AFAP1

AFAP1
Identifiers
Aliases	AFAP1 , AFAP, AFAP-110, AFAP110, actin filament associated protein 1
External IDs	OMIM: 608252 MGI: 1917542 HomoloGene: 11009 GeneCards: AFAP1
Gene location (Human)
Chr.	Chromosome 4 (human)
End	7,939,926 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	36,161,267 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; sural nerve; ; ganglionic eminence; ; popliteal artery; ; right coronary artery; ; ascending aorta; ; germinal epithelium; ; rectum; ; left coronary artery; ; smooth muscle tissue;
	Top expressed in
	pineal gland; ; iris; ; belly cord; ; aorta; ; superior cervical ganglion; ; otolith organ; ; calvaria; ; utricle; ; atrium; ; stria vascularis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	actin binding ; SH3 domain binding ; SH2 domain binding ;
Cellular component	cytoplasm ; cytoskeleton ; focal adhesion ; cytosol ; actin cytoskeleton ;
Biological process	regulation of signal transduction ; regulation of cytoskeleton organization ;
	Sources:Amigo / QuickGO
Orthologs
	60312
	70292
	ENSG00000196526
	ENSMUSG00000029094
	Q8N556
	Q80YS6
	NM_001134647 ; NM_021638 ; NM_198595 ; NM_001371090 ; NM_001371091 Contents References ; External links ; Further reading ;
	NM_027373
	NP_001128119 ; NP_940997 ; NP_001358019 ; NP_001358020
	NP_081649 ; NP_001390348 ; NP_001390349 ; NP_001390350
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 08, 2024

Actin filament-associated protein 1 is a protein that in humans is encoded by the AFAP1 gene.^[5]^[6]^[7]^[8]

The protein encoded by this gene is a Src binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling proteins to actin filaments. Two alternative transcripts encoding the same protein have been identified.^[8]

Related Research Articles

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Scinderin is a protein that in humans is encoded by the SCIN gene. Scinderin is an actin severing protein belonging to the gelsolin superfamily. It was discovered in Dr. Trifaro's laboratory at the University of Ottawa, Canada. Secretory tissues are rich in scinderin. In these tissues scinderin, a calcium dependent protein, regulates cortical actin networks. Normally secretory vesicles are excluded from release sites on the plasma membrane by the presence of a cortical actin filament network. During cell stimulation, calcium channels open allowing calcium ions to enter the secretory cell. Increase in intracellular calcium activates scinderin with the consequent actin filament severing and local dissociation of actin filament networks. This allows the movement of secretory vesicles to release sites on the plasma membrane.

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XB130 is a cytosolic adaptor protein and signal transduction mediator. XB130 regulates cell proliferation, cell survival, cell motility and gene expression. XB130 is highly similar to AFAP and is thus known as actin filament associated protein 1-like 2 (AFAP1L2). XB130 is a substrate and regulator of multiple tyrosine kinase-mediated signaling. XB130 is highly expressed in the thyroid and spleen.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000196526 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029094 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Qian Y, Gatesman AS, Baisden JM, Zot HG, Cherezova L, Qazi I, Mazloum N, Lee MY, Guappone-Koay A, Flynn DC (Feb 2004). "Analysis of the role of the leucine zipper motif in regulating the ability of AFAP-110 to alter actin filament integrity". J Cell Biochem. 91 (3): 602–20. doi:10.1002/jcb.10725. PMID 14755689. S2CID 38130241.
↑ Baisden JM, Gatesman AS, Cherezova L, Jiang BH, Flynn DC (Oct 2001). "The intrinsic ability of AFAP-110 to alter actin filament integrity is linked with its ability to also activate cellular tyrosine kinases". Oncogene. 20 (45): 6607–16. doi:10.1038/sj.onc.1204802. PMID 11641786. S2CID 21926408.
↑ Baisden JM, Qian Y, Zot HM, Flynn DC (Oct 2001). "The actin filament-associated protein AFAP-110 is an adaptor protein that modulates changes in actin filament integrity". Oncogene. 20 (44): 6435–47. doi: 10.1038/sj.onc.1204784 . PMID 11607843.
1 2 "Entrez Gene: AFAP1 actin filament associated protein 1".

External links

Human AFAP1 genome location and AFAP1 gene details page in the UCSC Genome Browser .

Ishida Y, Hadano S, Nagayama T, et al. (1995). "Isolation and characterization of 21 novel expressed DNA sequences from the distal region of human chromosome 4p". Genomics. 22 (2): 302–12. doi:10.1006/geno.1994.1388. PMID 7545969.
Qian Y, Baisden JM, Westin EH, et al. (1998). "Src can regulate carboxy terminal interactions with AFAP-110, which influence self-association, cell localization and actin filament integrity". Oncogene. 16 (17): 2185–95. doi:10.1038/sj.onc.1201753. PMID 9619827. S2CID 28373925.
Guappone AC, Weimer T, Flynn DC (1998). "Formation of a stable src-AFAP-110 complex through either an amino-terminal or a carboxy-terminal SH2-binding motif". Mol. Carcinog. 22 (2): 110–9. doi:10.1002/(SICI)1098-2744(199806)22:2<110::AID-MC6>3.0.CO;2-Q. PMID 9655255. S2CID 10461528.
Qian Y, Baisden JM, Zot HG, et al. (2000). "The carboxy terminus of AFAP-110 modulates direct interactions with actin filaments and regulates its ability to alter actin filament integrity and induce lamellipodia formation". Exp. Cell Res. 255 (1): 102–13. doi:10.1006/excr.1999.4795. PMID 10666339.
Qian Y, Baisden JM, Cherezova L, et al. (2003). "PC phosphorylation increases the ability of AFAP-110 to cross-link actin filaments". Mol. Biol. Cell. 13 (7): 2311–22. doi:10.1091/mbc.E01-12-0148. PMC 117315 . PMID 12134071.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi: 10.1074/mcp.M400085-MCP200 . PMID 15345747.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560.
Dorfleutner A, Stehlik C, Zhang J, et al. (2007). "AFAP-110 is required for actin stress fiber formation and cell adhesion in MDA-MB-231 breast cancer cells". J. Cell. Physiol. 213 (3): 740–9. CiteSeerX 10.1.1.636.3591 . doi:10.1002/jcp.21143. PMID 17520695. S2CID 15344259.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000196526 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029094 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid14755689-5] Qian Y, Gatesman AS, Baisden JM, Zot HG, Cherezova L, Qazi I, Mazloum N, Lee MY, Guappone-Koay A, Flynn DC (Feb 2004). "Analysis of the role of the leucine zipper motif in regulating the ability of AFAP-110 to alter actin filament integrity". J Cell Biochem. 91 (3): 602–20. doi:10.1002/jcb.10725. PMID 14755689. S2CID 38130241.

[pmid11641786-6] Baisden JM, Gatesman AS, Cherezova L, Jiang BH, Flynn DC (Oct 2001). "The intrinsic ability of AFAP-110 to alter actin filament integrity is linked with its ability to also activate cellular tyrosine kinases". Oncogene. 20 (45): 6607–16. doi:10.1038/sj.onc.1204802. PMID 11641786. S2CID 21926408.

[pmid11607843-7] Baisden JM, Qian Y, Zot HM, Flynn DC (Oct 2001). "The actin filament-associated protein AFAP-110 is an adaptor protein that modulates changes in actin filament integrity". Oncogene. 20 (44): 6435–47. doi: 10.1038/sj.onc.1204784 . PMID 11607843.

[entrez-8] 1 2 "Entrez Gene: AFAP1 actin filament associated protein 1".

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AFAP1

Contents

Related Research Articles

References

External links

Further reading