ACSL6

ACSL6
Identifiers
Aliases	ACSL6 , ACS2, FACL6, LACS 6, LACS2, LACS5, acyl-CoA synthetase long-chain family member 6, acyl-CoA synthetase long chain family member 6
External IDs	OMIM: 604443; MGI: 894291; HomoloGene: 100939; GeneCards: ACSL6; OMA:ACSL6 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q31.1 Start 131,949,973 bp [1] End 132,012,243 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11 B1.3|11 32.13 cM Start 54,303,798 bp [2] End 54,364,756 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lateral nuclear group of thalamus Brodmann area 23 primary visual cortex right hemisphere of cerebellum Pons seminal vesicula Brodmann area 9 endothelial cell right frontal lobe left testis Top expressed in olfactory epithelium retinal pigment epithelium deep cerebellar nuclei central gray substance of midbrain medial vestibular nucleus dorsal tegmental nucleus anterior horn of spinal cord inferior colliculi pontine nuclei neural layer of retina More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding protein homodimerization activity ligase activity catalytic activity enzyme binding ATP binding decanoate-CoA ligase activity long-chain fatty acid-CoA ligase activity Cellular component organelle membrane integral component of membrane endoplasmic reticulum membrane membrane intracellular membrane-bounded organelle plasma membrane peroxisomal membrane peroxisome mitochondrial outer membrane endoplasmic reticulum mitochondrion Biological process acyl-CoA metabolic process lipid metabolism fatty acid metabolic process long-chain fatty-acyl-CoA biosynthetic process metabolism long-chain fatty acid metabolic process neuroblast proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23305 216739 Ensembl ENSG00000164398 ENSMUSG00000020333 UniProt Q9UKU0 Q91WC3 RefSeq (mRNA) NM_015256 NM_001009185 NM_001205247 NM_001205248 NM_001205250 NM_001205251 NM_001033597 NM_001033598 NM_001033599 NM_144823 RefSeq (protein) NP_001009185 NP_001192176 NP_001192177 NP_001192179 NP_001192180 NP_056071 NP_001028769 NP_001028770 NP_001028771 NP_659072 Location (UCSC) Chr 5: 131.95 – 132.01 Mb Chr 11: 54.3 – 54.36 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Acyl-CoA synthetase long-chain family member 6 is an enzyme that in humans is encoded by the ACSL6 gene. ^{[5] [6] [7]} Long-chain acyl-CoA synthetases such as ACSL6, catalyze the formation of acyl-CoA from fatty acids, ATP, and CoA. ^[6]

Structure

The ACSL6 gene is located on the 5th chromosome, with its specific location being 5q31.1. The gene contains 23 exons. ^[5] ACSL6 encodes a 77.7 kDa protein that is composed of 697 amino acids; 10 peptides have been observed through mass spectrometry data. ^{[8] [9]}

References

1. GRCh38: Ensembl release 89: ENSG00000164398 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020333 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: acyl-CoA synthetase long-chain family member 6".
6. Malhotra KT, Malhotra K, Lubin BH, Kuypers FA (November 1999). "Identification and molecular characterization of acyl-CoA synthetase in human erythrocytes and erythroid precursors". Biochem. J. 344 Pt 1 (Pt 1): 135–43. doi:10.1042/0264-6021:3440135. PMC   1220623 . PMID   10548543.
7. Yagasaki F, Jinnai I, Yoshida S, Yokoyama Y, Matsuda A, Kusumoto S, Kobayashi H, Terasaki H, Ohyashiki K, Asou N, Murohashi I, Bessho M, Hirashima K (November 1999). "Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5;12)(q31;p13)". Genes Chromosomes Cancer. 26 (3): 192–202. doi: 10.1002/(SICI)1098-2264(199911)26:3<192::AID-GCC2>3.0.CO;2-E . PMID   10502316.
8. ]Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya I, Liem D, Meyer D, Odeberg J, Fang C, Lu HJ, Xu T, Weiss J, Duan H, Uhlen M, Yates JR, Apweiler R, Ge J, Hermjakob H, Ping P (Oct 2013). "Integration of cardiac proteome biology and medicine by a specialized knowledgebase". Circulation Research. 113 (9): 1043–53. doi:10.1161/CIRCRESAHA.113.301151. PMC   4076475 . PMID   23965338.
9. "Long-chain-fatty-acid--CoA ligase 6". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB).^{[ permanent dead link ‍]}

External links

• Human ACSL6 genome location and ACSL6 gene details page in the UCSC Genome Browser .

Further reading

• Soupene E, Kuypers FA (2006). "Multiple erythroid isoforms of human long-chain acyl-CoA synthetases are produced by switch of the fatty acid gate domains". BMC Mol. Biol. 7: 21. doi: 10.1186/1471-2199-7-21 . PMC   1543647 . PMID   16834775.
• Kang H, Lee SK, Kim MH, et al. (2009). "Acyl-CoA synthetase long-chain family member 6 is associated with premature ovarian failure". Fertil. Steril. 91 (4 Suppl): 1339–43. doi: 10.1016/j.fertnstert.2008.03.035 . PMID   18555221.
• Nagase T, Ishikawa K, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi: 10.1093/dnares/5.6.355 . PMID   10048485.
• Ma J, Dempsey AA, Stamatiou D, et al. (2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects". Atherosclerosis. 191 (1): 63–72. doi:10.1016/j.atherosclerosis.2006.05.032. PMID   16806233.
• Mashek DG, Bornfeldt KE, Coleman RA, et al. (2004). "Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family". J. Lipid Res. 45 (10): 1958–61. doi: 10.1194/jlr.E400002-JLR200 . PMID   15292367.
• Murati A, Adélaïde J, Gelsi-Boyer V, et al. (2006). "t(5;12)(q23-31;p13) with ETV6-ACSL6 gene fusion in polycythemia vera". Leukemia. 20 (6): 1175–8. doi: 10.1038/sj.leu.2404194 . PMID   16572202.
• Luo XJ, Diao HB, Wang JK, et al. (2008). "Association of haplotypes spanning PDZ-GEF2, LOC728637 and ACSL6 with schizophrenia in Han Chinese". J. Med. Genet. 45 (12): 818–26. doi:10.1136/jmg.2008.060657. PMID   18718982. S2CID   206999081.
• Chen X, Wang X, Hossain S, et al. (2006). "Haplotypes spanning SPEC2, PDZ-GEF2 and ACSL6 genes are associated with schizophrenia". Hum. Mol. Genet. 15 (22): 3329–42. doi: 10.1093/hmg/ddl409 . PMID   17030554.
• Denoeud F, Kapranov P, Ucla C, et al. (2007). "Prominent use of distal 5′ transcription start sites and discovery of a large number of additional exons in ENCODE regions". Genome Res. 17 (6): 746–59. doi:10.1101/gr.5660607. PMC   1891335 . PMID   17567994.
• Edwards TL, Wang X, Chen Q, et al. (2008). "Interaction between Interleukin 3 and Dystrobrevin-Binding Protein 1 in Schizophrenia". Schizophr. Res. 106 (2–3): 208–17. doi:10.1016/j.schres.2008.07.022. PMC   2746913 . PMID   18804346.
• Chowdari KV, Northup A, Pless L, et al. (2007). "DNA pooling: a comprehensive, multi-stage association analysis of ACSL6 and SIRT5 polymorphisms in schizophrenia". Genes Brain Behav. 6 (3): 229–39. doi: 10.1111/j.1601-183X.2006.00251.x . PMID   16827919. S2CID   44288193.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Wang L, McDonnell SK, Hebbring SJ, et al. (2008). "Polymorphisms in mitochondrial genes and prostate cancer risk". Cancer Epidemiol. Biomarkers Prev. 17 (12): 3558–66. doi:10.1158/1055-9965.EPI-08-0434. PMC   2750891 . PMID   19064571.