AKAP1

AKAP1
Identifiers
Aliases	AKAP1 , AKAP, AKAP121, AKAP149, AKAP84, D-PPP1R43, PRKA1, SAKAP84, TDRD17, A-kinase anchoring protein 1
External IDs	OMIM: 602449 MGI: 104729 HomoloGene: 31165 GeneCards: AKAP1
Gene location (Human)
Chr.	Chromosome 17 (human)
End	57,121,346 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	88,755,412 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; sperm; ; body of tongue; ; thoracic diaphragm; ; cardia; ; saphenous vein; ; vena cava; ; biceps brachii; ; vastus lateralis muscle; ; renal medulla;
	Top expressed in
	seminiferous tubule; ; spermatid; ; brown adipose tissue; ; digastric muscle; ; right ventricle; ; soleus muscle; ; extraocular muscle; ; thoracic diaphragm; ; secondary oocyte; ; interventricular septum;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding ; protein kinase A regulatory subunit binding ; nucleic acid binding ; RNA binding ;
Cellular component	integral component of membrane ; mitochondrion ; mitochondrial outer membrane ; membrane ; cytosol ;
Biological process	regulation of protein kinase A signaling ; blood coagulation ;
	Sources:Amigo / QuickGO
Orthologs
	8165
	11640
	ENSG00000121057
	ENSMUSG00000018428
	Q92667
	O08715
NM_001242902 ; NM_001242903 ; NM_003488 ; NM_139275 ; NM_001370423 ;
	NM_001370424 ; NM_001370425 ; NM_001370426 ; NM_001370427 Contents Function ; Interactions ; References ; External links ; Further reading ;
	NM_001042541 ; NM_009648
NP_001229831 ; NP_001229832 ; NP_003479 ; NP_001357352 ; NP_001357353 ;
	NP_001357354 ; NP_001357355 ; NP_001357356
	NP_001036006 ; NP_033778
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 12, 2022

A kinase anchor protein 1, mitochondrial is an enzyme that in humans is encoded by the AKAP1 gene.^[5]^[6]^[7]

Function

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins that have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to type I and type II regulatory subunits of PKA and anchors them to the mitochondrion. This protein is speculated to be involved in the cAMP-dependent signal transduction pathway and in directing RNA to a specific cellular compartment.^[7]

Interactions

AKAP1 has been shown to interact with:

Related Research Articles

In cell biology, protein kinase A (PKA) is a family of enzymes whose activity is dependent on cellular levels of cyclic AMP (cAMP). PKA is also known as cAMP-dependent protein kinase. PKA has several functions in the cell, including regulation of glycogen, sugar, and lipid metabolism. It should not be confused with 5'-AMP-activated protein kinase.

The catalytic subunit α of protein kinase A is a key regulatory enzyme that in humans is encoded by the PRKACA gene. This enzyme is responsible for phosphorylating other proteins and substrates, changing their activity. Protein kinase A catalytic subunit is a member of the AGC kinase family, and contributes to the control of cellular processes that include glucose metabolism, cell division, and contextual memory. PKA Cα is part of a larger protein complex that is responsible for controlling when and where proteins are phosphorylated. Defective regulation of PKA holoenzyme activity has been linked to the progression of cardiovascular disease, certain endocrine disorders and cancers.

cAMP-dependent protein kinase type I-alpha regulatory subunit is an enzyme that in humans is encoded by the PRKAR1A gene.

cAMP-dependent protein kinase type II-alpha regulatory subunit is an enzyme that in humans is encoded by the PRKAR2A gene.

cAMP-dependent protein kinase type II-beta regulatory subunit is an enzyme that in humans is encoded by the PRKAR2B gene.

A-kinase anchor protein 13 is a protein that in humans is encoded by the AKAP13 gene. This protein is also called AKAP-Lbc because it encodes the lymphocyte blast crisis (Lbc) oncogene, and ARHGEF13/RhoGEF13 because it contains a guanine nucleotide exchange factor (GEF) domain for the RhoA small GTP-binding protein.

A-kinase anchor protein 5 is a protein that in humans is encoded by the AKAP5 gene.

cAMP-dependent protein kinase catalytic subunit beta is an enzyme that in humans is encoded by the PRKACB gene.

A-kinase anchor protein 9 is a protein that in humans is encoded by the AKAP9 gene. AKAP9 is also known as Centrosome- and Golgi-localized protein kinase N-associated protein (CG-NAP) or AKAP350 or AKAP450

A-kinase anchor protein 12, aka AKAP250, is an enzyme that in humans is encoded by the AKAP12 gene.

cAMP-dependent protein kinase type I-beta regulatory subunit is an enzyme that in humans is encoded by the PRKAR1B gene.

A-kinase anchor protein 8 is an enzyme that, in humans, is encoded by the AKAP8 gene.

cAMP-dependent protein kinase catalytic subunit gamma is an enzyme that in humans is encoded by the PRKACG gene.

A-kinase anchor protein 3 is an enzyme that in humans is encoded by the AKAP3 gene.

A-kinase anchor protein 11 is an enzyme that in humans is encoded by the AKAP11 gene.

A-kinase anchor protein 6 is an enzyme that in humans is encoded by the AKAP6 gene.

C-Myc-binding protein is a protein that in humans is encoded by the MYCBP gene.

A-kinase anchor protein 4 is a scaffold protein that in humans is encoded by the AKAP4 gene. It involves in the intracellular signalling of protein kinase -A. AKAP4 is called as cancer /testis antigen (CTA), it belongs to a class of tumour linked antigens categories by high expression in germ cells and cancer than normal tissues. AKAP4 is not normally expressed in mRNA and protein level in MM cell line.

AMY-1-associating protein expressed in testis 1 is a protein that in humans is encoded by the MAATS1 gene.

The A-kinase anchoring proteins or A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. At least 20 AKAPs have been cloned. There are at least 50 members, often named after their molecular mass.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000121057 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018428 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Trendelenburg G, Hummel M, Riecken EO, Hanski C (Sep 1996). "Molecular characterization of AKAP149, a novel A kinase anchor protein with a KH domain". Biochem Biophys Res Commun. 225 (1): 313–9. doi:10.1006/bbrc.1996.1172. PMID 8769136.
↑ Lin RY, Moss SB, Rubin CS (Jan 1996). "Characterization of S-AKAP84, a novel developmentally regulated A kinase anchor protein of male germ cells". J Biol Chem. 270 (46): 27804–11. doi: 10.1074/jbc.270.46.27804 . PMID 7499250.
1 2 "Entrez Gene: AKAP1 A kinase (PRKA) anchor protein 1".
1 2 Yukitake H, Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H (Nov 2002). "AAT-1, a novel testis-specific AMY-1-binding protein, forms a quaternary complex with AMY-1, A-kinase anchor protein 84, and a regulatory subunit of cAMP-dependent protein kinase and is phosphorylated by its kinase". J. Biol. Chem. 277 (47): 45480–92. doi: 10.1074/jbc.M206201200 . PMID 12223483.
↑ Furusawa M, Ohnishi T, Taira T, Iguchi-Ariga SM, Ariga H (Sep 2001). "AMY-1, a c-Myc-binding protein, is localized in the mitochondria of sperm by association with S-AKAP84, an anchor protein of cAMP-dependent protein kinase". J. Biol. Chem. 276 (39): 36647–51. doi: 10.1074/jbc.M103885200 . PMID 11483602.
1 2 Carlson CR, Ruppelt A, Taskén K (Mar 2003). "A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system". J. Mol. Biol. 327 (3): 609–18. doi:10.1016/S0022-2836(03)00093-7. PMID 12634056.
1 2 Herberg FW, Maleszka A, Eide T, Vossebein L, Tasken K (April 2000). "Analysis of A-kinase anchoring protein (AKAP) interaction with protein kinase A (PKA) regulatory subunits: PKA isoform specificity in AKAP binding". J. Mol. Biol. 298 (2): 329–39. doi:10.1006/jmbi.2000.3662. PMID 10764601.
↑ Kapiloff MS, Schillace RV, Westphal AM, Scott JD (Aug 1999). "mAKAP: an A-kinase anchoring protein targeted to the nuclear membrane of differentiated myocytes". J. Cell Sci. 112 (16): 2725–36. doi:10.1242/jcs.112.16.2725. PMID 10413680.

External links

Human AKAP1 genome location and AKAP1 gene details page in the UCSC Genome Browser .

Lester LB, Scott JD (1997). "Anchoring and scaffold proteins for kinases and phosphatases". Recent Prog. Horm. Res. 52: 409–29, discussion 429–30. PMID 9238861.
Michel JJ, Scott JD (2002). "AKAP mediated signal transduction". Annu. Rev. Pharmacol. Toxicol. 42: 235–57. doi:10.1146/annurev.pharmtox.42.083101.135801. PMID 11807172.
Huang LJ, Durick K, Weiner JA, et al. (1997). "Identification of a novel protein kinase A anchoring protein that binds both type I and type II regulatory subunits". J. Biol. Chem. 272 (12): 8057–64. doi: 10.1074/jbc.272.12.8057 . PMID 9065479.
Huang LJ, Wang L, Ma Y, et al. (1999). "NH2-Terminal Targeting Motifs Direct Dual Specificity A-Kinase–anchoring Protein 1 (D-AKAP1) to Either Mitochondria or Endoplasmic Reticulum". J. Cell Biol. 145 (5): 951–9. doi:10.1083/jcb.145.5.951. PMC 2133123 . PMID 10352013.
Herberg FW, Maleszka A, Eide T, et al. (2000). "Analysis of A-kinase anchoring protein (AKAP) interaction with protein kinase A (PKA) regulatory subunits: PKA isoform specificity in AKAP binding". J. Mol. Biol. 298 (2): 329–39. doi:10.1006/jmbi.2000.3662. PMID 10764601.
Steen RL, Martins SB, Taskén K, Collas P (2000). "Recruitment of Protein Phosphatase 1 to the Nuclear Envelope by a-Kinase Anchoring Protein Akap149 Is a Prerequisite for Nuclear Lamina Assembly". J. Cell Biol. 150 (6): 1251–62. doi:10.1083/jcb.150.6.1251. PMC 2150688 . PMID 10995432.
Furusawa M, Ohnishi T, Taira T, et al. (2001). "AMY-1, a c-Myc-binding protein, is localized in the mitochondria of sperm by association with S-AKAP84, an anchor protein of cAMP-dependent protein kinase". J. Biol. Chem. 276 (39): 36647–51. doi: 10.1074/jbc.M103885200 . PMID 11483602.
Razani B, Lisanti MP (2001). "Two distinct caveolin-1 domains mediate the functional interaction of caveolin-1 with protein kinase A". Am. J. Physiol., Cell Physiol. 281 (4): C1241–50. doi:10.1152/ajpcell.2001.281.4.C1241. PMID 11546661. S2CID 34190425.
Yukitake H, Furusawa M, Taira T, et al. (2003). "AAT-1, a novel testis-specific AMY-1-binding protein, forms a quaternary complex with AMY-1, A-kinase anchor protein 84, and a regulatory subunit of cAMP-dependent protein kinase and is phosphorylated by its kinase". J. Biol. Chem. 277 (47): 45480–92. doi: 10.1074/jbc.M206201200 . PMID 12223483.
Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H (2003). "AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex". J. Biol. Chem. 277 (52): 50885–92. doi: 10.1074/jbc.M206387200 . PMID 12414807.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Carlson CR, Ruppelt A, Taskén K (2003). "A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system". J. Mol. Biol. 327 (3): 609–18. doi:10.1016/S0022-2836(03)00093-7. PMID 12634056.
Steen RL, Beullens M, Landsverk HB, et al. (2004). "AKAP149 is a novel PP1 specifier required to maintain nuclear envelope integrity in G1 phase". J. Cell Sci. 116 (Pt 11): 2237–46. doi: 10.1242/jcs.00432 . PMID 12697839.
Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752 . PMID 14759258.
Cardone L, Carlucci A, Affaitati A, et al. (2004). "Mitochondrial AKAP121 Binds and Targets Protein Tyrosine Phosphatase D1, a Novel Positive Regulator of src Signaling". Mol. Cell. Biol. 24 (11): 4613–26. doi:10.1128/MCB.24.11.4613-4626.2004. PMC 416429 . PMID 15143158.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000121057 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018428 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8769136-5] Trendelenburg G, Hummel M, Riecken EO, Hanski C (Sep 1996). "Molecular characterization of AKAP149, a novel A kinase anchor protein with a KH domain". Biochem Biophys Res Commun. 225 (1): 313–9. doi:10.1006/bbrc.1996.1172. PMID 8769136.

[pmid7499250-6] Lin RY, Moss SB, Rubin CS (Jan 1996). "Characterization of S-AKAP84, a novel developmentally regulated A kinase anchor protein of male germ cells". J Biol Chem. 270 (46): 27804–11. doi: 10.1074/jbc.270.46.27804 . PMID 7499250.

[entrez-7] 1 2 "Entrez Gene: AKAP1 A kinase (PRKA) anchor protein 1".

[pmid12223483-8] 1 2 Yukitake H, Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H (Nov 2002). "AAT-1, a novel testis-specific AMY-1-binding protein, forms a quaternary complex with AMY-1, A-kinase anchor protein 84, and a regulatory subunit of cAMP-dependent protein kinase and is phosphorylated by its kinase". J. Biol. Chem. 277 (47): 45480–92. doi: 10.1074/jbc.M206201200 . PMID 12223483.

[pmid11483602-9] Furusawa M, Ohnishi T, Taira T, Iguchi-Ariga SM, Ariga H (Sep 2001). "AMY-1, a c-Myc-binding protein, is localized in the mitochondria of sperm by association with S-AKAP84, an anchor protein of cAMP-dependent protein kinase". J. Biol. Chem. 276 (39): 36647–51. doi: 10.1074/jbc.M103885200 . PMID 11483602.

[pmid12634056-10] 1 2 Carlson CR, Ruppelt A, Taskén K (Mar 2003). "A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system". J. Mol. Biol. 327 (3): 609–18. doi:10.1016/S0022-2836(03)00093-7. PMID 12634056.

[pmid10764601-11] 1 2 Herberg FW, Maleszka A, Eide T, Vossebein L, Tasken K (April 2000). "Analysis of A-kinase anchoring protein (AKAP) interaction with protein kinase A (PKA) regulatory subunits: PKA isoform specificity in AKAP binding". J. Mol. Biol. 298 (2): 329–39. doi:10.1006/jmbi.2000.3662. PMID 10764601.

[pmid10413680-12] Kapiloff MS, Schillace RV, Westphal AM, Scott JD (Aug 1999). "mAKAP: an A-kinase anchoring protein targeted to the nuclear membrane of differentiated myocytes". J. Cell Sci. 112 (16): 2725–36. doi:10.1242/jcs.112.16.2725. PMID 10413680.

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