PRKAR1B

PRKAR1B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4DIN, 4F9K
Identifiers
Aliases	PRKAR1B , PRKAR1, protein kinase cAMP-dependent type I regulatory subunit beta, MASNS
External IDs	OMIM: 176911 MGI: 97759 HomoloGene: 37665 GeneCards: PRKAR1B
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7p22.3 Start 549,197 bp [1] End 727,650 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5 G2|5 77.74 cM Start 139,003,061 bp [2] End 139,135,756 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 10 cingulate gyrus frontal pole Brodmann area 9 amygdala nucleus accumbens hypothalamus putamen caudate nucleus Brodmann area 46 Top expressed in substantia nigra motor neuron dorsal tegmental nucleus ventromedial nucleus dorsomedial hypothalamic nucleus prefrontal cortex subiculum pontine nuclei ventral tegmental area lateral hypothalamus More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding protein kinase A catalytic subunit binding cAMP binding cAMP-dependent protein kinase regulator activity cAMP-dependent protein kinase inhibitor activity protein binding 3',5'-cyclic-GMP phosphodiesterase activity Cellular component cytosol membrane plasma membrane ciliary base cAMP-dependent protein kinase complex synapse Schaffer collateral - CA1 synapse hippocampal mossy fiber to CA3 synapse glutamatergic synapse Biological process regulation of protein phosphorylation activation of protein kinase A activity cellular response to glucagon stimulus blood coagulation negative regulation of cAMP-dependent protein kinase activity protein phosphorylation renal water homeostasis learning or memory modulation of chemical synaptic transmission regulation of synaptic vesicle cycle cGMP-mediated signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5575 19085 Ensembl ENSG00000188191 ENSMUSG00000025855 UniProt P31321 P12849 RefSeq (mRNA) NM_001164758 NM_001164759 NM_001164760 NM_001164761 NM_001164762 NM_002735 NM_001253890 NM_008923 NM_001359097 NM_001359098 NM_001359099 NM_001359100 NM_001359101 RefSeq (protein) NP_001158230 NP_001158231 NP_001158232 NP_001158233 NP_001158234 NP_002726 NP_001240819 NP_032949 NP_001346026 NP_001346027 NP_001346028 NP_001346029 NP_001346030 Location (UCSC) Chr 7: 0.55 – 0.73 Mb Chr 5: 139 – 139.14 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

cAMP-dependent protein kinase type I-beta regulatory subunit is an enzyme that in humans is encoded by the PRKAR1B gene. ^{[5] [6] [7]}

Clinical significance

Mutations in PRKAR1B cause neurodegenerative disorder. ^[8]

Interactions

PRKAR1B has been shown to interact with AKAP1 ^[9] and PRKAR1A. ^{[9] [10]}

References

1. GRCh38: Ensembl release 89: ENSG00000188191 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025855 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Solberg R, Sistonen P, Träskelin AL, Bérubé D, Simard J, Krajci P, Jahnsen T, de la Chapelle A (Dec 1992). "Mapping of the regulatory subunits RI beta and RII beta of cAMP-dependent protein kinase genes on human chromosome 7". Genomics. 14 (1): 63–9. doi:10.1016/S0888-7543(05)80284-8. PMID   1358799.
6. Scambler P, Oyen O, Wainwright B, Farrall M, Law HY, Estivill X, Sandberg M, Williamson R, Jahnsen T (Dec 1987). "Exclusion of catalytic and regulatory subunits of cAMP-dependent protein kinase as candidate genes for the defect causing cystic fibrosis". Am J Hum Genet. 41 (5): 925–32. PMC   1684338 . PMID   3479018.
7. "Entrez Gene: PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta".
8. Wong TH, Chiu WZ, Breedveld GJ, Li KW, Verkerk AJ, Hondius D, Hukema RK, Seelaar H, Frick P, Severijnen LA, Lammers GJ, Lebbink JH, van Duinen SG, Kamphorst W, Rozemuller AJ, Bakker EB, Neumann M, Willemsen R, Bonifati V, Smit AB, van Swieten J (2014). "PRKAR1B mutation associated with a new neurodegenerative disorder with unique pathology". Brain. 137 (Pt 5): 1361–73. doi: 10.1093/brain/awu067 . PMID   24722252.
9. Carlson CR, Ruppelt A, Taskén K (Mar 2003). "A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system". J. Mol. Biol. 327 (3): 609–18. doi:10.1016/S0022-2836(03)00093-7. PMID   12634056.
10. Taskén K, Skålhegg BS, Solberg R, Andersson KB, Taylor SS, Lea T, Blomhoff HK, Jahnsen T, Hansson V (Oct 1993). "Novel isozymes of cAMP-dependent protein kinase exist in human cells due to formation of RI alpha-RI beta heterodimeric complexes". J. Biol. Chem. 268 (28): 21276–83. doi: 10.1016/S0021-9258(19)36921-2 . PMID   8407966.

Further reading

• Harrich D, McMillan N, Munoz L, Apolloni A, Meredith L (2007). "Will diverse Tat interactions lead to novel antiretroviral drug targets?". Current Drug Targets. 7 (12): 1595–606. doi:10.2174/138945006779025338. PMID   17168834.
• Solberg R, Taskén K, Keiserud A, Jahnsen T (1991). "Molecular cloning, cDNA structure and tissue-specific expression of the human regulatory subunit RI beta of cAMP-dependent protein kinases". Biochem. Biophys. Res. Commun. 176 (1): 166–72. doi:10.1016/0006-291X(91)90904-L. PMID   1708242.
• Hofmann B, Nishanian P, Baldwin RL, Insixiengmay P, Nel A, Fahey JL (1991). "HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism". J. Immunol. 145 (11): 3699–705. doi: 10.4049/jimmunol.145.11.3699 . PMID   1978848.
• Hofmann B, Nishanian P, Nguyen T, Insixiengmay P, Fahey JL (1993). "Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes". Proc. Natl. Acad. Sci. U.S.A. 90 (14): 6676–80. Bibcode:1993PNAS...90.6676H. doi: 10.1073/pnas.90.14.6676 . PMC   46995 . PMID   7688126.
• Solberg R, Taskén K, Wen W, Coghlan VM, Meinkoth JL, Scott JD, Jahnsen T, Taylor SS (1994). "Human regulatory subunit RI beta of cAMP-dependent protein kinases: expression, holoenzyme formation and microinjection into living cells". Exp. Cell Res. 214 (2): 595–605. doi:10.1006/excr.1994.1297. PMID   7925653.
• Hofmann B, Nishanian P, Fan J, Nguyen T, Fahey JL (1994). "HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro". AIDS. 8 (7): 1016–7. doi:10.1097/00002030-199407000-00025. PMID   7946090.
• Taskén K, Skålhegg BS, Solberg R, Andersson KB, Taylor SS, Lea T, Blomhoff HK, Jahnsen T, Hansson V (1993). "Novel isozymes of cAMP-dependent protein kinase exist in human cells due to formation of RI alpha-RI beta heterodimeric complexes". J. Biol. Chem. 268 (28): 21276–83. doi: 10.1016/S0021-9258(19)36921-2 . PMID   8407966.
• Swingler S, Gallay P, Camaur D, Song J, Abo A, Trono D (1997). "The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix". J. Virol. 71 (6): 4372–7. doi:10.1128/JVI.71.6.4372-4377.1997. PMC   191654 . PMID   9151826.
• Chen P, Mayne M, Power C, Nath A (1997). "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases". J. Biol. Chem. 272 (36): 22385–8. doi: 10.1074/jbc.272.36.22385 . PMID   9278385.
• Zidovetzki R, Wang JL, Chen P, Jeyaseelan R, Hofman F (1998). "Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways". AIDS Res. Hum. Retroviruses. 14 (10): 825–33. doi:10.1089/aid.1998.14.825. PMID   9671211.
• Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease". Neuroimmunomodulation. 5 (3–4): 184–92. doi:10.1159/000026336. PMID   9730685. S2CID   19529677.
• Laxminarayana D, Khan IU, Mishra N, Olorenshaw I, Taskén K, Kammer GM (1999). "Diminished levels of protein kinase A RI alpha and RI beta transcripts and proteins in systemic lupus erythematosus T lymphocytes". J. Immunol. 162 (9): 5639–48. doi:10.4049/jimmunol.162.9.5639. PMID   10228048. S2CID   84115936.
• Adachi M, Lewis EJ (2002). "The paired-like homeodomain protein, Arix, mediates protein kinase A-stimulated dopamine beta-hydroxylase gene transcription through its phosphorylation status". J. Biol. Chem. 277 (25): 22915–24. doi: 10.1074/jbc.M201695200 . PMID   11943777.
• Oliver CJ, Terry-Lorenzo RT, Elliott E, Bloomer WA, Li S, Brautigan DL, Colbran RJ, Shenolikar S (2002). "Targeting Protein Phosphatase 1 (PP1) to the Actin Cytoskeleton: the Neurabin I/PP1 Complex Regulates Cell Morphology". Mol. Cell. Biol. 22 (13): 4690–701. doi:10.1128/MCB.22.13.4690-4701.2002. PMC   133892 . PMID   12052877.
• Nguyen DT, Rovira II, Finkel T (2002). "Regulation of the Werner helicase through a direct interaction with a subunit of protein kinase A". FEBS Lett. 521 (1–3): 170–4. Bibcode:2002FEBSL.521..170N. doi:10.1016/S0014-5793(02)02868-5. PMID   12067711. S2CID   38098581.
• Mucignat-Caretta C, Caretta A (2003). "Localization of Triton-insoluble cAMP-dependent kinase type RIbeta in rat and mouse brain". J. Neurocytol. 30 (11): 885–94. doi:10.1023/A:1020613132648. PMID   12373096. S2CID   30876154.
• Carlson CR, Ruppelt A, Taskén K (2003). "A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system". J. Mol. Biol. 327 (3): 609–18. doi:10.1016/S0022-2836(03)00093-7. PMID   12634056.

External links

• Overview of all the structural information available in the PDB for UniProt : P31321 (Human cAMP-dependent protein kinase type I-beta regulatory subunit) at the PDBe-KB .