Anaphase-promoting complex subunit 11 is an enzyme that in humans is encoded by the ANAPC11 gene. [5] [6]
Anaphase-promoting complex subunit 11 is an enzyme that in humans is encoded by the ANAPC11 gene. [5] [6]
ANAPC11 has been shown to interact with ANAPC2 [7] [8] and CDC27. [5] [9]
Anaphase-promoting complex is an E3 ubiquitin ligase that marks target cell cycle proteins for degradation by the 26S proteasome. The APC/C is a large complex of 11–13 subunit proteins, including a cullin (Apc2) and RING (Apc11) subunit much like SCF. Other parts of the APC/C have unknown functions but are highly conserved.
Cullin 1, also known as CUL1, is a human protein and gene from cullin family. This protein plays an important role in protein degradation and protein ubiquitination.
Cell division cycle protein 27 homolog is a protein that in humans is encoded by the CDC27 gene.
Cullin-5 is a protein that in humans is encoded by the CUL5 gene.
Cullin-4B is a protein that in humans is encoded by the CUL4B gene which is located on the X chromosome. CUL4B has high sequence similarity with CUL4A, with which it shares certain E3 ubiquitin ligase functions. CUL4B is largely expressed in the nucleus and regulates several key functions including: cell cycle progression, chromatin remodeling and neurological and placental development in mice. In humans, CUL4B has been implicated in X-linked intellectual disability and is frequently mutated in pancreatic adenocarcinomas and a small percentage of various lung cancers. Viruses such as HIV can also co-opt CUL4B-based complexes to promote viral pathogenesis. CUL4B complexes containing Cereblon are also targeted by the teratogenic drug thalidomide.
COP9 signalosome complex subunit 4 is a protein that in humans is encoded by the COPS4 gene.
RING-box protein 2 is a protein that in humans is encoded by the RNF7 gene.
COP9 signalosome complex subunit 8 is a protein that in humans is encoded by the COPS8 gene.
Fizzy-related protein homolog, also known as hCDH1, is a protein that in humans is encoded by the FZR1 gene.
Cell division cycle protein 16 homolog is a protein that in humans is encoded by the CDC16 gene.
Cell division cycle 23 homolog , also known as CDC23, is a protein that, in humans, is encoded by the CDC23 gene.
Anaphase-promoting complex subunit 1 is an enzyme that in humans is encoded by the ANAPC1 gene.
Anaphase-promoting complex subunit 2 is an enzyme that in humans is encoded by the ANAPC2 gene.
Ubiquitin-conjugating enzyme E2 C is a protein that in humans is encoded by the UBE2C gene.
COP9 signalosome complex subunit 7a is a protein that in humans is encoded by the COPS7A gene.
Anaphase-promoting complex subunit 5 is an enzyme that in humans is encoded by the ANAPC5 gene.
Cullin-7 is a RING-E3 ligase protein that in humans is encoded by the CUL7 gene.
Anaphase-promoting complex subunit 7 is an enzyme that in humans is encoded by the ANAPC7 gene. Multiple transcript variants encoding different isoforms have been found for this gene.
Anaphase-promoting complex subunit 10 is an enzyme that in humans is encoded by the ANAPC10 gene.
Anaphase-promoting complex subunit 4 is an enzyme that in humans is encoded by the ANAPC4 gene.