ANAPC2

ANAPC2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UI9, 4YII, 5A31, 5G05, 5G04
Identifiers
Aliases	ANAPC2 , APC2, anaphase promoting complex subunit 2
External IDs	OMIM: 606946; MGI: 2139135; HomoloGene: 8359; GeneCards: ANAPC2; OMA:ANAPC2 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9q34.3 Start 137,174,784 bp [1] End 137,188,560 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 A3 Start 25,162,490 bp [2] End 25,175,927 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube right hemisphere of cerebellum left testis right testis granulocyte left ovary right ovary skin of leg tibial nerve skin of abdomen Top expressed in internal carotid artery external carotid artery ventricular zone dermis calvaria vestibular membrane of cochlear duct utricle neural tube efferent ductule abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquitin protein ligase activity ubiquitin protein ligase binding protein binding Cellular component cytosol nucleoplasm anaphase-promoting complex nucleus Biological process cell differentiation ubiquitin-dependent protein catabolic process nervous system development positive regulation of synaptic plasticity protein K11-linked ubiquitination cell division positive regulation of synapse maturation positive regulation of dendrite morphogenesis protein ubiquitination cell cycle anaphase-promoting complex-dependent catabolic process positive regulation of axon extension regulation of mitotic cell cycle phase transition Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29882 99152 Ensembl ENSG00000176248 ENSMUSG00000026965 UniProt Q9UJX6 Q8BZQ7 RefSeq (mRNA) NM_013366 NM_175300 RefSeq (protein) NP_037498 NP_780509 Location (UCSC) Chr 9: 137.17 – 137.19 Mb Chr 2: 25.16 – 25.18 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Anaphase-promoting complex subunit 2 is an enzyme that in humans is encoded by the ANAPC2 gene. ^{[5] [6]}

A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. ^[6]

Interactions

ANAPC2 has been shown to interact with ANAPC1 ^{[7] [8]} and ANAPC11. ^{[5] [9]}

References

1. GRCh38: Ensembl release 89: ENSG00000176248 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026965 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tang Z, Li B, Bharadwaj R, Zhu H, Ozkan E, Hakala K, Deisenhofer J, Yu H (December 2001). "APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex". Mol Biol Cell. 12 (12): 3839–51. doi:10.1091/mbc.12.12.3839. PMC   60759 . PMID   11739784.
6. "Entrez Gene: ANAPC2 anaphase promoting complex subunit 2".
7. Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459–68. Bibcode:2003CBio...13.1459V. doi: 10.1016/S0960-9822(03)00581-5 . ISSN   0960-9822. PMID   12956947. S2CID   5942532.
8. Sumara I, Vorlaufer E, Gieffers C, Peters B H, Peters J M (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". J. Cell Biol. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. ISSN   0021-9525. PMC   2169443 . PMID   11076961.
9. Ohta T, Michel J J, Schottelius A J, Xiong Y (April 1999). "ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity". Mol. Cell. 3 (4): 535–41. doi: 10.1016/S1097-2765(00)80482-7 . ISSN   1097-2765. PMID   10230407. S2CID   19371828.

External links

• Human ANAPC2 genome location and ANAPC2 gene details page in the UCSC Genome Browser .
• Human APC2 genome location and APC2 gene details page in the UCSC Genome Browser .

Further reading

• Yu H, Peters JM, King RW, et al. (1998). "Identification of a cullin homology region in a subunit of the anaphase-promoting complex". Science. 279 (5354): 1219–22. Bibcode:1998Sci...279.1219Y. doi:10.1126/science.279.5354.1219. PMID   9469815.
• Grossberger R, Gieffers C, Zachariae W, et al. (1999). "Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex". J. Biol. Chem. 274 (20): 14500–7. doi: 10.1074/jbc.274.20.14500 . PMID   10318877.
• Gieffers C, Peters BH, Kramer ER, et al. (1999). "Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11317–22. Bibcode:1999PNAS...9611317G. doi: 10.1073/pnas.96.20.11317 . PMC   18031 . PMID   10500174.
• Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi: 10.1093/dnares/7.1.65 . PMID   10718198.
• Gmachl M, Gieffers C, Podtelejnikov AV, et al. (2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 8973–8. Bibcode:2000PNAS...97.8973G. doi: 10.1073/pnas.97.16.8973 . PMC   16806 . PMID   10922056.
• Jarrett CR, Blancato J, Cao T, et al. (2001). "Human APC2 localization and allelic imbalance". Cancer Res. 61 (21): 7978–84. PMID   11691822.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Vodermaier HC, Gieffers C, Maurer-Stroh S, et al. (2004). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459–68. Bibcode:2003CBio...13.1459V. doi: 10.1016/S0960-9822(03)00581-5 . PMID   12956947. S2CID   5942532.
• Capron A, Serralbo O, Fülöp K, et al. (2004). "The Arabidopsis anaphase-promoting complex or cyclosome: molecular and genetic characterization of the APC2 subunit". Plant Cell. 15 (10): 2370–82. doi:10.1105/tpc.013847. PMC   197302 . PMID   14508008.
• Kraft C, Herzog F, Gieffers C, et al. (2004). "Mitotic regulation of the human anaphase-promoting complex by phosphorylation". EMBO J. 22 (24): 6598–609. doi:10.1093/emboj/cdg627. PMC   291822 . PMID   14657031.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC   2734081 . PMID   15164053.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Dube P, Herzog F, Gieffers C, et al. (2006). "Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C". Mol. Cell. 20 (6): 867–79. doi: 10.1016/j.molcel.2005.11.008 . hdl: 11858/00-001M-0000-0010-9405-4 . PMID   16364912.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.