ANAPC4

ANAPC4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4UI9, 5BPW, 5A31, 5G05, 5G04
Identifiers
Aliases	ANAPC4 , APC4, anaphase promoting complex subunit 4
External IDs	OMIM: 606947 MGI: 1098673 HomoloGene: 40873 GeneCards: ANAPC4
Gene location (Human)
Chr.	Chromosome 4 (human)
End	25,418,498 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	53,025,139 bp
RNA expression pattern
	Top expressed in
	endometrium; ; tendon; ; peritoneum; ; fallopian tube; ; caput epididymis; ; visceral pleura;
	More reference expression data
	n/a
Gene ontology
Molecular function	ubiquitin-protein transferase activity ; protein phosphatase binding ; GO:0001948 protein binding ; GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity ;
Cellular component	anaphase-promoting complex ; cytosol ; nucleus ; nucleoplasm ; nuclear periphery ;
Biological process	anaphase-promoting complex-dependent catabolic process ; regulation of mitotic metaphase/anaphase transition ; cell division ; protein K11-linked ubiquitination ; cell cycle ; protein ubiquitination ; positive regulation of mitotic metaphase/anaphase transition ; regulation of mitotic cell cycle phase transition ; ubiquitin-dependent protein catabolic process ;
	Sources:Amigo / QuickGO
Orthologs
	29945
	52206
	ENSG00000053900
	ENSMUSG00000029176
	Q9UJX5
	Q91W96
	NM_001286756 ; NM_013367
	NM_024213
	NP_001273685 ; NP_037499
	NP_077175
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 06, 2022

Anaphase-promoting complex subunit 4 is an enzyme that in humans is encoded by the ANAPC4 gene.^[5]^[6]

A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The exact function of this gene product is not known.^[6]

Interactions

ANAPC4 has been shown to interact with ANAPC1,^[7]^[8] ANAPC5,^[7] CDC27 ^[7]^[9] and ANAPC7.^[7]

Related Research Articles

Anaphase-promoting complex is an E3 ubiquitin ligase that marks target cell cycle proteins for degradation by the 26S proteasome. The APC/C is a large complex of 11–13 subunit proteins, including a cullin (Apc2) and RING (Apc11) subunit much like SCF. Other parts of the APC/C have unknown functions but are highly conserved.

The cell division cycle protein 20 homolog is an essential regulator of cell division that is encoded by the CDC20 gene in humans. To the best of current knowledge its most important function is to activate the anaphase promoting complex (APC/C), a large 11-13 subunit complex that initiates chromatid separation and entrance into anaphase. The APC/C^Cdc20 protein complex has two main downstream targets. Firstly, it targets securin for destruction, enabling the eventual destruction of cohesin and thus sister chromatid separation. It also targets S and M-phase (S/M) cyclins for destruction, which inactivates S/M cyclin-dependent kinases (Cdks) and allows the cell to exit from mitosis. A closely related protein, Cdc20homologue-1 (Cdh1) plays a complementary role in the cell cycle.

Mitotic spindle assembly checkpoint protein MAD2A is a protein that in humans is encoded by the MAD2L1 gene.

Cell division cycle protein 27 homolog is a protein that in humans is encoded by the CDC27 gene.

RNA polymerase II subunit A C-terminal domain phosphatase is an enzyme that in humans is encoded by the CTDP1 gene.

F-box only protein 5 is a protein that in humans is encoded by the FBXO5 gene.

Fizzy-related protein homolog, also known as hCDH1, is a protein that in humans is encoded by the FZR1 gene.

Cell division cycle protein 16 homolog is a protein that in humans is encoded by the CDC16 gene.

Cell division cycle 23 homolog , also known as CDC23, is a protein that, in humans, is encoded by the CDC23 gene.

DNA polymerase delta subunit 2 is an enzyme that in humans is encoded by the POLD2 gene. It is a component of the DNA polymerase delta complex.

Anaphase-promoting complex subunit 1 is an enzyme that in humans is encoded by the ANAPC1 gene.

Anaphase-promoting complex subunit 2 is an enzyme that in humans is encoded by the ANAPC2 gene.

Cytoskeleton-associated protein 2 is a protein that in humans is encoded by the CKAP2 gene.

Anaphase-promoting complex subunit 5 is an enzyme that in humans is encoded by the ANAPC5 gene.

Anaphase-promoting complex subunit 7 is an enzyme that in humans is encoded by the ANAPC7 gene. Multiple transcript variants encoding different isoforms have been found for this gene.

40S ribosomal protein S15 is a protein that in humans is encoded by the RPS15 gene.

Anaphase-promoting complex subunit 10 is an enzyme that in humans is encoded by the ANAPC10 gene.

Sister chromatid cohesion protein PDS5 homolog A is a protein that in humans is encoded by the PDS5A gene.

Anaphase-promoting complex subunit 11 is an enzyme that in humans is encoded by the ANAPC11 gene.

HAUS augmin-like complex subunit 3 is a protein that in humans is encoded by the HAUS3 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000053900 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029176 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Tekolf WA, Biddison WE, Aster RD, Shaw S (October 1982). "Two subgroups of HLA Bw44 defined by cell-mediated lympholysis that differ in Bw44 expression on platelets and in patterns of genetic linkage disequilibrium". J Immunol. 129 (4): 1474–8. PMID 6180011.
1 2 "Entrez Gene: ANAPC4 anaphase promoting complex subunit 4".
1 2 3 4 Vodermaier, Hartmut C; Gieffers, Christian; Maurer-Stroh, Sebastian; Eisenhaber, Frank; Peters, Jan-Michael (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459–68. doi: 10.1016/S0960-9822(03)00581-5 . ISSN 0960-9822. PMID 12956947. S2CID 5942532.
↑ Sumara, I; Vorlaufer E; Gieffers C; Peters B H; Peters J M (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". J. Cell Biol. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. ISSN 0021-9525. PMC 2169443 . PMID 11076961.
↑ Gmachl, M; Gieffers C; Podtelejnikov A V; Mann M; Peters J M (August 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 8973–8. Bibcode:2000PNAS...97.8973G. doi: 10.1073/pnas.97.16.8973 . ISSN 0027-8424. PMC 16806 . PMID 10922056.

External links

Human ANAPC4 genome location and ANAPC4 gene details page in the UCSC Genome Browser .

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID 8889548.
Yu H, Peters JM, King RW, et al. (1998). "Identification of a cullin homology region in a subunit of the anaphase-promoting complex". Science. 279 (5354): 1219–22. Bibcode:1998Sci...279.1219Y. doi:10.1126/science.279.5354.1219. PMID 9469815.
Grossberger R, Gieffers C, Zachariae W, et al. (1999). "Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex". J. Biol. Chem. 274 (20): 14500–7. doi: 10.1074/jbc.274.20.14500 . PMID 10318877.
Gieffers C, Peters BH, Kramer ER, et al. (1999). "Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11317–22. Bibcode:1999PNAS...9611317G. doi: 10.1073/pnas.96.20.11317 . PMC 18031 . PMID 10500174.
Gmachl M, Gieffers C, Podtelejnikov AV, et al. (2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 8973–8. Bibcode:2000PNAS...97.8973G. doi: 10.1073/pnas.97.16.8973 . PMC 16806 . PMID 10922056.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Vodermaier HC, Gieffers C, Maurer-Stroh S, et al. (2004). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459–68. doi: 10.1016/S0960-9822(03)00581-5 . PMID 12956947. S2CID 5942532.
Kraft C, Herzog F, Gieffers C, et al. (2004). "Mitotic regulation of the human anaphase-promoting complex by phosphorylation". EMBO J. 22 (24): 6598–609. doi:10.1093/emboj/cdg627. PMC 291822 . PMID 14657031.
Johnson JM, Castle J, Garrett-Engele P, et al. (2004). "Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays". Science. 302 (5653): 2141–4. Bibcode:2003Sci...302.2141J. doi:10.1126/science.1090100. PMID 14684825. S2CID 10007258.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000053900 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029176 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid6180011-5] Tekolf WA, Biddison WE, Aster RD, Shaw S (October 1982). "Two subgroups of HLA Bw44 defined by cell-mediated lympholysis that differ in Bw44 expression on platelets and in patterns of genetic linkage disequilibrium". J Immunol. 129 (4): 1474–8. PMID 6180011.

[entrez-6] 1 2 "Entrez Gene: ANAPC4 anaphase promoting complex subunit 4".

[pmid12956947-7] 1 2 3 4 Vodermaier, Hartmut C; Gieffers, Christian; Maurer-Stroh, Sebastian; Eisenhaber, Frank; Peters, Jan-Michael (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459–68. doi: 10.1016/S0960-9822(03)00581-5 . ISSN 0960-9822. PMID 12956947. S2CID 5942532.

[pmid11076961-8] Sumara, I; Vorlaufer E; Gieffers C; Peters B H; Peters J M (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". J. Cell Biol. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. ISSN 0021-9525. PMC 2169443 . PMID 11076961.

[pmid10922056-9] Gmachl, M; Gieffers C; Podtelejnikov A V; Mann M; Peters J M (August 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 8973–8. Bibcode:2000PNAS...97.8973G. doi: 10.1073/pnas.97.16.8973 . ISSN 0027-8424. PMC 16806 . PMID 10922056.

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ANAPC4

Contents

Interactions

Related Research Articles

References

External links

Further reading