LDOC1

LDOC1
Identifiers
Aliases	LDOC1 , BCUR1, Mar7, Mart7, leucine zipper, down-regulated in cancer 1, regulator of NFKB signaling, SIRH7, RTL7, LDOC1 regulator of NFKB signaling
External IDs	OMIM: 300402; MGI: 2685212; HomoloGene: 32153; GeneCards: LDOC1; OMA:LDOC1 - orthologs
Gene location (Human) Chr. X chromosome (human) [1] Band Xq27.1 Start 141,111,605 bp [1] End 141,177,129 bp [1]
Gene location (Mouse) Chr. X chromosome (mouse) [2] Band X|X A6 Start 60,753,103 bp [2] End 60,754,561 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Descending thoracic aorta ascending aorta right coronary artery popliteal artery tibial arteries anterior pituitary prefrontal cortex left coronary artery right frontal lobe dorsolateral prefrontal cortex Top expressed in lumbar subsegment of spinal cord facial motor nucleus embryo embryo blastocyst cerebellar cortex substantia nigra yolk sac anterior horn of spinal cord decidua More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component nucleus nucleolus Biological process maternal placenta development maternal process involved in parturition regulation of growth hormone activity negative regulation of cell population proliferation cellular response to lipopolysaccharide cellular response to muramyl dipeptide Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23641 434784 Ensembl ENSG00000182195 ENSMUSG00000057615 UniProt O95751 Q7TPY9 RefSeq (mRNA) NM_012317 NM_001018087 RefSeq (protein) NP_036449 NP_001018097 Location (UCSC) Chr X: 141.11 – 141.18 Mb Chr X: 60.75 – 60.75 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein LDOC1 is a protein that in humans is encoded by the LDOC1 gene. ^{[5] [6] [7] [8]}

Function

The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers. ^[8]

Interactions

LDOC1 has been shown to interact with ABLIM1. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000182195 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000057615 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagasaki K, Manabe T, Hanzawa H, Maass N, Tsukada T, Yamaguchi K (Jun 1999). "Identification of a novel gene, LDOC1, down-regulated in cancer cell lines". Cancer Letters. 140 (1–2): 227–34. doi:10.1016/S0304-3835(99)00087-7. PMID   10403563.
6. Brandt J, Schrauth S, Veith AM, Froschauer A, Haneke T, Schultheis C, Gessler M, Leimeister C, Volff JN (Jan 2005). "Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals". Gene. 345 (1): 101–11. doi:10.1016/j.gene.2004.11.022. PMID   15716091.
7. Brandt J, Veith AM, Volff JN (Aug 2005). "A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian genomes". Cytogenetic and Genome Research. 110 (1–4): 307–17. doi:10.1159/000084963. PMID   16093683. S2CID   38398479.
8. "Entrez Gene: LDOC1 leucine zipper, down-regulated in cancer 1".
9. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.

Further reading

• Nagasaki K, Schem C, von Kaisenberg C, Biallek M, Rösel F, Jonat W, Maass N (Jul 2003). "Leucine-zipper protein, LDOC1, inhibits NF-kappaB activation and sensitizes pancreatic cancer cells to apoptosis". International Journal of Cancer. 105 (4): 454–8. doi: 10.1002/ijc.11122 . PMID   12712434.
• Chih DY, Park DJ, Gross M, Idos G, Vuong PT, Hirama T, Chumakov AM, Said J, Koeffler HP (Dec 2004). "Protein partners of C/EBPepsilon". Experimental Hematology. 32 (12): 1173–81. doi: 10.1016/j.exphem.2004.08.014 . PMID   15588942.
• Inoue M, Takahashi K, Niide O, Shibata M, Fukuzawa M, Ra C (Jan 2005). "LDOC1, a novel MZF-1-interacting protein, induces apoptosis". FEBS Letters. 579 (3): 604–8. doi: 10.1016/j.febslet.2004.12.030 . PMID   15670815.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.