ANAPC2

ANAPC2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4UI9, 4YII, 5A31, 5G05, 5G04
Identifiers
Aliases	ANAPC2 , APC2, anaphase promoting complex subunit 2
External IDs	OMIM: 606946 MGI: 2139135 HomoloGene: 8359 GeneCards: ANAPC2
Gene location (Human)
Chr.	Chromosome 9 (human)
End	137,188,560 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	25,175,927 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; tibial nerve; ; skin of abdomen; ; minor salivary gland; ; body of pancreas; ; body of stomach; ; left uterine tube; ; right lobe of thyroid gland; ; gastric mucosa; ; left lobe of thyroid gland;
	Top expressed in
	internal carotid artery; ; external carotid artery; ; dermis; ; calvaria; ; utricle; ; neural tube; ; abdominal wall; ; ganglionic eminence; ; molar; ; maxillary prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ubiquitin protein ligase activity ; ubiquitin protein ligase binding ; protein binding ;
Cellular component	cytosol ; nucleoplasm ; anaphase-promoting complex ; nucleus ;
Biological process	cell differentiation ; ubiquitin-dependent protein catabolic process ; nervous system development ; positive regulation of synaptic plasticity ; protein K11-linked ubiquitination ; cell division ; positive regulation of synapse maturation ; positive regulation of dendrite morphogenesis ; protein ubiquitination ; cell cycle ; anaphase-promoting complex-dependent catabolic process ; positive regulation of axon extension ; regulation of mitotic cell cycle phase transition ;
	Sources:Amigo / QuickGO
Orthologs
	29882
	99152
	ENSG00000176248
	ENSMUSG00000026965
	Q9UJX6
	Q8BZQ7
	NM_013366
	NM_175300
	NP_037498
	NP_780509
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 14, 2022

Anaphase-promoting complex subunit 2 is an enzyme that in humans is encoded by the ANAPC2 gene.^[5]^[6]

A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation.^[6]

Interactions

ANAPC2 has been shown to interact with ANAPC1 ^[7]^[8] and ANAPC11.^[5]^[9]

Related Research Articles

Anaphase-promoting complex is an E3 ubiquitin ligase that marks target cell cycle proteins for degradation by the 26S proteasome. The APC/C is a large complex of 11–13 subunit proteins, including a cullin (Apc2) and RING (Apc11) subunit much like SCF. Other parts of the APC/C have unknown functions but are highly conserved.

The cell division cycle protein 20 homolog is an essential regulator of cell division that is encoded by the CDC20 gene in humans. To the best of current knowledge its most important function is to activate the anaphase promoting complex (APC/C), a large 11-13 subunit complex that initiates chromatid separation and entrance into anaphase. The APC/C^Cdc20 protein complex has two main downstream targets. Firstly, it targets securin for destruction, enabling the eventual destruction of cohesin and thus sister chromatid separation. It also targets S and M-phase (S/M) cyclins for destruction, which inactivates S/M cyclin-dependent kinases (Cdks) and allows the cell to exit from mitosis. A closely related protein, Cdc20homologue-1 (Cdh1) plays a complementary role in the cell cycle.

Cell division control protein 6 homolog is a protein that in humans is encoded by the CDC6 gene.

Cell division cycle protein 27 homolog is a protein that in humans is encoded by the CDC27 gene.

F-box only protein 5 is a protein that in humans is encoded by the FBXO5 gene.

Fizzy-related protein homolog, also known as hCDH1, is a protein that in humans is encoded by the FZR1 gene.

Cell division cycle protein 16 homolog is a protein that in humans is encoded by the CDC16 gene.

Cell division cycle 23 homolog , also known as CDC23, is a protein that, in humans, is encoded by the CDC23 gene.

Anaphase-promoting complex subunit 1 is an enzyme that in humans is encoded by the ANAPC1 gene.

Ubiquitin-conjugating enzyme E2 C is a protein that in humans is encoded by the UBE2C gene.

Cytoskeleton-associated protein 2 is a protein that in humans is encoded by the CKAP2 gene.

Anaphase-promoting complex subunit 5 is an enzyme that in humans is encoded by the ANAPC5 gene.

Cullin-7 is a RING-E3 ligase protein that in humans is encoded by the CUL7 gene.

Anaphase-promoting complex subunit 7 is an enzyme that in humans is encoded by the ANAPC7 gene. Multiple transcript variants encoding different isoforms have been found for this gene.

Anaphase-promoting complex subunit 10 is an enzyme that in humans is encoded by the ANAPC10 gene.

Anaphase-promoting complex subunit 4 is an enzyme that in humans is encoded by the ANAPC4 gene.

Sister chromatid cohesion protein PDS5 homolog A is a protein that in humans is encoded by the PDS5A gene.

Anaphase-promoting complex subunit 11 is an enzyme that in humans is encoded by the ANAPC11 gene.

Cullins are a family of hydrophobic scaffold proteins which provide support for ubiquitin ligases (E3). All eukaryotes appear to have cullins. They combine with RING proteins to form Cullin-RING ubiquitin ligases (CRLs) that are highly diverse and play a role in myriad cellular processes, most notably protein degradation by ubiquitination.

<span class="mw-page-title-main">APC/C activator protein CDH1</span> Fungal protein found in Saccharomyces cerevisiae S288c

Cdh1 is one of the substrate adaptor protein of the anaphase-promoting complex (APC) in the budding yeast Saccharomyces cerevisiae. Functioning as an activator of the APC/C, Cdh1 regulates the activity and substrate specificity of this ubiquitin E3-ligase. The human homolog is encoded by the FZR1 gene, which is not to be confused with the CDH1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000176248 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026965 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Tang Z, Li B, Bharadwaj R, Zhu H, Ozkan E, Hakala K, Deisenhofer J, Yu H (December 2001). "APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex". Mol Biol Cell. 12 (12): 3839–51. doi:10.1091/mbc.12.12.3839. PMC 60759 . PMID 11739784.
1 2 "Entrez Gene: ANAPC2 anaphase promoting complex subunit 2".
↑ Vodermaier, Hartmut C; Gieffers, Christian; Maurer-Stroh, Sebastian; Eisenhaber, Frank; Peters, Jan-Michael (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459–68. doi: 10.1016/S0960-9822(03)00581-5 . ISSN 0960-9822. PMID 12956947. S2CID 5942532.
↑ Sumara, I; Vorlaufer E; Gieffers C; Peters B H; Peters J M (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". J. Cell Biol. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. ISSN 0021-9525. PMC 2169443 . PMID 11076961.
↑ Ohta, T; Michel J J; Schottelius A J; Xiong Y (April 1999). "ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity". Mol. Cell. 3 (4): 535–41. doi:10.1016/S1097-2765(00)80482-7. ISSN 1097-2765. PMID 10230407. S2CID 19371828.

External links

Human ANAPC2 genome location and ANAPC2 gene details page in the UCSC Genome Browser .
Human APC2 genome location and APC2 gene details page in the UCSC Genome Browser .

Yu H, Peters JM, King RW, et al. (1998). "Identification of a cullin homology region in a subunit of the anaphase-promoting complex". Science. 279 (5354): 1219–22. Bibcode:1998Sci...279.1219Y. doi:10.1126/science.279.5354.1219. PMID 9469815.
Grossberger R, Gieffers C, Zachariae W, et al. (1999). "Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex". J. Biol. Chem. 274 (20): 14500–7. doi: 10.1074/jbc.274.20.14500 . PMID 10318877.
Gieffers C, Peters BH, Kramer ER, et al. (1999). "Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11317–22. Bibcode:1999PNAS...9611317G. doi: 10.1073/pnas.96.20.11317 . PMC 18031 . PMID 10500174.
Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi: 10.1093/dnares/7.1.65 . PMID 10718198.
Gmachl M, Gieffers C, Podtelejnikov AV, et al. (2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 8973–8. Bibcode:2000PNAS...97.8973G. doi: 10.1073/pnas.97.16.8973 . PMC 16806 . PMID 10922056.
Jarrett CR, Blancato J, Cao T, et al. (2001). "Human APC2 localization and allelic imbalance". Cancer Res. 61 (21): 7978–84. PMID 11691822.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Vodermaier HC, Gieffers C, Maurer-Stroh S, et al. (2004). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459–68. doi: 10.1016/S0960-9822(03)00581-5 . PMID 12956947. S2CID 5942532.
Capron A, Serralbo O, Fülöp K, et al. (2004). "The Arabidopsis anaphase-promoting complex or cyclosome: molecular and genetic characterization of the APC2 subunit". Plant Cell. 15 (10): 2370–82. doi:10.1105/tpc.013847. PMC 197302 . PMID 14508008.
Kraft C, Herzog F, Gieffers C, et al. (2004). "Mitotic regulation of the human anaphase-promoting complex by phosphorylation". EMBO J. 22 (24): 6598–609. doi:10.1093/emboj/cdg627. PMC 291822 . PMID 14657031.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081 . PMID 15164053.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148 . PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Dube P, Herzog F, Gieffers C, et al. (2006). "Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C". Mol. Cell. 20 (6): 867–79. doi: 10.1016/j.molcel.2005.11.008 . PMID 16364912.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000176248 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026965 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11739784-5] 1 2 Tang Z, Li B, Bharadwaj R, Zhu H, Ozkan E, Hakala K, Deisenhofer J, Yu H (December 2001). "APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex". Mol Biol Cell. 12 (12): 3839–51. doi:10.1091/mbc.12.12.3839. PMC 60759 . PMID 11739784.

[entrez-6] 1 2 "Entrez Gene: ANAPC2 anaphase promoting complex subunit 2".

[pmid12956947-7] Vodermaier, Hartmut C; Gieffers, Christian; Maurer-Stroh, Sebastian; Eisenhaber, Frank; Peters, Jan-Michael (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459–68. doi: 10.1016/S0960-9822(03)00581-5 . ISSN 0960-9822. PMID 12956947. S2CID 5942532.

[pmid11076961-8] Sumara, I; Vorlaufer E; Gieffers C; Peters B H; Peters J M (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". J. Cell Biol. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. ISSN 0021-9525. PMC 2169443 . PMID 11076961.

[pmid10230407-9] Ohta, T; Michel J J; Schottelius A J; Xiong Y (April 1999). "ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity". Mol. Cell. 3 (4): 535–41. doi:10.1016/S1097-2765(00)80482-7. ISSN 1097-2765. PMID 10230407. S2CID 19371828.

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ANAPC2

Contents

Interactions

Related Research Articles

References

External links

Further reading