ANAPC1

ANAPC1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4UI9, 5A31, 5G04, 5G05
Identifiers
Aliases	ANAPC1 , APC1, MCPR, TSG24, anaphase promoting complex subunit 1
External IDs	OMIM: 608473 MGI: 103097 HomoloGene: 7414 GeneCards: ANAPC1
Gene location (Human)
Chr.	Chromosome 2 (human)
End	111,884,690 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	128,529,311 bp
RNA expression pattern
	Top expressed in
	kidney; ; lung; ; Achilles tendon; ; stomach; ; middle temporal gyrus; ; heart; ; sural nerve; ; colon;
	More reference expression data
	n/a
Gene ontology
Molecular function	GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity ;
Cellular component	nucleoplasm ; cytosol ; anaphase-promoting complex ; nucleus ;
Biological process	cell cycle ; anaphase-promoting complex-dependent catabolic process ; protein ubiquitination ; protein K11-linked ubiquitination ; cell division ; GO:0051323 metaphase/anaphase transition of mitotic cell cycle ; regulation of mitotic cell cycle phase transition ; ubiquitin-dependent protein catabolic process ;
	Sources:Amigo / QuickGO
Orthologs
	64682
	17222
	ENSG00000153107
	ENSMUSG00000014355
	Q9H1A4
	P53995
	NM_022662
	NM_008569
	NP_073153
	NP_032595
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 28, 2022

Anaphase-promoting complex subunit 1 is an enzyme that in humans is encoded by the ANAPC1 gene.^[5]^[6]

ANAPC1 is one of at least ten subunits of the anaphase-promoting complex (APC), which functions at the metaphase-to-anaphase transition of the cell cycle and is regulated by spindle checkpoint proteins. The APC is an E3 ubiquitin ligase that targets cell cycle regulatory proteins for degradation by the proteasome, thereby allowing progression through the cell cycle (supplied by OMIM).^[6]

Interactions

ANAPC1 has been shown to interact with ANAPC5,^[7]^[8] ANAPC4,^[7]^[8] ANAPC2,^[7]^[8] CDC27 ^[7]^[8] and ANAPC7.^[7]^[8]

Related Research Articles

The cell division cycle protein 20 homolog is an essential regulator of cell division that is encoded by the CDC20 gene in humans. To the best of current knowledge its most important function is to activate the anaphase promoting complex (APC/C), a large 11-13 subunit complex that initiates chromatid separation and entrance into anaphase. The APC/C^Cdc20 protein complex has two main downstream targets. Firstly, it targets securin for destruction, enabling the eventual destruction of cohesin and thus sister chromatid separation. It also targets S and M-phase (S/M) cyclins for destruction, which inactivates S/M cyclin-dependent kinases (Cdks) and allows the cell to exit from mitosis. A closely related protein, Cdc20homologue-1 (Cdh1) plays a complementary role in the cell cycle.

Mitotic spindle assembly checkpoint protein MAD2A is a protein that in humans is encoded by the MAD2L1 gene.

Cell division cycle protein 27 homolog is a protein that in humans is encoded by the CDC27 gene.

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 is a protein that in humans is encoded by the GNB2 gene.

RNA polymerase II subunit A C-terminal domain phosphatase is an enzyme that in humans is encoded by the CTDP1 gene.

Coatomer subunit alpha is a protein that in humans is encoded by the COPA gene.

Regulator of G-protein signaling 19 is a protein that in humans is encoded by the RGS19 gene.

Fizzy-related protein homolog, also known as hCDH1, is a protein that in humans is encoded by the FZR1 gene.

Cell division cycle protein 16 homolog is a protein that in humans is encoded by the CDC16 gene.

Cell division cycle 23 homolog , also known as CDC23, is a protein that, in humans, is encoded by the CDC23 gene.

DNA polymerase delta subunit 2 is an enzyme that in humans is encoded by the POLD2 gene. It is a component of the DNA polymerase delta complex.

Anaphase-promoting complex subunit 2 is an enzyme that in humans is encoded by the ANAPC2 gene.

Cytoskeleton-associated protein 2 is a protein that in humans is encoded by the CKAP2 gene.

Anaphase-promoting complex subunit 5 is an enzyme that in humans is encoded by the ANAPC5 gene.

Anaphase-promoting complex subunit 7 is an enzyme that in humans is encoded by the ANAPC7 gene. Multiple transcript variants encoding different isoforms have been found for this gene.

40S ribosomal protein S15 is a protein that in humans is encoded by the RPS15 gene.

Anaphase-promoting complex subunit 10 is an enzyme that in humans is encoded by the ANAPC10 gene.

Anaphase-promoting complex subunit 4 is an enzyme that in humans is encoded by the ANAPC4 gene.

Sister chromatid cohesion protein PDS5 homolog A is a protein that in humans is encoded by the PDS5A gene.

Anaphase-promoting complex subunit 11 is an enzyme that in humans is encoded by the ANAPC11 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000153107 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000014355 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Jorgensen PM, Graslund S, Betz R, Stahl S, Larsson C, Hoog C (February 2001). "Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex". Gene. 262 (1–2): 51–9. doi:10.1016/S0378-1119(00)00511-4. PMID 11179667.
1 2 "Entrez Gene: ANAPC1 anaphase promoting complex subunit 1".
1 2 3 4 5 Vodermaier, Hartmut C; Gieffers, Christian; Maurer-Stroh, Sebastian; Eisenhaber, Frank; Peters, Jan-Michael (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459–68. doi: 10.1016/S0960-9822(03)00581-5 . ISSN 0960-9822. PMID 12956947. S2CID 5942532.
1 2 3 4 5 Sumara, I; Vorlaufer E; Gieffers C; Peters B H; Peters J M (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". J. Cell Biol. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. ISSN 0021-9525. PMC 2169443 . PMID 11076961.

External links

Human ANAPC1 genome location and ANAPC1 gene details page in the UCSC Genome Browser .

Grossberger R, Gieffers C, Zachariae W, et al. (1999). "Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex". J. Biol. Chem. 274 (20): 14500–7. doi: 10.1074/jbc.274.20.14500 . PMID 10318877.
Gieffers C, Peters BH, Kramer ER, et al. (1999). "Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11317–22. Bibcode:1999PNAS...9611317G. doi: 10.1073/pnas.96.20.11317 . PMC 18031 . PMID 10500174.
Gmachl M, Gieffers C, Podtelejnikov AV, et al. (2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 8973–8. Bibcode:2000PNAS...97.8973G. doi: 10.1073/pnas.97.16.8973 . PMC 16806 . PMID 10922056.
Zur A, Brandeis M (2001). "Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis". EMBO J. 20 (4): 792–801. doi:10.1093/emboj/20.4.792. PMC 145417 . PMID 11179223.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Vodermaier HC, Gieffers C, Maurer-Stroh S, et al. (2004). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459–68. doi: 10.1016/S0960-9822(03)00581-5 . PMID 12956947. S2CID 5942532.
Kraft C, Herzog F, Gieffers C, et al. (2004). "Mitotic regulation of the human anaphase-promoting complex by phosphorylation". EMBO J. 22 (24): 6598–609. doi:10.1093/emboj/cdg627. PMC 291822 . PMID 14657031.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi: 10.1073/pnas.0507066103 . PMC 1459365 . PMID 16565220.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000153107 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000014355 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11179667-5] Jorgensen PM, Graslund S, Betz R, Stahl S, Larsson C, Hoog C (February 2001). "Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex". Gene. 262 (1–2): 51–9. doi:10.1016/S0378-1119(00)00511-4. PMID 11179667.

[entrez-6] 1 2 "Entrez Gene: ANAPC1 anaphase promoting complex subunit 1".

[pmid12956947-7] 1 2 3 4 5 Vodermaier, Hartmut C; Gieffers, Christian; Maurer-Stroh, Sebastian; Eisenhaber, Frank; Peters, Jan-Michael (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459–68. doi: 10.1016/S0960-9822(03)00581-5 . ISSN 0960-9822. PMID 12956947. S2CID 5942532.

[pmid11076961-8] 1 2 3 4 5 Sumara, I; Vorlaufer E; Gieffers C; Peters B H; Peters J M (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". J. Cell Biol. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. ISSN 0021-9525. PMC 2169443 . PMID 11076961.

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ANAPC1

Contents

Interactions

Related Research Articles

References

External links

Further reading