ALS2CR2

STRADB
Identifiers
Aliases	STRADB , STE20-related kinase adaptor beta, CALS-21, ILPIP, ILPIPA, PAPK, PRO1038, ALS2CR2, STE20 related adaptor beta
External IDs	OMIM: 607333 MGI: 2144047 HomoloGene: 10237 GeneCards: STRADB
Gene location (Human)
Chr.	Chromosome 2 (human)
End	201,480,846 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	58,995,715 bp
Gene ontology
Molecular function	• protein kinase activity ; • nucleotide binding ; • GO:0001948 protein binding ; • ATP binding ; • protein serine/threonine kinase activity ;
Cellular component	• cytoplasm ; • cell nucleus ; • cytosol ; • aggresome ;
Biological process	• protein phosphorylation ; • cell cycle ; • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ; • activation of protein kinase activity ; • cell cycle arrest ; • cell morphogenesis ; • protein export from nucleus ; • regulation of mitotic cell cycle ; • stress-activated protein kinase signaling cascade ; • regulation of apoptotic process ; • MAPK cascade ; • signal transduction by protein phosphorylation ; • neuron projection morphogenesis ;
	Sources:Amigo / QuickGO
Orthologs
	55437
	227154
	ENSG00000082146
	ENSMUSG00000026027
	Q9C0K7
	Q8K4T3
	NM_001206864 ; NM_018571
	NM_172656 ; NM_173155
	NP_001193793 ; NP_061041
	NP_766244
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 18, 2020

STE20-related kinase adapter protein beta is an enzyme that in humans is encoded by the STRADB gene.^[5]^[6]^[7]

This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene.^[7]

Interactions

ALS2CR2 has been shown to interact with XIAP.^[8]

Related Research Articles

X-linked inhibitor of apoptosis protein (XIAP), also known as inhibitor of apoptosis protein 3 (IAP3) and baculoviral IAP repeat-containing protein 4 (BIRC4), is a protein that stops apoptotic cell death. In humans, this protein (XIAP) is produced by a gene named XIAP gene located on the X chromosome.

Mitogen-activated protein kinase 14, also called p38-α, is an enzyme that in humans is encoded by the MAPK14 gene.

Mitogen-activated protein kinase 8 is a ubiquitous enzyme that in humans is encoded by the MAPK8 gene.

RAC-beta serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT2 gene.

Dual specificity protein phosphatase 1 is an enzyme that in humans is encoded by the DUSP1 gene.

C-jun-amino-terminal kinase-interacting protein 1 is an enzyme that in humans is encoded by the MAPK8IP1 gene.

Serine/threonine-protein kinase 4 is an enzyme that in humans is encoded by the STK4 gene.

Serine/threonine kinase 11 (STK11) also known as liver kinase B1 (LKB1) or renal carcinoma antigen NY-REN-19 is a protein kinase that in humans is encoded by the STK11 gene.

Mitogen-activated protein kinase kinase kinase 14 also known as NF-kappa-B-inducing kinase (NIK) is an enzyme that in humans is encoded by the MAP3K14 gene.

Ribosomal protein S6 kinase alpha-5 is an enzyme that in humans is encoded by the RPS6KA5 gene. This kinase, together with RPS6KA4, are thought to mediate the phosphorylation of histone H3, linked to the expression of immediate early genes.

Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 is an enzyme that in humans is encoded by the MAP3K7IP2 gene.

Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 is an enzyme that in humans is encoded by the MAP3K7IP1 gene.

Mitogen-activated protein kinase kinase kinase 10 is an enzyme that in humans is encoded by the MAP3K10 gene.

Mitogen-activated protein kinase kinase kinase 2 is an enzyme that in humans is encoded by the MAP3K2 gene.

Mitogen-activated protein kinase 12 is an enzyme that in humans is encoded by the MAP3K12 gene.

Calcium-binding protein 39 is a protein that in humans is encoded by the CAB39 gene.

Dual specificity protein phosphatase 16 is an enzyme that in humans is encoded by the DUSP16 gene.

BR serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the BRSK2 gene.

Protein kinase LYK5, also known as LYK5 or STRADα, is a human protein and also denotes the gene encoding it.

BR serine/threonine kinase 1 is an enzyme that in humans is encoded by the BRSK1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000082146 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026027 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hadano S, Yanagisawa Y, Skaug J, Fichter K, Nasir J, Martindale D, Koop BF, Scherer SW, Nicholson DW, Rouleau GA, Ikeda J, Hayden MR (January 2001). "Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2". Genomics. 71 (2): 200–13. doi:10.1006/geno.2000.6392. PMID 11161814.
↑ Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Mäkelä TP, Alessi DR, Hardie DG (Jul 2004). "Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade". Journal of Biology. 2 (4): 28. doi:10.1186/1475-4924-2-28. PMC 333410 . PMID 14511394.
1 2 "Entrez Gene: ALS2CR2 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2".
↑ Sanna MG, da Silva Correia J, Luo Y, Chuang B, Paulson LM, Nguyen B, Deveraux QL, Ulevitch RJ (August 2002). "ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis". The Journal of Biological Chemistry. 277 (34): 30454–62. doi: 10.1074/jbc.M203312200 . PMID 12048196.

External links

Human STRADB genome location and STRADB gene details page in the UCSC Genome Browser .

Alessi DR, Sakamoto K, Bayascas JR (2007). "LKB1-dependent signaling pathways". Annual Review of Biochemistry. 75: 137–63. doi:10.1146/annurev.biochem.75.103004.142702. PMID 16756488.
Boudeau J, Miranda-Saavedra D, Barton GJ, Alessi DR (September 2006). "Emerging roles of pseudokinases". Trends in Cell Biology. 16 (9): 443–52. doi:10.1016/j.tcb.2006.07.003. PMID 16879967.
Sanna MG, da Silva Correia J, Luo Y, Chuang B, Paulson LM, Nguyen B, Deveraux QL, Ulevitch RJ (August 2002). "ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis". The Journal of Biological Chemistry. 277 (34): 30454–62. doi: 10.1074/jbc.M203312200 . PMID 12048196.
Nishigaki K, Thompson D, Yugawa T, Rulli K, Hanson C, Cmarik J, Gutkind JS, Teramoto H, Ruscetti S (April 2003). "Identification and characterization of a novel Ste20/germinal center kinase-related kinase, polyploidy-associated protein kinase". The Journal of Biological Chemistry. 278 (15): 13520–30. doi: 10.1074/jbc.M208601200 . PMID 12574163.
Boudeau J, Baas AF, Deak M, Morrice NA, Kieloch A, Schutkowski M, Prescott AR, Clevers HC, Alessi DR (October 2003). "MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm". The EMBO Journal. 22 (19): 5102–14. doi:10.1093/emboj/cdg490. PMC 204473 . PMID 14517248.
Brajenovic M, Joberty G, Küster B, Bouwmeester T, Drewes G (March 2004). "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network". The Journal of Biological Chemistry. 279 (13): 12804–11. doi: 10.1074/jbc.M312171200 . PMID 14676191.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000082146 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026027 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11161814-5] Hadano S, Yanagisawa Y, Skaug J, Fichter K, Nasir J, Martindale D, Koop BF, Scherer SW, Nicholson DW, Rouleau GA, Ikeda J, Hayden MR (January 2001). "Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2". Genomics. 71 (2): 200–13. doi:10.1006/geno.2000.6392. PMID 11161814.

[pmid14511394-6] Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Mäkelä TP, Alessi DR, Hardie DG (Jul 2004). "Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade". Journal of Biology. 2 (4): 28. doi:10.1186/1475-4924-2-28. PMC 333410 . PMID 14511394.

[entrez-7] 1 2 "Entrez Gene: ALS2CR2 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2".

[pmid12048196-8] Sanna MG, da Silva Correia J, Luo Y, Chuang B, Paulson LM, Nguyen B, Deveraux QL, Ulevitch RJ (August 2002). "ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis". The Journal of Biological Chemistry. 277 (34): 30454–62. doi: 10.1074/jbc.M203312200 . PMID 12048196.

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ALS2CR2

Contents

Interactions

Related Research Articles

References

External links

Further reading