AKAP11

AKAP11
Identifiers
Aliases	AKAP11 , AKAP-11, AKAP220, PPP1R44, PRKA11, A-kinase anchoring protein 11
External IDs	OMIM: 604696 MGI: 2684060 HomoloGene: 8279 GeneCards: AKAP11
Gene location (Human)
Chr.	Chromosome 13 (human)
End	42,323,261 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	78,536,808 bp
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• protein phosphatase 1 binding ; • protein kinase A binding ; • GO:0001948 protein binding ;
Cellular component	• cytoplasm ; • peroxisome ; • cytoskeleton ; • microtubule organizing center ; • nucleolus ; • cytosol ; • cell membrane ;
Biological process	• GO:0007243 intracellular signal transduction ; • regulation of protein kinase A signaling ; • protein localization ;
	Sources:Amigo / QuickGO
Orthologs
	11215
	219181
	ENSG00000023516
	ENSMUSG00000022016
	Q9UKA4
	n/a
	NM_016248 ; NM_144490
	NM_001164503 ; NM_001346784
	NP_057332
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 19, 2021

A-kinase anchor protein 11 is an enzyme that in humans is encoded by the AKAP11 gene.^[5]^[6]^[7]

Function

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed at high levels throughout spermatogenesis and in mature sperm. It binds the RI and RII subunits of PKA in testis. It may serve a function in cell cycle control of both somatic cells and germ cells in addition to its putative role in spermatogenesis and sperm function.^[7]

Interactions

AKAP11 has been shown to interact with:

GSK3B,^[8]
PPP1CA,^[8]^[9]
PRKAR2A,^[6]^[8]^[10]
PRKAR2B.^[11]
VAPB.^[12] Binding is via a FFAT motif in the N-terminal portion of AKAP11, similar to that found in AKAP3. ^[13]

Related Research Articles

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Axin-1 is a protein that in humans is encoded by the AXIN1 gene.

Serine/threonine-protein phosphatase PP1-alpha catalytic subunit is an enzyme that in humans is encoded by the PPP1CA gene.

Mitogen-activated protein kinase 7 also known as MAP kinase 7 is an enzyme that in humans is encoded by the MAPK7 gene.

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform is an enzyme that in humans is encoded by the PPP2R5C gene.

cAMP-dependent protein kinase type I-alpha regulatory subunit is an enzyme that in humans is encoded by the PRKAR1A gene.

cAMP-dependent protein kinase type II-alpha regulatory subunit is an enzyme that in humans is encoded by the PRKAR2A gene.

Segment polarity protein dishevelled homolog DVL-1 is a protein that in humans is encoded by the DVL1 gene.

A-kinase anchor protein 5 is a protein that in humans is encoded by the AKAP5 gene.

Serine/threonine-protein kinase Sgk3 is an enzyme that in humans is encoded by the SGK3 gene.

A-kinase anchor protein 9 is a protein that in humans is encoded by the AKAP9 gene. AKAP9 is also known as Centrosome- and Golgi-localized protein kinase N-associated protein (CG-NAP) or AKAP350 or AKAP450

A-kinase anchor protein 12, aka AKAP250, is an enzyme that in humans is encoded by the AKAP12 gene.

cAMP-dependent protein kinase type I-beta regulatory subunit is an enzyme that in humans is encoded by the PRKAR1B gene.

A kinase anchor protein 1, mitochondrial is an enzyme that in humans is encoded by the AKAP1 gene.

A-kinase anchor protein 8 is an enzyme that, in humans, is encoded by the AKAP8 gene.

A-kinase anchor protein 3 is an enzyme that in humans is encoded by the AKAP3 gene.

Dual specificity protein phosphatase 10 is an enzyme that in humans is encoded by the DUSP10 gene.

A-kinase anchor protein 6 is an enzyme that in humans is encoded by the AKAP6 gene.

Dual specificity protein phosphatase 16 is an enzyme that in humans is encoded by the DUSP16 gene.

Tyrosine-protein phosphatase non-receptor type 21 is an enzyme that in humans is encoded by the PTPN21 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000023516 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022016 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (December 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi: 10.1093/dnares/5.3.169 . PMID 9734811.
1 2 Lester LB, Coghlan VM, Nauert B, Scott JD (June 1996). "Cloning and characterization of a novel A-kinase anchoring protein. AKAP 220, association with testicular peroxisomes" (PDF). J. Biol. Chem. 271 (16): 9460–5. doi: 10.1074/jbc.271.16.9460 . PMID 8621616.
1 2 "Entrez Gene: AKAP11 A kinase (PRKA) anchor protein 11".
1 2 3 Tanji C, Yamamoto H, Yorioka N, Kohno N, Kikuchi K, Kikuchi A (October 2002). "A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta". J. Biol. Chem. 277 (40): 36955–61. doi: 10.1074/jbc.M206210200 . PMID 12147701.
↑ Schillace RV, Scott JD (March 1999). "Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220". Curr. Biol. 9 (6): 321–4. doi: 10.1016/S0960-9822(99)80141-9 . PMID 10209101.
↑ Alto NM, Soderling SH, Hoshi N, Langeberg LK, Fayos R, Jennings PA, Scott JD (April 2003). "Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4445–50. doi: 10.1073/pnas.0330734100 . PMC 153575 . PMID 12672969.
↑ Reinton N, Collas P, Haugen TB, Skâlhegg BS, Hansson V, Jahnsen T, Taskén K (July 2000). "Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis". Dev. Biol. 223 (1): 194–204. doi: 10.1006/dbio.2000.9725 . PMID 10864471.
↑ Huttlin EL, Ting L, Bruckner RJ, Gebreab F, Gygi MP, Szpyt J, et al. (2015). "The BioPlex Network: A Systematic Exploration of the Human Interactome". Cell. 162 (2): 425–40. doi:10.1016/j.cell.2015.06.043. PMC 4617211 . PMID 26186194.
↑ Mikitova V, Levine TP (2012). "Analysis of the key elements of FFAT-like motifs identifies new proteins that potentially bind VAP on the ER, including two AKAPs and FAPP2". PLOS ONE. 7 (1): e30455. doi: 10.1371/journal.pone.0030455 . PMC 3261905 . PMID 22276202.

External links

Human AKAP11 genome location and AKAP11 gene details page in the UCSC Genome Browser .

Lester LB, Scott JD (1997). "Anchoring and scaffold proteins for kinases and phosphatases". Recent Prog. Horm. Res. 52: 409–29, discussion 429–30. PMID 9238861.
Michel JJ, Scott JD (2002). "AKAP mediated signal transduction". Annu. Rev. Pharmacol. Toxicol. 42: 235–57. doi:10.1146/annurev.pharmtox.42.083101.135801. PMID 11807172.
Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi: 10.1093/dnares/9.3.99 . PMID 12168954.
Schillace RV, Scott JD (1999). "Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220". Curr. Biol. 9 (6): 321–4. doi: 10.1016/S0960-9822(99)80141-9 . PMID 10209101.
Reinton N, Collas P, Haugen TB, Skâlhegg BS, Hansson V, Jahnsen T, Taskén K (2000). "Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis". Dev. Biol. 223 (1): 194–204. doi: 10.1006/dbio.2000.9725 . PMID 10864471.
Schillace RV, Voltz JW, Sim AT, Shenolikar S, Scott JD (2001). "Multiple interactions within the AKAP220 signaling complex contribute to protein phosphatase 1 regulation". J. Biol. Chem. 276 (15): 12128–34. doi: 10.1074/jbc.M010398200 . PMID 11152471.
Schillace RV, Andrews SF, Liberty GA, Davey MP, Carr DW (2002). "Identification and characterization of myeloid translocation gene 16b as a novel a kinase anchoring protein in T lymphocytes". J. Immunol. 168 (4): 1590–9. doi: 10.4049/jimmunol.168.4.1590 . PMID 11823486.
Tanji C, Yamamoto H, Yorioka N, Kohno N, Kikuchi K, Kikuchi A (2002). "A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta". J. Biol. Chem. 277 (40): 36955–61. doi: 10.1074/jbc.M206210200 . PMID 12147701.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000023516 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022016 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9734811-5] Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (December 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi: 10.1093/dnares/5.3.169 . PMID 9734811.

[pmid8621616-6] 1 2 Lester LB, Coghlan VM, Nauert B, Scott JD (June 1996). "Cloning and characterization of a novel A-kinase anchoring protein. AKAP 220, association with testicular peroxisomes" (PDF). J. Biol. Chem. 271 (16): 9460–5. doi: 10.1074/jbc.271.16.9460 . PMID 8621616.

[entrez-7] 1 2 "Entrez Gene: AKAP11 A kinase (PRKA) anchor protein 11".

[pmid12147701-8] 1 2 3 Tanji C, Yamamoto H, Yorioka N, Kohno N, Kikuchi K, Kikuchi A (October 2002). "A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta". J. Biol. Chem. 277 (40): 36955–61. doi: 10.1074/jbc.M206210200 . PMID 12147701.

[pmid10209101-9] Schillace RV, Scott JD (March 1999). "Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220". Curr. Biol. 9 (6): 321–4. doi: 10.1016/S0960-9822(99)80141-9 . PMID 10209101.

[pmid12672969-10] Alto NM, Soderling SH, Hoshi N, Langeberg LK, Fayos R, Jennings PA, Scott JD (April 2003). "Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4445–50. doi: 10.1073/pnas.0330734100 . PMC 153575 . PMID 12672969.

[pmid10864471-11] Reinton N, Collas P, Haugen TB, Skâlhegg BS, Hansson V, Jahnsen T, Taskén K (July 2000). "Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis". Dev. Biol. 223 (1): 194–204. doi: 10.1006/dbio.2000.9725 . PMID 10864471.

[pmid26186194-12] Huttlin EL, Ting L, Bruckner RJ, Gebreab F, Gygi MP, Szpyt J, et al. (2015). "The BioPlex Network: A Systematic Exploration of the Human Interactome". Cell. 162 (2): 425–40. doi:10.1016/j.cell.2015.06.043. PMC 4617211 . PMID 26186194.

[pmid22276202-13] Mikitova V, Levine TP (2012). "Analysis of the key elements of FFAT-like motifs identifies new proteins that potentially bind VAP on the ER, including two AKAPs and FAPP2". PLOS ONE. 7 (1): e30455. doi: 10.1371/journal.pone.0030455 . PMC 3261905 . PMID 22276202.

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