MYCBP

Last updated
MYCBP
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MYCBP , AMY-1, MYC binding protein
External IDs OMIM: 606535; MGI: 1891750; HomoloGene: 49312; GeneCards: MYCBP; OMA:MYCBP - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012333

NM_019660

RefSeq (protein)

NP_036465

NP_062634

Location (UCSC) Chr 1: 38.86 – 38.87 Mb Chr 4: 123.8 – 123.81 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

C-Myc-binding protein is a protein that in humans is encoded by the MYCBP gene. [5] [6]

Contents

Function

The MYCBP gene encodes a protein that binds to the N-terminal region of MYC (MIM 190080) and stimulates the activation of E box-dependent transcription by MYC.[supplied by OMIM] [6]

Interactions

MYCBP has been shown to interact with AKAP1, [7] [8] C3orf15 [7] and Myc. [5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000214114 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028647 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 Taira T, Maëda J, Onishi T, Kitaura H, Yoshida S, Kato H, Ikeda M, Tamai K, Iguchi-Ariga SM, Ariga H (Aug 1998). "AMY-1, a novel C-MYC binding protein that stimulates transcription activity of C-MYC". Genes to Cells. 3 (8): 549–65. doi: 10.1046/j.1365-2443.1998.00206.x . PMID   9797456.
  6. 1 2 "Entrez Gene: MYCBP c-myc binding protein".
  7. 1 2 Yukitake H, Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H (Nov 2002). "AAT-1, a novel testis-specific AMY-1-binding protein, forms a quaternary complex with AMY-1, A-kinase anchor protein 84, and a regulatory subunit of cAMP-dependent protein kinase and is phosphorylated by its kinase". The Journal of Biological Chemistry. 277 (47): 45480–92. doi: 10.1074/jbc.M206201200 . PMID   12223483.
  8. Furusawa M, Ohnishi T, Taira T, Iguchi-Ariga SM, Ariga H (Sep 2001). "AMY-1, a c-Myc-binding protein, is localized in the mitochondria of sperm by association with S-AKAP84, an anchor protein of cAMP-dependent protein kinase". The Journal of Biological Chemistry. 276 (39): 36647–51. doi: 10.1074/jbc.M103885200 . PMID   11483602.

Further reading