ACSL6

ACSL6
Identifiers
Aliases	ACSL6 , ACS2, FACL6, LACS 6, LACS2, LACS5, acyl-CoA synthetase long-chain family member 6, acyl-CoA synthetase long chain family member 6
External IDs	OMIM: 604443 MGI: 894291 HomoloGene: 100939 GeneCards: ACSL6
Gene location (Human)
Chr.	Chromosome 5 (human)
End	132,012,243 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	54,364,756 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; pons; ; seminal vesicula; ; Brodmann area 9; ; endothelial cell; ; prefrontal cortex; ; external globus pallidus; ; parietal lobe; ; postcentral gyrus; ; caudate nucleus;
	Top expressed in
	olfactory epithelium; ; retinal pigment epithelium; ; medial vestibular nucleus; ; dorsal tegmental nucleus; ; anterior horn of spinal cord; ; inferior colliculus; ; pontine nuclei; ; superior colliculus; ; lateral geniculate nucleus; ; globus pallidus;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding ; protein homodimerization activity ; ligase activity ; catalytic activity ; enzyme binding ; ATP binding ; decanoate-CoA ligase activity ; long-chain fatty acid-CoA ligase activity ;
Cellular component	organelle membrane ; integral component of membrane ; endoplasmic reticulum membrane ; membrane ; intracellular membrane-bounded organelle ; plasma membrane ; peroxisomal membrane ; peroxisome ; mitochondrial outer membrane ; endoplasmic reticulum ; mitochondrion ;
Biological process	acyl-CoA metabolic process ; lipid metabolism ; fatty acid metabolic process ; long-chain fatty-acyl-CoA biosynthetic process ; metabolism ; long-chain fatty acid metabolic process ; neuroblast proliferation ;
	Sources:Amigo / QuickGO
Orthologs
	23305
	216739
	ENSG00000164398
	ENSMUSG00000020333
	Q9UKU0
	Q91WC3
NM_015256 ; NM_001009185 ; NM_001205247 ; NM_001205248 ; NM_001205250 ;
	NM_001205251
	NM_001033597 ; NM_001033598 ; NM_001033599 ; NM_144823
NP_001009185 ; NP_001192176 ; NP_001192177 ; NP_001192179 ; NP_001192180 ;
	NP_056071
	NP_001028769 ; NP_001028770 ; NP_001028771 ; NP_659072
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated July 23, 2023

Acyl-CoA synthetase long-chain family member 6 is an enzyme that in humans is encoded by the ACSL6 gene.^[5]^[6]^[7] Long-chain acyl-CoA synthetases such as ACSL6, catalyze the formation of acyl-CoA from fatty acids, ATP, and CoA.^[6]

Structure

The ACSL6 gene is located on the 5th chromosome, with its specific location being 5q31.1. The gene contains 23 exons.^[5] ACSL6 encodes a 77.7 kDa protein that is composed of 697 amino acids; 10 peptides have been observed through mass spectrometry data.^[8]^[9]

Related Research Articles

The long chain fatty acyl-CoA ligase is an enzyme of the ligase family that activates the oxidation of complex fatty acids. Long chain fatty acyl-CoA synthetase catalyzes the formation of fatty acyl-CoA by a two-step process proceeding through an adenylated intermediate. The enzyme catalyzes the following reaction,

Acyl-CoA-binding protein in humans belongs to the family of Acyl-CoA-binding proteins.

Peroxisomal acyl-coenzyme A oxidase 1 is an enzyme that in humans is encoded by the ACOX1 gene.

Long-chain-fatty-acid—CoA ligase 1 is an enzyme that in humans is encoded by the ACSL1 gene.

Long-chain-fatty-acid—CoA ligase 5 is an enzyme that in humans is encoded by the ACSL5 gene.

Long-chain-fatty-acid—CoA ligase 3 is an enzyme that in humans is encoded by the ACSL3 gene.

Fatty acid desaturase 1 is an enzyme that in humans is encoded by the FADS1 gene.

Long-chain-fatty-acid—CoA ligase 4 is an enzyme that in humans is encoded by the ACSL4 gene.

Very long-chain acyl-CoA synthetase is an enzyme that in humans is encoded by the SLC27A2 gene.

Cytosolic acyl coenzyme A thioester hydrolase is an enzyme that in humans is encoded by the ACOT7 gene.

Long-chain fatty acid transport protein 4 is a protein that in humans is encoded by the SLC27A4 gene. This membrane protein is also called FATP4 or ACSVL5. The purified protein shows enzyme activity, esterifying long and very long chain fatty acids with Coenzyme A. It is debated whether it is also a fatty acid transporter at the plasma membrane.

Acyl-CoA Synthetase, Bubblegum Family, member 1 (ACSBG1) is an enzyme that in humans is encoded by the ACSBG1 gene.

Acyl-coenzyme A thioesterase 11 also known as StAR-related lipid transfer protein 14 (STARD14) is an enzyme that in humans is encoded by the ACOT11 gene. This gene encodes a protein with acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates which relies on its StAR-related lipid transfer domain. Expression of a similar murine protein in brown adipose tissue is induced by cold exposure and repressed by warmth. Expression of the mouse protein has been associated with obesity, with higher expression found in obesity-resistant mice compared with obesity-prone mice. Alternative splicing results in two transcript variants encoding different isoforms.

Bile acyl-CoA synthetase is an enzyme that in humans is encoded by the SLC27A5 gene.

Long-chain fatty acid transport protein 6 is a protein that in humans is encoded by the SLC27A6 gene.

(See also: List of proteins in the human body)

Rap guanine nucleotide exchange factor 6 is a protein that in humans is encoded by the RAPGEF6 gene.

Long-chain fatty acid transport protein 3 is a protein that in humans is encoded by the SLC27A3 gene.

Acyl-CoA thioesterase 13 is a protein that in humans is encoded by the ACOT13 gene. This gene encodes a member of the thioesterase superfamily. In humans, the protein co-localizes with microtubules and is essential for sustained cell proliferation.

Acyl-CoA thioesterase 1 is a protein that in humans is encoded by the ACOT1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000164398 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020333 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: acyl-CoA synthetase long-chain family member 6".
1 2 Malhotra KT, Malhotra K, Lubin BH, Kuypers FA (November 1999). "Identification and molecular characterization of acyl-CoA synthetase in human erythrocytes and erythroid precursors". Biochem. J. 344 Pt 1 (Pt 1): 135–43. doi:10.1042/0264-6021:3440135. PMC 1220623 . PMID 10548543.
↑ Yagasaki F, Jinnai I, Yoshida S, Yokoyama Y, Matsuda A, Kusumoto S, Kobayashi H, Terasaki H, Ohyashiki K, Asou N, Murohashi I, Bessho M, Hirashima K (November 1999). "Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5;12)(q31;p13)". Genes Chromosomes Cancer. 26 (3): 192–202. doi: 10.1002/(SICI)1098-2264(199911)26:3<192::AID-GCC2>3.0.CO;2-E . PMID 10502316.
↑ ]Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya I, Liem D, Meyer D, Odeberg J, Fang C, Lu HJ, Xu T, Weiss J, Duan H, Uhlen M, Yates JR, Apweiler R, Ge J, Hermjakob H, Ping P (Oct 2013). "Integration of cardiac proteome biology and medicine by a specialized knowledgebase". Circulation Research. 113 (9): 1043–53. doi:10.1161/CIRCRESAHA.113.301151. PMC 4076475 . PMID 23965338.
↑ "Long-chain-fatty-acid--CoA ligase 6". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB).^{[ permanent dead link ]}

External links

Human ACSL6 genome location and ACSL6 gene details page in the UCSC Genome Browser .

Soupene E, Kuypers FA (2006). "Multiple erythroid isoforms of human long-chain acyl-CoA synthetases are produced by switch of the fatty acid gate domains". BMC Mol. Biol. 7: 21. doi:10.1186/1471-2199-7-21. PMC 1543647 . PMID 16834775.
Kang H, Lee SK, Kim MH, et al. (2009). "Acyl-CoA synthetase long-chain family member 6 is associated with premature ovarian failure". Fertil. Steril. 91 (4 Suppl): 1339–43. doi: 10.1016/j.fertnstert.2008.03.035 . PMID 18555221.
Nagase T, Ishikawa K, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi: 10.1093/dnares/5.6.355 . PMID 10048485.
Ma J, Dempsey AA, Stamatiou D, et al. (2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects". Atherosclerosis. 191 (1): 63–72. doi:10.1016/j.atherosclerosis.2006.05.032. PMID 16806233.
Mashek DG, Bornfeldt KE, Coleman RA, et al. (2004). "Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family". J. Lipid Res. 45 (10): 1958–61. doi: 10.1194/jlr.E400002-JLR200 . PMID 15292367.
Murati A, Adélaïde J, Gelsi-Boyer V, et al. (2006). "t(5;12)(q23-31;p13) with ETV6-ACSL6 gene fusion in polycythemia vera". Leukemia. 20 (6): 1175–8. doi: 10.1038/sj.leu.2404194 . PMID 16572202.
Luo XJ, Diao HB, Wang JK, et al. (2008). "Association of haplotypes spanning PDZ-GEF2, LOC728637 and ACSL6 with schizophrenia in Han Chinese". J. Med. Genet. 45 (12): 818–26. doi:10.1136/jmg.2008.060657. PMID 18718982. S2CID 206999081.
Chen X, Wang X, Hossain S, et al. (2006). "Haplotypes spanning SPEC2, PDZ-GEF2 and ACSL6 genes are associated with schizophrenia". Hum. Mol. Genet. 15 (22): 3329–42. doi: 10.1093/hmg/ddl409 . PMID 17030554.
Denoeud F, Kapranov P, Ucla C, et al. (2007). "Prominent use of distal 5′ transcription start sites and discovery of a large number of additional exons in ENCODE regions". Genome Res. 17 (6): 746–59. doi:10.1101/gr.5660607. PMC 1891335 . PMID 17567994.
Edwards TL, Wang X, Chen Q, et al. (2008). "Interaction between Interleukin 3 and Dystrobrevin-Binding Protein 1 in Schizophrenia". Schizophr. Res. 106 (2–3): 208–17. doi:10.1016/j.schres.2008.07.022. PMC 2746913 . PMID 18804346.
Chowdari KV, Northup A, Pless L, et al. (2007). "DNA pooling: a comprehensive, multi-stage association analysis of ACSL6 and SIRT5 polymorphisms in schizophrenia". Genes Brain Behav. 6 (3): 229–39. doi: 10.1111/j.1601-183X.2006.00251.x . PMID 16827919. S2CID 44288193.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Wang L, McDonnell SK, Hebbring SJ, et al. (2008). "Polymorphisms in mitochondrial genes and prostate cancer risk". Cancer Epidemiol. Biomarkers Prev. 17 (12): 3558–66. doi:10.1158/1055-9965.EPI-08-0434. PMC 2750891 . PMID 19064571.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000164398 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020333 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: acyl-CoA synthetase long-chain family member 6".

[pmid10548543-6] 1 2 Malhotra KT, Malhotra K, Lubin BH, Kuypers FA (November 1999). "Identification and molecular characterization of acyl-CoA synthetase in human erythrocytes and erythroid precursors". Biochem. J. 344 Pt 1 (Pt 1): 135–43. doi:10.1042/0264-6021:3440135. PMC 1220623 . PMID 10548543.

[pmid10502316-7] Yagasaki F, Jinnai I, Yoshida S, Yokoyama Y, Matsuda A, Kusumoto S, Kobayashi H, Terasaki H, Ohyashiki K, Asou N, Murohashi I, Bessho M, Hirashima K (November 1999). "Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5;12)(q31;p13)". Genes Chromosomes Cancer. 26 (3): 192–202. doi: 10.1002/(SICI)1098-2264(199911)26:3<192::AID-GCC2>3.0.CO;2-E . PMID 10502316.

[COPaKB-8] ]Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya I, Liem D, Meyer D, Odeberg J, Fang C, Lu HJ, Xu T, Weiss J, Duan H, Uhlen M, Yates JR, Apweiler R, Ge J, Hermjakob H, Ping P (Oct 2013). "Integration of cardiac proteome biology and medicine by a specialized knowledgebase". Circulation Research. 113 (9): 1043–53. doi:10.1161/CIRCRESAHA.113.301151. PMC 4076475 . PMID 23965338.

[url_COPaKB-9] "Long-chain-fatty-acid--CoA ligase 6". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB).^{[ permanent dead link ]}

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ACSL6

Contents

Structure

Related Research Articles

References

External links

Further reading