AIM1

CRYBG1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3CW3, 2DAD,%%s2DAD
Identifiers
Aliases	CRYBG1 , ST4, AIM1, absent in melanoma 1, crystallin beta-gamma domain containing 1
External IDs	OMIM: 601797; MGI: 109544; HomoloGene: 18168; GeneCards: CRYBG1; OMA:CRYBG1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6q21 Start 106,360,717 bp [1] End 106,572,017 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10 B2|10 23.14 cM Start 43,826,632 bp [2] End 44,024,849 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of thigh oral cavity gums pancreatic ductal cell gingival epithelium mucosa of pharynx placenta vulva palpebral conjunctiva skin of hip Top expressed in corneal stroma Ileal epithelium superior surface of tongue esophagus lip skin of back transitional epithelium of urinary bladder skin of external ear lactiferous gland zygote More reference expression data BioGPS More reference expression data
Gene ontology Molecular function carbohydrate binding molecular function Cellular component cellular component Biological process biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 202 11630 Ensembl ENSG00000112297 ENSMUSG00000019866 UniProt Q9Y4K1 Q96QW7 n/a RefSeq (mRNA) NM_001624 NM_001371242 NM_172393 NM_001368305 NM_001368306 RefSeq (protein) NP_001615 NP_001358171 n/a Location (UCSC) Chr 6: 106.36 – 106.57 Mb Chr 10: 43.83 – 44.02 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Absent in melanoma 1 protein is a protein that in humans is encoded by the AIM1 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000112297 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019866 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Millikin D, Meese E, Vogelstein B, Witkowski C, Trent J (Nov 1991). "Loss of heterozygosity for loci on the long arm of chromosome 6 in human malignant melanoma". Cancer Research. 51 (20): 5449–53. PMID   1680551.
6. Rajini B, Graham C, Wistow G, Sharma Y (Apr 2003). "Stability, homodimerization, and calcium-binding properties of a single, variant betagamma-crystallin domain of the protein absent in melanoma 1 (AIM1)". Biochemistry. 42 (15): 4552–9. doi:10.1021/bi027384l. PMID   12693952.
7. "Entrez Gene: AIM1 absent in melanoma 1".

External links

• Human AIM1 genome location and AIM1 gene details page in the UCSC Genome Browser .
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Beta/gamma crystallin domain-containing protein 1 (AIM1)

Further reading

• Ray ME, Su YA, Meltzer PS, Trent JM (1996). "Isolation and characterization of genes associated with chromosome-6 mediated tumor suppression in human malignant melanoma". Oncogene. 12 (12): 2527–33. PMID   8700511.
• Ray ME, Wistow G, Su YA, et al. (1997). "AIM1, a novel non-lens member of the betagamma-crystallin superfamily, is associated with the control of tumorigenicity in human malignant melanoma". Proceedings of the National Academy of Sciences of the United States of America. 94 (7): 3229–34. Bibcode:1997PNAS...94.3229R. doi: 10.1073/pnas.94.7.3229 . PMC   20351 . PMID   9096375.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi: 10.1073/pnas.97.7.3491 . PMC   16267 . PMID   10737800.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi: 10.1038/nature02055 . PMID   14574404.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nature Genetics. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Aravind P, Rajini B, Sharma Y, Sankaranarayanan R (2006). "Crystallization and preliminary X-ray crystallographic investigations on a betagamma-crystallin domain of absent in melanoma 1 (AIM1), a protein from Homo sapiens". Acta Crystallographica Section F. 62 (Pt 3): 282–4. doi:10.1107/S1744309106005380. PMC   2197174 . PMID   16511323.