIM domains, found in over 60 proteins, play key roles in the regulation of developmental pathways. LIM domains also function as protein-binding interfaces, mediating specific protein-protein interactions. The protein encoded by this gene could mediate such interactions between actin filaments and cytoplasmic targets. Alternatively spliced transcript variants encoding different isoforms have been identified. [5]

Interactions

ABLIM1 has been shown to interact with LDOC1. [7]

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000099204 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025085 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: ABLIM1 actin binding LIM protein 1".
  6. Roof DJ, Hayes A, Adamian M, Chishti AH, Li T (August 1997). "Molecular characterization of abLIM, a novel actin-binding and double zinc finger protein". The Journal of Cell Biology. 138 (3): 575–88. doi:10.1083/jcb.138.3.575. PMC   2141644 . PMID   9245787.
  7. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.

Further reading