ACTR3B

ACTR3B
Identifiers
Aliases	ACTR3B , ARP11, ARP3BETA, ARP3 actin-related protein 3 homolog B (yeast)
External IDs	MGI: 2661120 HomoloGene: 4180 GeneCards: ACTR3B
Gene location (Mouse) Chr. Chromosome 5 (mouse) [1] Band 5|5 B1 Start 25,964,995 bp [1] End 26,055,686 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) n/a Top expressed in hippocampus proper olfactory tubercle dentate gyrus visual cortex superior frontal gyrus piriform cortex interventricular septum prefrontal cortex primary motor cortex nucleus accumbens BioGPS More reference expression data
Gene ontology Molecular function ATP binding nucleotide binding actin binding molecular function actin filament binding Cellular component Arp2/3 protein complex cell projection cytoplasm cytoskeleton extracellular exosome Biological process actin filament organization Arp2/3 complex-mediated actin nucleation biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57180 242894 Ensembl ENSG00000133627 ENSMUSG00000056367 UniProt Q9P1U1 Q641P0 RefSeq (mRNA) NM_001040135 NM_020445 NM_001004365 NM_001310504 RefSeq (protein) NP_001035225 NP_065178 NP_001337869 NP_001337870 NP_001337871 NP_001337872 NP_001337873 NP_001337874 NP_001337875 NP_001004365 NP_001297433 Location (UCSC) n/a Chr 5: 25.96 – 26.06 Mb PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Actin-related protein 3B also known as ARP3-beta is a protein that in humans is encoded by the ACTR3B gene. ^[4] Pseudogenes of this gene are located on chromosomes 2, 4, 10, 16, 22 and Y. Alternative splicing results in multiple transcript variants and protein isoforms. ^[4]

Function

This gene encodes a member of the actin-related proteins (ARP), which form multiprotein complexes and share 35-55% amino acid identity with conventional actin. The protein encoded by this gene may have a regulatory role in the actin cytoskeleton and induce cell-shape change and motility. ^[4]

References

1. GRCm38: Ensembl release 89: ENSMUSG00000056367 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: ACTR3B ARP3 actin-related protein 3 homolog B (yeast)".

External links

• Human ACTR3B genome location and ACTR3B gene details page in the UCSC Genome Browser .

Further reading

• Machesky LM, Gould KL (Feb 1999). "The Arp2/3 complex: a multifunctional actin organizer". Current Opinion in Cell Biology. 11 (1): 117–21. doi:10.1016/S0955-0674(99)80014-3. PMID   10047519.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Shindo-Okada N, Iigo M (Dec 2003). "Expression of the Arp11 gene suppresses the tumorigenicity of PC-14 human lung adenocarcinoma cells". Biochemical and Biophysical Research Communications. 312 (4): 889–96. doi:10.1016/j.bbrc.2003.10.200. PMID   14651955.
• Shindo-Okada N, Shimizu K (Jan 2001). "Isolation of a novel actin-related gene expressed in low-metastatic PC-14 human lung adenocarcinoma". Biochemical and Biophysical Research Communications. 280 (1): 61–7. doi:10.1006/bbrc.2000.4059. PMID   11162478.
• Jay P, Bergé-Lefranc JL, Massacrier A, Roessler E, Wallis D, Muenke M, Gastaldi M, Taviaux S, Cau P, Berta P (May 2000). "ARP3beta, the gene encoding a new human actin-related protein, is alternatively spliced and predominantly expressed in brain neuronal cells". European Journal of Biochemistry. 267 (10): 2921–8. doi: 10.1046/j.1432-1327.2000.01306.x . PMID   10806390.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.