ACIN1

ACIN1
Identifiers
Aliases	ACIN1 , ACINUS, ACN, fSAP152, apoptotic chromatin condensation inducer 1
External IDs	OMIM: 604562; MGI: 1891824; HomoloGene: 22853; GeneCards: ACIN1; OMA:ACIN1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q11.2 Start 23,058,564 bp [1] End 23,095,614 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14|14 C2 Start 54,642,161 bp [2] End 54,686,931 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube right lobe of thyroid gland sural nerve left lobe of thyroid gland right ovary left ovary body of uterus canal of the cervix right adrenal cortex anterior pituitary Top expressed in neural layer of retina tail of embryo ventricular zone genital tubercle yolk sac granulocyte Rostral migratory stream primary visual cortex superior frontal gyrus lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ATPase activity protein binding enzyme binding nucleic acid binding RNA binding Cellular component nuclear speck plasma membrane exon-exon junction complex nucleoplasm nucleolus ASAP complex nucleus cytosol Biological process apoptotic chromosome condensation mRNA processing negative regulation of mRNA splicing, via spliceosome RNA splicing positive regulation of apoptotic process positive regulation of monocyte differentiation erythrocyte differentiation apoptotic process execution phase of apoptosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22985 56215 Ensembl ENSG00000100813 ENSMUSG00000022185 UniProt Q9UKV3 Q9JIX8 RefSeq (mRNA) NM_001164814 NM_001164815 NM_001164816 NM_001164817 NM_014977 NM_001386863 NM_001085472 NM_001085473 NM_001242605 NM_001242606 NM_019567 NM_023190 RefSeq (protein) NP_001158286 NP_001158287 NP_001158288 NP_001158289 NP_055792 NP_001078941 NP_001078942 NP_001229534 NP_001229535 NP_062513 NP_075679 NP_001361699 Location (UCSC) Chr 14: 23.06 – 23.1 Mb Chr 14: 54.64 – 54.69 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Apoptotic chromatin condensation inducer in the nucleus is a protein that in humans is encoded by the ACIN1 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000100813 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022185 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi: 10.1093/dnares/5.3.169 . PMID   9734811.
6. Sahara S, Aoto M, Eguchi Y, Imamoto N, Yoneda Y, Tsujimoto Y (Sep 1999). "Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation". Nature. 401 (6749): 168–73. Bibcode:1999Natur.401..168S. doi:10.1038/43678. PMID   10490026. S2CID   4364282.
7. "Entrez Gene: ACIN1 apoptotic chromatin condensation inducer 1".

External links

• Human ACIN1 genome location and ACIN1 gene details page in the UCSC Genome Browser .

Further reading

• Zermati Y, Garrido C, Amsellem S, et al. (2001). "Caspase activation is required for terminal erythroid differentiation". J. Exp. Med. 193 (2): 247–54. doi:10.1084/jem.193.2.247. PMC   2193347 . PMID   11208865.
• Sordet O, Rébé C, Plenchette S, et al. (2003). "Specific involvement of caspases in the differentiation of monocytes into macrophages". Blood. 100 (13): 4446–53. doi: 10.1182/blood-2002-06-1778 . PMID   12393560.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Shu H, Chen S, Bi Q, et al. (2004). "Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line". Mol. Cell. Proteomics. 3 (3): 279–86. doi: 10.1074/mcp.D300003-MCP200 . PMID   14729942.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi: 10.1016/j.cub.2004.07.051 . PMID   15324660. S2CID   2371325.
• Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID   16083285.
• Hu Y, Yao J, Liu Z, et al. (2005). "Akt phosphorylates acinus and inhibits its proteolytic cleavage, preventing chromatin condensation". EMBO J. 24 (20): 3543–54. doi:10.1038/sj.emboj.7600823. PMC   1276706 . PMID   16177823.
• Joselin AP, Schulze-Osthoff K, Schwerk C (2006). "Loss of Acinus inhibits oligonucleosomal DNA fragmentation but not chromatin condensation during apoptosis". J. Biol. Chem. 281 (18): 12475–84. doi: 10.1074/jbc.M509859200 . PMID   16537548.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983.
• Shu Y, Iijima T, Sun W, et al. (2007). "The ACIN1 gene is hypermethylated in early stage lung adenocarcinoma". Journal of Thoracic Oncology. 1 (2): 160–7. doi:10.1097/01243894-200602000-00010. PMID   17409846.