MYCBP

MYCBP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2YY0
Identifiers
Aliases	MYCBP , AMY-1, MYC binding protein
External IDs	OMIM: 606535 MGI: 1891750 HomoloGene: 49312 GeneCards: MYCBP
Gene location (Human)
Chr.	Chromosome 1 (human)
End	38,873,368 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	123,806,062 bp
RNA expression pattern
	Top expressed in
	monocyte; ; rectum; ; right uterine tube; ; body of pancreas; ; islet of Langerhans; ; right adrenal gland; ; left adrenal gland; ; body of stomach; ; minor salivary gland; ; oocyte;
	Top expressed in
	secondary oocyte; ; olfactory epithelium; ; seminiferous tubule; ; yolk sac; ; morula; ; conjunctival fornix; ; primitive streak; ; ureter; ; medullary collecting duct; ; spermatid;
	More reference expression data
	n/a
Gene ontology
Molecular function	transcription coactivator activity ; protein binding ;
Cellular component	cytoplasm ; nucleus ; mitochondrion ;
Biological process	regulation of transcription, DNA-templated ; transcription, DNA-templated ; spermatogenesis ; positive regulation of nucleic acid-templated transcription ;
	Sources:Amigo / QuickGO
Orthologs
	26292
	56309
	ENSG00000214114
	ENSMUSG00000028647
	Q99417
	Q9EQS3
	NM_012333
	NM_019660
	NP_036465
	NP_062634
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 14, 2023

C-Myc-binding protein is a protein that in humans is encoded by the MYCBP gene.^[5]^[6]

Function

The MYCBP gene encodes a protein that binds to the N-terminal region of MYC (MIM 190080) and stimulates the activation of E box-dependent transcription by MYC.[supplied by OMIM]^[6]

Interactions

MYCBP has been shown to interact with AKAP1,^[7]^[8] C3orf15 ^[7] and Myc.^[5]

Related Research Articles

Myc is a family of regulator genes and proto-oncogenes that code for transcription factors. The Myc family consists of three related human genes: c-myc (MYC), l-myc (MYCL), and n-myc (MYCN). c-myc was the first gene to be discovered in this family, due to homology with the viral gene v-myc.

Ras homolog gene family, member B, also known as RHOB, is a protein which in humans is encoded by the RHOB gene.

Protein deglycase DJ-1, also known as Parkinson disease protein 7, is a protein which in humans is encoded by the PARK7 gene.

cAMP-dependent protein kinase type II-alpha regulatory subunit is an enzyme that in humans is encoded by the PRKAR2A gene.

Proto-oncogene serine/threonine-protein kinase Pim-1 is an enzyme that in humans is encoded by the PIM1 gene.

General transcription factor II-I is a protein that in humans is encoded by the GTF2I gene.

E3 SUMO-protein ligase PIAS2 is an enzyme that in humans is encoded by the PIAS2 gene.

A-kinase anchor protein 13 is a protein that in humans, is encoded by the AKAP13 gene. This protein is also called AKAP-Lbc because it encodes the lymphocyte blast crisis (Lbc) oncogene, and ARHGEF13/RhoGEF13 because it contains a guanine nucleotide exchange factor (GEF) domain for the RhoA small GTP-binding protein.

Alpha-amylase 1 is an enzyme that in humans is encoded by the AMY1A gene. This gene is found in many organisms.

A-kinase anchor protein 5 is a protein that in humans is encoded by the AKAP5 gene.

A-kinase anchor protein 12, aka AKAP250, is an enzyme that in humans is encoded by the AKAP12 gene.

Nuclear transcription factor Y subunit gamma is a protein that in humans is encoded by the NFYC gene.

A kinase anchor protein 1, mitochondrial is an enzyme that in humans is encoded by the AKAP1 gene.

A-kinase anchor protein 8 is an enzyme that, in humans, is encoded by the AKAP8 gene.

A-kinase anchor protein 3 is an enzyme that in humans is encoded by the AKAP3 gene.

Prefoldin subunit 5 is a protein that in humans is encoded by the PFDN5 gene.

A-kinase anchor protein 4 is a scaffold protein that in humans is encoded by the AKAP4 gene. It involves in the intracellular signalling of protein kinase -A. AKAP4 is called as cancer /testis antigen (CTA), it belongs to a class of tumour linked antigens categories by high expression in germ cells and cancer than normal tissues. AKAP4 is not normally expressed in mRNA and protein level in MM cell line.

cGMP-dependent protein kinase 1, alpha isozyme is an enzyme that in humans is encoded by the PRKG1 gene.

AMY-1-associating protein expressed in testis 1 is a protein that in humans is encoded by the MAATS1 gene.

MYCBP associated protein is a protein that in humans is encoded by the MYCBPAP gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000214114 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028647 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Taira T, Maëda J, Onishi T, Kitaura H, Yoshida S, Kato H, Ikeda M, Tamai K, Iguchi-Ariga SM, Ariga H (Aug 1998). "AMY-1, a novel C-MYC binding protein that stimulates transcription activity of C-MYC". Genes to Cells. 3 (8): 549–65. doi: 10.1046/j.1365-2443.1998.00206.x . PMID 9797456.
1 2 "Entrez Gene: MYCBP c-myc binding protein".
1 2 Yukitake H, Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H (Nov 2002). "AAT-1, a novel testis-specific AMY-1-binding protein, forms a quaternary complex with AMY-1, A-kinase anchor protein 84, and a regulatory subunit of cAMP-dependent protein kinase and is phosphorylated by its kinase". The Journal of Biological Chemistry. 277 (47): 45480–92. doi: 10.1074/jbc.M206201200 . PMID 12223483.
↑ Furusawa M, Ohnishi T, Taira T, Iguchi-Ariga SM, Ariga H (Sep 2001). "AMY-1, a c-Myc-binding protein, is localized in the mitochondria of sperm by association with S-AKAP84, an anchor protein of cAMP-dependent protein kinase". The Journal of Biological Chemistry. 276 (39): 36647–51. doi: 10.1074/jbc.M103885200 . PMID 11483602.

Furusawa M, Ohnishi T, Taira T, Iguchi-Ariga SM, Ariga H (Sep 2001). "AMY-1, a c-Myc-binding protein, is localized in the mitochondria of sperm by association with S-AKAP84, an anchor protein of cAMP-dependent protein kinase". The Journal of Biological Chemistry. 276 (39): 36647–51. doi: 10.1074/jbc.M103885200 . PMID 11483602.
Yukitake H, Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H (Aug 2002). "AMAP-1, a novel testis-specific AMY-1-binding protein, is differentially expressed during the course of spermatogenesis". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1577 (1): 126–32. doi:10.1016/s0167-4781(02)00411-6. PMID 12151104.
Yukitake H, Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H (Nov 2002). "AAT-1, a novel testis-specific AMY-1-binding protein, forms a quaternary complex with AMY-1, A-kinase anchor protein 84, and a regulatory subunit of cAMP-dependent protein kinase and is phosphorylated by its kinase". The Journal of Biological Chemistry. 277 (47): 45480–92. doi: 10.1074/jbc.M206201200 . PMID 12223483.
Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H (Dec 2002). "AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex". The Journal of Biological Chemistry. 277 (52): 50885–92. doi: 10.1074/jbc.M206387200 . PMID 12414807.
Tomsig JL, Snyder SL, Creutz CE (Mar 2003). "Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif". The Journal of Biological Chemistry. 278 (12): 10048–54. doi: 10.1074/jbc.M212632200 . PMID 12522145.
Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Ishizaki R, Shin HW, Iguchi-Ariga SM, Ariga H, Nakayama K (Aug 2006). "AMY-1 (associate of Myc-1) localization to the trans-Golgi network through interacting with BIG2, a guanine-nucleotide exchange factor for ADP-ribosylation factors". Genes to Cells. 11 (8): 949–59. doi: 10.1111/j.1365-2443.2006.00991.x . PMID 16866877. S2CID 36364701.
Sedoris KC, Thomas SD, Miller DM (Jul 2007). "c-myc promoter binding protein regulates the cellular response to an altered glucose concentration". Biochemistry. 46 (29): 8659–68. doi:10.1021/bi7003558. PMID 17595061.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000214114 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028647 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9797456-5] 1 2 Taira T, Maëda J, Onishi T, Kitaura H, Yoshida S, Kato H, Ikeda M, Tamai K, Iguchi-Ariga SM, Ariga H (Aug 1998). "AMY-1, a novel C-MYC binding protein that stimulates transcription activity of C-MYC". Genes to Cells. 3 (8): 549–65. doi: 10.1046/j.1365-2443.1998.00206.x . PMID 9797456.

[entrez-6] 1 2 "Entrez Gene: MYCBP c-myc binding protein".

[pmid12223483-7] 1 2 Yukitake H, Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H (Nov 2002). "AAT-1, a novel testis-specific AMY-1-binding protein, forms a quaternary complex with AMY-1, A-kinase anchor protein 84, and a regulatory subunit of cAMP-dependent protein kinase and is phosphorylated by its kinase". The Journal of Biological Chemistry. 277 (47): 45480–92. doi: 10.1074/jbc.M206201200 . PMID 12223483.

[pmid11483602-8] Furusawa M, Ohnishi T, Taira T, Iguchi-Ariga SM, Ariga H (Sep 2001). "AMY-1, a c-Myc-binding protein, is localized in the mitochondria of sperm by association with S-AKAP84, an anchor protein of cAMP-dependent protein kinase". The Journal of Biological Chemistry. 276 (39): 36647–51. doi: 10.1074/jbc.M103885200 . PMID 11483602.

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MYCBP

Contents

Function

Interactions

Related Research Articles

References

Further reading