ADCK3

This article is about a protein. It is not to be confused with ADCK.

COQ8A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4PED
Identifiers
Aliases	COQ8A , ARCA2, CABC1, COQ10D4, COQ8, SCAR9, ADCK3, aarF domain containing kinase 3, coenzyme Q8A
External IDs	OMIM: 606980 MGI: 1914676 HomoloGene: 11345 GeneCards: COQ8A
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q42.13 Start 226,940,286 bp [1] End 226,987,544 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 H4 Start 179,992,803 bp [2] End 180,027,167 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle skeletal muscle tissue body of pancreas left ventricle Right adrenal gland Left adrenal gland fundus body of stomach right lobe of liver cerebellar hemisphere Top expressed in extraocular muscle interventricular septum soleus muscle digastric muscle sternocleidomastoid muscle tibialis anterior muscle temporal muscle masseter muscle myocardium of ventricle intercostal muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding ADP binding protein binding ATP binding protein kinase activity kinase activity Cellular component integral component of membrane mitochondrion membrane extrinsic component of mitochondrial inner membrane Biological process ubiquinone biosynthetic process protein phosphorylation phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56997 67426 Ensembl ENSG00000163050 ENSMUSG00000026489 UniProt Q8NI60 Q60936 RefSeq (mRNA) NM_020247 NM_001163290 NM_023341 NM_001359268 NM_001359269 RefSeq (protein) NP_064632 NP_001156762 NP_075830 NP_001346197 NP_001346198 Location (UCSC) Chr 1: 226.94 – 226.99 Mb Chr 1: 179.99 – 180.03 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

aarF domain containing kinase 3 is a protein that in humans is encoded by the ADCK3 gene. ^[5]

This gene encodes a mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane protein complex in the respiratory chain. It is not related to the family of ABC transporter proteins. Expression of this gene is induced by the tumor suppressor p53 and in response to DNA damage, and inhibiting its expression partially suppresses p53-induced apoptosis. Alternatively spliced transcript variants have been found; however, their full-length nature has not been determined. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000163050 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026489 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: ADCK3 aarF domain containing kinase 3".

External links

• Human ADCK3 genome location and ADCK3 gene details page in the UCSC Genome Browser .

Further reading

• Lagier-Tourenne C, Tazir M, López LC, et al. (2008). "ADCK3, an ancestral kinase, is mutated in a form of recessive ataxia associated with coenzyme Q10 deficiency". Am. J. Hum. Genet. 82 (3): 661–72. doi:10.1016/j.ajhg.2007.12.024. PMC   2427193 . PMID   18319074.
• Mollet J, Delahodde A, Serre V, et al. (2008). "CABC1 gene mutations cause ubiquinone deficiency with cerebellar ataxia and seizures". Am. J. Hum. Genet. 82 (3): 623–30. doi:10.1016/j.ajhg.2007.12.022. PMC   2427298 . PMID   18319072.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi: 10.1073/pnas.0404089101 . PMC   524842 . PMID   15498874.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Iiizumi M, Arakawa H, Mori T, et al. (2002). "Isolation of a novel gene, CABC1, encoding a mitochondrial protein that is highly homologous to yeast activity of bc1 complex". Cancer Res. 62 (5): 1246–50. PMID   11888884.